Implant Wear in Total Joint Replacement: Clinical and Biologic Issues, Material and Design Considerations


Edited by Timothy M. Wright, PhD and Stuart B. Goodman, MD, PhD


A symposium held in October 2000
Supported by National Institute of Arthritis and Musculoskeletal and Skin Diseases
ISBN number 0-89203-261-8

Copyright©2001 by the American Academy of Orthopaedic Surgeons
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Preface
Contributors
Staff

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Table of Contents
Clinical Issues

Chapter 1 What is the clinical scope of implant wear in the hip and how has it changed since 1995?
Chapter 2 What is the clinical scope of implant wear in the knee and how has it changed since 1995?
Chapter 3 What patient-related factors contribute to implant wear?
Chapter 4 What surgical-related factors contribute to implant wear?
Chapter 5 How should wear-related implant surveillance be carried out and what methods are indicated to diagnose wear-related problems?
Chapter 6 What are the systemic consequences of wear debris clinically?
Chapter 7 What guidelines/algorithms (both operative and nonoperative) are there for the treatment of osteolysis?
Chapter 8 What are the best outcome measures for wear?
Chapter 9 What is the outcome of the treatment of osteolysis?

Biologic Issues

Chapter 10 What are the local and systemic biologic reactions to wear debris?
Chapter 11 What are the mediators (cellular, molecular, etc) of the local and systemic biologic reactions to wear debris?
Chapter 12 Are there host factors that determine/modulate the biologic response to wear particles?
Chapter 13 What specific features of wear particles are most important in determining the adverse biologic reactions?
Chapter 14 What is the role of endotoxin and fluid pressure in osteolysis?
Chapter 15 What experimental approaches (tissue retrieval, in vivo, in vitro, etc) have been used to investigate the biologic effects of particles?
Chapter 16 Are there biologic markers of wear?
Chapter 17 What potential biologic treatments are there for osteolysis?

Material and Design Considerations

Chapter 18 What design and material factors influence wear in total joint replacement?
Chapter 19 What is the role of wear testing and joint simulator studies in discriminating among materials and designs?
Chapter 20 What design factors influence wear behavior in total knee replacement?
Chapter 21 What design factors influence wear behavior at the articulating surfaces in total hip replacement?
Chapter 22 What are the wear mechanisms and what controls them?
Chapter 23 What material properties and manufacturing procedures influence wear mechanisms?
Chapter 24 What modifications can be made to materials to improve wear behavior?
Chapter 25 What evidence is there for using alternative bearing materials?


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Last modified 01/February/2002 by IS