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Dr. Amy Bishop
Assistant Professor
Department of Biological Sciences
     
Research Areas
 
   
Research Description

The free radical gas, nitric oxide (NO), is synthesized by many mammalian cells and is utilized for a variety of functions such as cellular signaling, neurotransmission, differentiation and as a bactericidal agent. At high levels, such as during induction of inducible nitric oxide synthase (iNOS), NO is toxic and plays a role in the pathology of injury and many diseases. It is also car cinogenic and mutagenic. Release of NO and other oxidants is implicated in the massive cell death (apoptosis) of motor neurons and their support cells, oligodendrocytes, after spinal injury. In many neurodegenerative diseases, including AIDS dementia, Amyotrophic Lateral Sclerosis (ALS) and Alzheimer's, NO-mediated damage is seen.

Understanding mechanisms of induced adaptive resistance in the CNS has therapeutic potential to prevent carcinogenesis as well as preserve cells during early stages of disease (ALS etc.) and during injury (stroke, spinal cord transection). Elucidation of these mechanisms will also give us insights into stimulating regenerative processes in the CNS.

Oxidative Stress Publications



 
 
 
 
     
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