Abattoir |
Slaughterhouse |
ACVO |
Assistant Chief Veterinary Officer |
ADROIT |
Adverse Drug Reactions On-Line Information Tracking database |
Adsorbed |
Adsorbed vaccines involve the adhesion of a substance to an organic particle in the solution |
AFRC |
Agriculture and Food Research Council |
AHVG |
Animal Health Veterinary Group |
AMD |
Animal Medicines Division, Animal Health Directorate |
Antibodies |
Protein molecules produced by the body as its primary immune defence |
ATC |
Animal test certificate |
Autoclave |
Apparatus which uses superheated steam under high pressure. Widely used in hospitals and laboratories to sterilise material |
BABs |
Cattle that are verified as having been Born After ruminant feed Ban on 18 July 1988, and that are confirmed to be BSE positive on histopathological, or scrapie-associated fibrils, examination |
BC |
Biologicals Committee, MAFF |
BGA |
German Federal Health Office |
bovine |
Of, relating to or resembling members of the Bovidae group of animals (ie, cattle) |
BP&S |
Biological Products and Standards Department, CVL |
British Isles |
England, Wales, Scotland, Northern Ireland and the Republic of Ireland |
BSA |
Bovine serum albumin |
BSC |
Biologicals Sub-Committee of the Committee on the Safety of Medicines (CSM) (also referred to as CSM/BSC) |
BSE |
Bovine Spongiform Encephalopathy, a slowly progressinve and ultimately fatal neurological disorder of adult cattle. See also TSE |
BSEWG |
BSE Working Group of the CSM, CDSM and CRM |
Buffy coat |
Layer of white cells at the interface between supernatant plasma and the red cell deposit that remains after blood is centrifuged |
BWP |
Biotechnology Working Party of the CPMP |
Casein |
Proteins isolated from milk |
CDSM |
Committee on Dental and Surgical Materials |
CEC |
Commission of the European Communities |
CHS |
Chemical Hazards Section, CSU |
CJD |
Creutzfeldt-Jakob Disease, a human spongiform encephalopathy |
CMO |
Chief Medical Officer, DH |
COLIPA |
European cosmetics trade association |
CPMP |
Committee for Proprietary Medicinal Products, EC/EU |
CRM |
Committee on the Review of Medicines |
CSG |
Chief Scientists Group, MAFF |
CSM |
Committee on Safety of Medicines |
CSU |
Consumer Safety Unit, DTI |
CTC |
Clinical trial certificate |
CTPA |
Cosmetics, Toiletries and Perfumery Association Ltd, UK |
CTX |
Clinical Trial Exemption |
CVL |
Central Veterinary Laboratory, MAFF |
CVMP |
Committee for Veterinary Medicinal Products, EC/EU |
CVO |
Chief Veterinary Officer |
DCMO |
Deputy Chief Medical Officer |
DES |
Department of Education and Science |
DH |
Department of Health (from 1988) |
DNA |
Deoxyribonucleic acid |
DTI |
Department of Trade and Industry |
DTP |
Diphtheria, tetanus and pertussis vaccine |
Dura mater |
The outermost and strongest of the three membranes or meninges which envelop the brain and spinal cord |
Dural implant |
Implant of dura mater into the body as part of a medical device |
EC |
(1) Usually, European Community (or Communities). When the European Union came into existence on 1 November 1993 as a result of the Maastricht Treaty, it incorporated but did not replace the EC. The term EC is still sometimes used in this context. Throughout the volumes of this Report the term EU is more generally used for consistency's sake (even if sometimes chronologically incorrect), except where specific reference is made to the functions conferred by the European Community Treaty or to its legal effect |
|
(2) Sometimes, European Commission (known as the Commission of the European Communities before 1993) |
ECWPC |
EC Working Party on Cosmetics |
EMEA |
European Medicines Evaluation Agency |
encephalopathy |
A degenerative disorder of the brain |
EU |
European Union. See also EC |
excipient |
A basically inert substance added to give an appropriate consistency or form to a drug |
FCS |
foetal calf serum |
HEF M |
Health Aspects of Environment and Food Medical, DH |
HPSS |
Health and Personal Social Services Group, DH |
HSE |
Health and Safety Executive |
HVMBG |
Human and Veterinary Medicines Briefing Group |
IAH |
Institute for Animal Health |
Iatrogenesis |
Any adverse mental or physical condition induced in a patient through the effects of treatment by a physician or surgeon (adjective: iatrogenic). (Taber) |
ic |
intercerebrally, ie, into the brain |
IKS |
Federal Swiss regulatory authority for pharmaceuticals |
ISPA |
The Pathology and Blood Transfusion Services Branch of the Inspectorate of Anatomy, Scientific Services, Pathology |
IYSC |
In Year Service Contract; CVL surveillance work commissioned by CVO |
JCVI |
Joint Committee on Vaccination and Immunisation |
Licensing Authority |
Health and Agriculture Ministers, having responsibility for human and veterinary medicines licensing under the Medicines Act 1968 |
Lipids |
Biological molecules only slightly soluble in water; includes fats and waxes |
MAFF |
Ministry of Agriculture, Fisheries and Food |
MAIL |
Medicines Act Information Leaflet |
MBM |
Meat and bone meal. Animal-derived protein produced by rendering. Used as a protein source in animal feed |
MB1 |
Administrative branch, Medicines Division, DH |
MB1B |
Section of MB1 responsible for the product licence database |
MB1C |
Section in MB1 providing the administrative lead on policy for medicines licensing issues for which the CSM was the appropriate advisory body |
MB3A |
New drugs and biologicals branch, Medicines Division, DH |
MB3B |
Review of medicines and dental and surgical materials branch, Medicines Division, DH |
MB4 |
Adverse reactions and post-marketing surveillance branch, Medicines Division, DH |
MB5 |
Pharmaceutical branch, Medicines Division, DH |
MB5A |
Professional pharmaceutical aspects of Medicines Act, Medicines Division, DH |
MB5B |
Medicines inspectorate, Medicines Division, DH |
MB5C |
British Pharmacopoeia Commission, Medicines Division, DH |
MCA |
Medicines Control Agency |
MDA |
Medical Devices Agency |
MDD |
Medical Devices Directorate |
MED TEP |
Medical Toxicology Environmental Protection; also known as Medical Toxicology and Environmental Health (MED TEH) |
MHD |
Meat Hygiene Divison, MAFF |
MMR |
Measles, mumps and rubella vaccine |
Monoclonal antibodies |
Identical antibodies made in large amount in the laboratory |
MRC |
Medical Research Council |
MRS |
Manufacturers' Registration Scheme |
NHS |
National Health Service |
NIBSC |
National Institute for Biological Standards and Control |
NOAH |
National Office of Animal Health |
NPU |
Neuropathogenesis Unit |
Offal |
Internal organs and entrails of animals |
Ovine |
Of or relating to sheep |
Parenteral inoculation |
Inoculation by any route other than by the mouth or by the bowel |
PD |
Procurement Directorate, DH |
Pericardium tissue |
A double membranous sac which envelops and protects the heart |
PES |
Public Expenditure Survey |
PG |
Policy Group (MAFF) |
PHLS |
Public Health Laboratory Service |
phospholipids |
Lipids containing one or more phosphate groups |
PLR |
Product Licence of Right |
PLUS |
Product Licence User System |
PMO |
Principal Medical Officer |
Porcine |
Of or characteristic of pigs |
protein |
A folded chain of amino acids |
PSTS |
Pharmaceutical Supply and Technology Section |
render |
(rendering process) Processing offal and other parts of discarded animal carcasses to make MBM and tallow |
RMD |
Research Management Division, DH |
RVC |
Royal Veterinary College |
SARS |
Suspected Adverse Reactions Scheme |
SBO |
Specified Bovine Offal |
SCC |
Scientific Committee on Cosmetology |
Scrapie |
A spongiform encephalopathy (SE) endemic in British sheep. Also found in goats. Can be transmitted experimentally to other animals such as mice. The experimental model for work on spongiform encephalopathies |
SEAC |
Spongiform Encephalopathy Advisory Committee |
SEAR |
Safety, Efficacy and Adverse Reactions subcommittee of the CSM |
slow viruses |
An umbrella term for those viruses whose effects on the nervous system take a long time to show after their initial infection of the host |
SMO |
Senior Medical Officer |
Southwood Working Party |
Established in May 1988 to examine the implications of BSE in relation to both animal and human health, and to advise the Government |
SPMO |
Senior Principal Medical Officer |
Sporadic disease |
Occurring in single cases here and there, as distinct from an epidemic |
STD |
Supplies Technology Division, Procurement Directorate, DH |
SVS |
State Veterinary Service |
therapeutic bovine anti-serum |
Serum containing immunoglobulins against specified antigens |
titre |
A measure of concentration of a substance (in this Report, of an infectious agent) in a solution |
topical |
Of drugs or treatments applied locally to the area being treated |
TSE |
Transmissible spongiform encephalopathy. Disease of the neurological system. Spongy degeneration of the brain with progressive dementia. Examples in humans include CJD and kuru. Among animals: scrapie and BSE |
Tuberculin PPD |
Tuberculosis antigen injected into the skin to test for previous infection by tuberculosis bacteria |
Tyrrell Committee |
Consultative Committee on Research, established 27 February 1989 on the recommendation of the Southwood Report and chaired by Dr Tyrrell, to advise MAFF and DH on research into spongiform encephalopathies. Reestablished as SEAC in April 1990 |
vCJD |
New variant CJD |
VMD |
Veterinary Medicines Directorate |
VPC |
Veterinary Products Committee |
WHO |
World Health Organisation |
Zoonosis |
Animal disease which can be transmitted to humans |