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The Health Effects Institute

"A Partnership of the U.S. Environmental Protection Agency and Industry"


HEI's website is regularly updated with the latest news and results. Thank you for visiting!

Fall 2004 HEI Update now online!   NEW 
Read about an upcoming review of the current science on the possible health effects of mobile-source related air toxics; a soon-to-be published study of the effects of ultrafine carbon particles on human airways; three new studies of air pollution and health in India; several reports that will be published soon; this year's winners of our new investigator awards, and much more. To download the newsletter, click here (PDF, 870 KB).

HEI issues Fall 2004 Research Agenda – September 2004 
HEI has issued Requests for Applications on Measuring the Health Impacts of Actions to Improve Air Quality (Accountability), the New Investigator Award, and Preliminary Applications on the Health Effects of Air Pollution on HEI's funding page. The RFA booklet is now available for downloading

PM Workshop presentations available – October 2004  
As part of its initiative to implement a systematic approach to a key PM research need looking forward, HEI held a workshop "Research to Investigate the Characteristics and Sources of PM Associated with Toxicity" in August 2004 in Baltimore MD. The Agenda and Presentations from the workshop are now available. Please click here to read about the workshop and access the presentations.  

HEI publishes report on Health Effects of Particles in Rats with Features of Asthma or Bronchitis – September 2004
HEI investigators at Michigan State University and the University of Michigan have just completed this report on their study to evaluate the short-term effects of inhaling concentrated ambient particles derived from the air in an area of Detroit, Michigan on rats with some features of asthma and bronchitis. The study took place in a Detroit neighborhood that has a high incidence of childhood asthma. The investigators assessed two key features of asthma: airway inflammation and hypersecretion of mucus in groups of rats that had been sensitized with the allergen ovalbumin to induce some features of asthma; and in rats pretreated with endotoxin to have some features of mild bronchitis. 
Click here
to download Research Report 120, Effects of Concentrated Ambient Particles on Normal and Hypersecretory Airways in Rats (including the Commentary of the HEI Review Committee), or the HEI Statement (a short synopsis) for each report.

HEI publishes Part III of the National Morbidity, Mortality and Air Pollution Study – June 2004 
Research Report 94, Part III: Concentration–Response Curves and Thresholds for the 20 Largest US Cities, reports on work by Dr Michael J Daniels and others (Dr Jonathan Samet, Principal Investigator) of Johns Hopkins Bloomberg School of Public Health, Baltimore MD. This latest report from the National Morbidity, Mortality, and Air Pollution Study examines the question of whether there is a threshold below which there does not appear to be an association between particulate matter levels and mortality.  It presents as well the perspective of the HEI Review Committee on the results.  Click here to download Report 94 Part III or the HEI Statement.

Now available: Special Report 15 – May 2004
Health Effects of Outdoor Air Pollution in Developing Countries of Asia

This first publication to come from HEI's Public Health and Air Pollution in Asia (PAPA) Program was undertaken to help inform the Clean Air Initiative for Asian Cities. This special report has identified and summarized more than 135 studies of air pollution and health conducted across Asia. In addition, it critically reviews for the first time a key subset of these studies: 28 studies of daily mortality. To download the report or an executive summary please click here
Press Release

HEI publishes report on Manganese Transport into the Brain – January 2004
This report describes a study on manganese, a component of the fuel additive MMT. Manganese is an essential nutrient and part of the daily diet, but also causes neurotoxic symptoms in workers that inhale high concentrations.  The investigators studied the mechanism by which manganese may enter and leave the brain of laboratory rats across its protective blood-brain barrier to try to understand whether there are mechanisms that would allow or, alternatively, prevent accumulation of manganese in the brain with prolonged exposure to low levels in the environment. Click here to download Research Report 119, Manganese Toxicokinetics at the Blood-Brain Barrier, or the HEI Statement (a short synopsis).

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» Dan Greenbaum

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Last updated November 08, 2004