Virus Code. 61.0.6. Virus Accession number 61060000.
Comments: Five serogroups of lentiviruses are recognised, reflecting
the hosts with which they are associated (primates, sheep and goats, horses,
cats, and cattle). The primate lentiviruses are distinguished by the use of
CD4 protein as receptor and the absence of DU. Some groups have cross-reactive
gag antigens (e.g., the ovine, caprine and feline lentiviruses). Antibodies to
gag antigens in lions and other large felids indicate the existence of other
viruses related to FIV and the ovine/caprine lentiviruses.
Virus infects vertebrates.
Description is on taxonomic level of genus. Virus belongs to the family
Virions enveloped; slightly
pleomorphic; spherical; 80-100 nm in diameter. Surface projections of envelope
small (surface appears rough), or barely visible; spikes (of about 8nm);
dispersed evenly over all the surface. Nucleocapsids (cores) isometric.
Nucleoid concentric and rod-shaped, or shaped like a truncated cone.
Virions contain 2
% nucleic acid. Genome consists of a dimer. Virions contain one molecule of
(each) linear positive-sense single stranded RNA.
Total genome length is of one monomer 9200 nt. Genome sequence has terminal
repeated sequences; long terminal repeats (LTR) (of about 600 nt. The 5' end
of the genome has a cap. Cap sequence of type 1 m7G5ppp5'GmpNp. 3' end of each
monomer has a poly (A) tract; 3'-terminus has a tRNA-like structure (and
accepts lysin). Encapsidated nucleic acid solely genomic. 2 copies packed per
particle (held together by hydrogen bonds to form a dimer).
Virions contain 60 %
protein. Five structural virion proteins found (major). Protein size 120000
Da. Gp120 glycosylated surface envelope protein SU, encoded by the viral gene
env. Protein size of 2nd largest 41000 Da. Gp41 glycosylated
transmembrane envelope protein TM, also encoded by the viral gene env.
Protein size of 3rd largest 24000 Da. P24 non-glycosylated capsid protein CA.
Protein size of 4th largest 17000 Da. P17 non-glycosylated matrix protein MA.
Protein size of 5th largest 7000-11000 Da. Non-glycosylated capsid protein NC.
Proteins MA, CA and NA are all encoded by the gag gene. Virion
structural proteins are glycosylated. Are the following: the envelope proteins
SU and TM. Usually four non-structural proteins found, or three non-structural
proteins found (in the primate lentiviruses). Protein size 66000 Da. Reverse
transcriptase RT encoded by the pol gene. Protein size of 2nd largest
32000 Da. Integrase IN also encoded by the pol gene. Protein size of
3rd 14000 Da. Protease PR encoded by the pro gene. dUPTase DU, role
Features of the genome: infectious viruses have 4 main genes coding for the
virion proteins in the order:
5´-gag-pro-pol-env-3´. There are additional genes
depending on the virus (e.g., for HIV-1: vif, vpr, vpu, tat, rev,
nef) whose products are involved in regulation of synthesis and processing
virus RNA and other replicative functions. The LTR is about 600nt long, of
which the U3 region is 450, the R sequence 100 and the U5 region some 70 nt
determinants are type-specific and group-specific. Antigen determinants that
possess type-specific reactivity are found on the envelope. Antigen
determinants that possess type-specific reactivity are found on the
glycoproteins. Are involved in antibody mediated neutralization.
Cross-reactivity found. Cross-reactivity among some species of the same
serotype, but (but not between members of different genera). Classification of
members of this taxon infrequently based on their antigenic properties.
Host of virus
belongs to the Domain Eucarya. Host of virus belongs to the Kingdom Animalia.
Phylum Chordata. Subphylum Vertebrata. Class Mammalia. Order Primates,
Perissodactyla, Carnivora, and Artiodactyla.
Taxonomic structure of the genus. Serogroup: Subgroup
Bovine lentivirus group (VC
), Subgroup Equine
lentivirus group (VC
), Subgroup Feline lentivirus
), Subgroup Ovinecaprine lentivirus group (VC
), and Subgroup Primate lentivirus group (VC
). Type species:
The above description has been compiled from the data presented
in the Sixth ICTV Report by Coffin JM, Essex M, Gallo R, Graf TM,
Hinuma Y, Hunter E, Jaenisch R, Nusse R, Oroszlan S, Svoboda J, Teich N,
Toyoshima K, Varmus H.
description has been generated automatically from DELTA files.
ICTVdB - The Universal Virus
Database, developed for the International Committee on Taxonomy of
Viruses (ICTV) by
Dr Cornelia Büchen-Osmond, is written in DELTA. The virus descriptions
in ICTVdB are coded by ICTV members and experts, or by the
ICTVdB Management using data provided by the experts, the literature or the
latest ICTV Report. The character list is the
underlying code. All virus descriptions are based on the character list and
natural language translations from the encoded descriptions are automatically
generated and formatted for display on the Web.