As a young girl she learned to read and write. She was not only pretty, but also very intelligent. Although these talents made her somewhat overbearing, as a child, she was already betrothed to the Liu family. However, at the age of 18, she already made a vow of chastity to Christ and when she learned of the betrothal, she appealed to her parents' piety and love of God to cancel the marriage. That same year Fr. Matthew Liu told her to enter the girls' school in Guiyang. Only two years later, another persecution began and her father was once again arrested and tortured. The family home was robbed clean of all their belongings and possessions and after her father was released, he could no longer work from his poor health conditions. Thus, Agatha and her mother had to earn a living to support the family. A visit by Fr. Thomas Liu changed her knowledge of the faith and brought her to teach catechism. After the death of her father, her mother decided to live with her son from her previous marriage. Therefore, allowing Agatha to follow her own vocation. She became the directress of Fr. Liu's new girls' school, and formally made the vow of chastity at the age of twenty-five. A year later Msgr. Bai, the new Apostolic Administrator of the Guizhou diocese, made her head of the convent in Guiyang. There, she led an austere life noted for her special care of the poor and the young.

In 1857, when Wang Bing was imprisoned for being a Christian, she was arrested as well. The County magistrate questioned her virginity and asked her why she wanted to live life as a virgin. She response was: "Is it wrong for the authority to set up a Chastity Monument?" At that trial, Wang Bing and Lu Tingmei both spoke up in her favor and ridiculed the magistrate. Stung by fury, he condemned the prisoners to death. They were to be executed the next day. After death, stripped of their clothes, she was discovered to be indeed a virgin and the magistrate admitted that he had made a mistake. Also, it was reported that three bands of light, two red and one white, surrounded the martyrs' bodies and some non-Christians from a distance saw three globes of light in the sky after their execution.

On May 2nd, 1909, Pope Pius X beatified her and Pope John Paul II added her name to the list of the canonized Martyrs on October 1st, 2000.