A Polite Request...
The popularity of the Peter Kenny Generator has led to calls for a Roger Sayle Machine. The dearth of direct quotes, however, may mean it will generate sentences randomly from an approved lexicon. If you have any (documented, please) suggestions for additions, please leave them in the comments. These can be complete sentences or just phrases. Thank you.
Eat More Curry
APN also plays a significant role in angiogenesis. Angiogenesis, the formation of new blood vessels, is essential for tumor growth and the transmission of cancerous cells from the original site to new ones. Past studies have shown that curcumin can arrest angiogenesis, leading researchers to enter the chemopreventitive agent into Phase I clinical trials for cancer chemoprevention by the National Cancer Institute.
Some claim it is also good for the skin; some husbands of those making such claims assert it turns you orangey.
XML User Interface Language
Method for Computing Protein Binding Affinity
The method involves extending configuration space by a discrete variable indicating whether the ligand is bound to the protein and a special Monte Carlo move which allows transitions between the unbound and bound states. Provided that an accurate protein structure is given, that the protein-ligand binding site is known, and that an accurate chemical force field together with a continuum solvation model is used, this method provides a quantitative estimate of the free energy of binding.
Shiny Disk Make Rainbow
Java CML Filter Library
The library makes use of the Chemical Data Object Programming Interface (CDOPI). Using the JCF Library means that the Java program must define a class that implements CDOPI. JCFL uses this subclass to store information taken from a CML file or stores the information in the subclass into a CML file.
Supports JMol animationN, JChemPaint, PDB and MDLMol files.
Peter Kenny in Electronic Form
Various SMILES depicters on the Web, including:
SMi Drug Design Conference
The primary purpose of this interactive workshop is the identification and discussion of the critical issues related to using high-throughput molecular docking (HTMD) as a source for novel lead molecules. Delegates will receive an overview of different algorithms and processes for effectively carrying out HTMD and gain a better understanding of opportunities and limitations, ligand-related issues, target processing, docking schemes and scoring functions, measuring performance and emerging technologies.
It'll be interesting to see who chooses to go to this instead of MUG.
A Robot Scientist
Though they chose genetics to test their idea, Dr King and his colleagues think it could be applied to other fields where vast numbers of small, fiddly experiments need to be done in order to arrive at a result—for example, drug design and certain sorts of advanced chemical synthesis. One question is, if their robot does make an important discovery, will it be eligible to win a Nobel prize?
Funny, most of the scientists I know are such animated people. I can't imagine this one fitting in at all.
Petty Criminals and Tableware
Drugs are good (Good drugs are better). Pat Walters, Vertex Pharmaceuticals
Talking to Chemists: When louder isn't enough. Roger Sayle
We've been looking at proteins in Astex Viewer.
It can be used as an Applet in a web page and as a desktop application. The software should run on most operating systems and in most internet browsers ... The Electron Density page shows reconstructed electron density for protein/ligand complexes from the extended GOLD validation set. This validation set was selected by Astex and the Cambridge Crystallographic Data Centre. The electron density has been generated for the 70 complexes for which structure factors have been deposited at the Protein Data Bank.
Note careful use of the word 'most.' Still, pretty neat.