National Cancer Institute
Science Behind the News Understanding Cancer
A list of the genes implicated in cancer.

Gene Mutations and Cancer

Mutations in genes that control normal cell proliferation can lead to cancer. These mutations can be created by DNA-damaging carcinogens such as cigarette by-products and radiation. However, some cancer-causing mutations are simply spontaneous errors that appear in normal DNA molecules when cells duplicate their DNA prior to cell division. The mutations that contribute to the development of cancer affect three general classes of gene: oncogenes, tumor suppressor genes, and DNA repair genes.

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