|
Last Loaded on Web: Wednesday, August 23, 2000
CANCERLIT® is produced by the International Cancer Research DataBank Branch (ICRDB) of the U.S. National Cancer Institute. The database consists of bibliographic records referencing cancer research publications dating from 1963 to the present. Most records contain abstracts, and all records contain citation information and additional descriptive fields such as document type and language. Beginning with the June 1983 CANCERLIT update, records from the MEDLINE® database dealing with cancer topics have been added to CANCERLIT.
Records added to CANCERLIT since January 1980 are indexed using the U.S. National Library of Medicine (NLM) Medical Subject Heading (MeSH®). The CANCERLIT records with MeSH descriptors are updated annually with the current version of MeSH headings. An online thesaurus is available to aid in locating MeSH descriptors. All records added before June 1983 have abstracts; approximately 75% of the records added since June 1983 have abstracts.
USE THE (L) OPERATORto link descriptors and subheadings: S PROTEIN KINASES(L)MES CELL DIVISION(L)DRUG EFFECTS USE EXPLODE (!)to search narrower descriptors in the MeSH vocabulary: S TUMOR CELLS, CULTURED!USE THE ONLINE THESAURUSto check and select MeSH thesaurus terms: E (DNA DAMAGE)USE MAPto take CAS® Registry Numbers to another file: MAP RN TEMP S1USE LIMITS/HUMAN for human subjects /ENG for English-language articles |
CANCERLIT includes indexing for articles from more than 3,500 journals; approximatley 200 core journals contribute a large percentage of the citations. Selected records are taken from the MEDLINE database beginning in June 1983. In addition, proceedings of meetings, government reports, symposia reports, selected monographs, and theses are also abstracted for inclusion in the database.
Dates Covered: | 1975 to the present |
---|---|
File Size: | Over 1,595,000 records as of August 2000 |
Update Frequency: | Monthly (Approximately 7,000 records per update) |
ACRONYM | CATEGORY NAME |
---|---|
CASREGNO | CAS(R) Registry Numbers-Chemical and Medical Files |
MEDICINE | Medicine |
NURSING | Nursing and Health Administration |
RNMED | CAS(R) Registry Numbers - Medical Files |
CANCERLIT is produced by the U.S. National Cancer Institute (NCI). Questions concerning file content should be directed to:
Telephone: | 301-594-5983 |
---|---|
800 Line: | 888-346-3656 |
Fax: | 301-496-0822 |
Some material in this Database is from copyrighted publications of the respective copyright claimants. Users of the Database are referred to the publication data appearing in the bibliographic citations, as well as to the copyright notices appearing in the original publication, all of which are hereby incorporated by reference. NCI represents that the Database is formulated with a reasonable standard of care. Except for this representation, and as otherwise specifically provided, NCI makes no representations or warranties, express or implied, including any implied warranty of merchantability or fitness for a particular purpose, with respect to the Database. Licensee shall inform all users of this limitation in writing.
A user may electronically archive information in machine-readable form for no more than twelve (12) months. Retention of the input date field is recommended to ensure accurate and timely purging of archived information. User shall be responsible for incorporating current updates into such archived information. Further, redistribution and/or archiving requires the intent not to create a derivative work. Specifically, derivative works which facilitate insurance reimbursement or financially based patient care decisions are expressly not permitted.
DIALOG(R)File 159:CancerLit(R) | |
(c) fmt only 2000 The Dialog Corp. All rts. reserv. | |
AN= | 01603257 20270250 |
/TI | Distinct Chk2 activation pathways are triggered by genistein and |
DNA-damaging agents in human melanoma cells. | |
AU= | Darbon JM; Penary M; Escalas N; Casagrande F; Goubin-Gramatica F; |
Baudouin C; Ducommun B | |
CS= | Laboratoire de Biologie Cellulaire et Moleculaire du Controle de la |
Proliferation Cellulaire, UMR 5088 CNRS, Universite Paul Sabatier, 118 | |
Route de Narbonne, 31062 Toulouse Cedex, France. darbon@cict.fr | |
JN=,PY=,SN=,JC= | J Biol Chem; 275(20):15363-9 2000 ISSN 0021-9258 Journal Code: HIV |
CN= | Contract/Grant No.: CA44579, CA, NCI |
NT= | Comment in Cancer Invest 2000 ;18(5):498-500 |
LA= | Languages: ENGLISH |
DT= | Document Type: JOURNAL ARTICLE |
JA= | Journal Announcement: 200007 |
SF= | Subfile: L; M; X MEDL/20270250 |
/AB | Genistein, a natural isoflavone found in soybeans, exerts a number of |
biological actions suggesting that it may have a role in cancer prevention. | |
We have previously shown that it potently inhibits OCM-1 melanoma cell | |
proliferation by inducing a G(2) cell cycle arrest. Here we show that | |
genistein exerts this effect by impairing the Cdc25C-dependent Tyr-15 | |
dephosphorylation of Cdk1, as the overexpression of this phosphatase allows | |
the cells to escape G(2) arrest and enter an abnormal chromatin | |
condensation stage. Caffeine totally overrides the genistein-induced G(2) | |
arrest, whereas the block caused by etoposide is not bypassed and that | |
caused by adriamycin is only partially abolished. We also report that | |
genistein activates the checkpoint kinase Chk2 as efficiently as the two | |
genotoxic agents and that caffeine may counteract the activation of Chk2 by | |
genistein but not by etoposide. In contrast, caffeine abolishes the | |
accumulation of p53 caused by all the compounds. Wortmannin does not | |
suppress the Chk2 activation in any situation, suggesting that the ataxia | |
telangiectasia-mutated kinase is not involved in this regulation. Finally, | |
unlike etoposide and adriamycin, genistein induces only a weak response in | |
terms of DNA damage in OCM-1 cells. Taken together, these results suggest | |
that the G(2) checkpoints activated by genistein and the two genotoxic | |
agents involve different pathways. | |
/GS | Tags: Human; Support, Non-U.S. Gov't |
/DE | Major Descriptors: Caffeine--Pharmacology--PD; *Cell Cycle-- Drug Effects |
--DE; *Cell Division-- Drug Effects--DE; *Doxorubicin --Pharmacology--PD; | |
*DNA Damage; *Etoposide--Pharmacology--PD; *Genistein--Pharmacology--PD; | |
*Protein Kinases--Metabolism--ME | |
Minor Descriptors: cdc25 Phosphatase--Metabolism--ME; Cell Cycle Proteins | |
--Metabolism--ME; Choroid Neoplasms; Enzyme Activation; G2 Phase; Melanoma; | |
Tumor Cells, Cultured | |
/ID,RN= | CAS Registry No.: 0 (Cdc25C protein); 0 (Cell Cycle Proteins); |
23214-92-8 (Doxorubicin); 33419-42-0 (Etoposide); 446-72-0 (Genistein) | |
; 58-08-2 (Caffeine) | |
/ID,EC= | Enzyme No.: EC 2.7.1.- (Cds1 kinase); EC 2.7.1.37 (Protein Kinases); |
EC 3.1.3.- (cdc25 Phosphatase) |
SEARCH SUFFIX |
DISPLAY CODE |
FIELD NAME |
INDEXING |
SELECT EXAMPLES |
---|---|---|---|---|
None | None | All Basic Index Fields | Word | S GENOTOXIC(W)AGENT? |
/AB | AB | Abstract1 | Word | S MELANOMA(W)CELL?/AB |
/DE | DE | Descriptor2,3 | Word & Phrase |
S PROTEIN(W)KINASES/DE S CHOROID NEOPLASMS/DE |
/GS | GS | Check Tags3 | Word & Phrase |
S SUPPORT(3W)GOV?/GS S SUPPORT, NON-U.S. GOV'T/GS |
/ID | ID | Identifier 4,5,6,7 | Word & Phrase |
S CELL(W)CYCLE(W)PROTEIN?/ID S CDS25C PROTEIN/ID |
/TI | TI | Title | Word | S HUMAN(W)MELANOMA(W)CELL?/TI |
1 Abstracts present for about 75% of the records added since June 1983. Abstracts present for all records added before June 1983.
3 Records added prior to January 1980 do not have MeSH descriptors or check tags.
5 Includes CAS Registry Number, Enzyme Commission Number, Gene Symbol, Enzyme Name, Chemical Name.
6 Beginning in June 1983 for MEDLINE-derived records, and beginning in June 1985 for all other records. Includes gene symbol in 1991-1995 which is searchable using /DE or /ID and displayable either in the DE field or in the ID field.
7 Chemical Names and Enzyme Names are searchable in the Basic Index as /ID; CAS Registry Number and Enzyme Commission Number are searchable in the Additional Indexes as EC= and RN=. A search term will appear in the display in the RN field or the EC field.
SEARCH PREFIX |
DISPLAY CODE |
FIELD NAME |
INDEXING |
SELECT EXAMPLES |
---|---|---|---|---|
None | AN | DIALOG Accession Number | ||
AN= | AN | NLM Accession Number | Phrase | S AN=20270250 |
AU= | AU | Author | Phrase | S AU=DARBON JM |
BN= | BN | International Standard Book Number (ISBN)8 | Phrase | S BN=0-306-45136-0 |
CN= | CN | Contract/Grant Number9 | Phrase | S CN=CA44579 |
CS= | CS | Corporate Source | Word & Phrase |
S CS=(UNIVERSITE(W)PAUL(W)SABATIER) S CS=LABORATOIRE DE BIOLOGIE? |
DC= | None | Descriptor Code10 | Phrase | S DC=G4.335.135. |
DT= | DT | Document Type | Phrase | S DT=JOURNAL ARTICLE |
EC= | EC | Enzyme Commission Number | Phrase | S EC=2.7.1.37 |
JA= | JA | Journal Announcement | Phrase | S JA=200007 |
JC= | JC | Journal Code11 | Phrase | S JC=HIV |
JN= | JN | Journal Name12 | Phrase | S JN=JOURNAL OF BIOLOGICAL CHEMISTRY |
LA= | LA | Language | Phrase | S LA=ENGLISH |
NT= | NT | Note/Comment13 | Word | S NT=(CANCER(W)INVEST?) |
PY= | PY | Publication Year | Phrase | S PY=2000 |
RN= | RN | CAS(R) Registry Number14 | Phrase | S RN=23214-92-8 |
SF= | SF | Subfile | Phrase | S SF=MEDL |
SN= | SN | International Standard Serial Number (ISSN)15 | Phrase | S SN=0021-9258 |
SO= | SO | Source Information16 | Word | S SO=(JOURNAL(2W)CHEMISTRY) |
UD= | None | Update | Phrase | S UD=9999 |
8 Available from 1990 forward.
9 For MEDLINE-derived records beginning in June 1980.
10 Descriptor Code Explodes can also be searched using the descriptor name followed by an exclamation mark (i.e., SELECT CELLS, CULTURED!). Descriptor codes do not display in records.
11 Beginning in June 1980 for journals indexed by NLM.
12 Journal Names are searchable as either the full name or the abbreviated name depending on a record; displayable as the abbreviated name.
13 Beginning in 1989 for MEDLINE-derived records only.
14 Beginning in June 1980 for MEDLINE records and in June 1985 for all other records.
15 Not present in all records.
16 Display includes Journal Name, Volume, Issue, Pagination, and Publication Year. Includes publisher information for monographs/reports.
Sets and terms may be limited by Basic Index suffixes, i.e., /AB, /DE /DE*, DF, /DF*, /ID, /IF, /TI (e.g., S S5/DE), as well as by the features listed below: | ||
SUFFIX | FIELD NAME | EXAMPLES |
---|---|---|
/ABS | Abstract Present | S S3/ABS |
/ENG | English-Language Documents | S S2/ENG |
/HUMAN | Human Subject | S S1/HUMAN |
/MAJ | Major Descriptor | S S5/MAJ |
/NOABS | No Abstract Present | S S4/NOABS |
/NONENG | Non-English Language Documents | S S6/NONENG |
/YYYY | Publication Year | S S7/2000 |
SORTABLE FIELDS | EXAMPLES |
---|---|
AU, CS, JN, PY, TI | SORT S3/ALL/AU SORT S1/ALL/PY/D |
RANK FIELDS | EXAMPLES |
---|---|
All phrase- and numeric-indexed fields in the Additional Indexes can be ranked. Other RANK codes include: DE, ID | RANK AU S3 RANK DE S1 |
MAP FIELDS | EXAMPLES |
---|---|
CS, RN | MAP CS TEMP S1 MAP RN TEMP S2 |
User-defined formats may be specified using the display codes indicated in the Search Options tables. | TYPE S2/AU,TI/1-5 PRINT S1/TI,AB/ALL |
NO. |
DIALOGWEB FORMAT |
RECORD CONTENT |
---|---|---|
1 | -- | DIALOG Accession Number |
2 | -- | Full Record except Abstract |
3 | Medium | Bibliographic Citation |
4 | -- | Full Record with Tagged Fields1 |
5 | -- | Full Record1 |
6 | Free | Title and Publication Year |
7 | Long | Bibliographic Citation and Abstract1 |
8 | Short | Title, Indexing and Publication Year |
9 | Full | Full Record1 |
K | -- | KWIC (Key Word In Context) displays a window of text; may be used alone or with other formats |
FIELD NAME | EXAMPLES | ||
---|---|---|---|
DIALOG Accession Number | TYPE 03869010/5 DISPLAY 03870556/AU,TI PRINT 03825646/9 |
Rates For File: CANCERLIT®[159]
|