Chemical Leukodystrophy

What Relationship Between Leukodystrophy and Chlorinated Hydrocarbon?

Start with little gems like this attempt of the Editor to describe this collection of articles about peroxide chemistry titled: Peroxide Chemistry Editor: Waldemar Adam (Universität Würzburg)

The emphasis was to lie on the development of environmentally acceptable, selective (chemo-, regio-, diastereo- and enantioselectivity) oxidations. One chapter focuses on industrial applications which have to meet both economical and ecological demands to remain competitive in the future. Latest results on the consequences of lipid peroxidation in age-dependent diseases, which range from Alzheimer and Parkinson disorders to diabetes, rheumatic arthritis, atherosclerosis and cardiovascular diseases are also presented.

I'm just a layman when it comes to chemistry but books with this type of abstract catch my attention.

Here is another flag raiser. From a document reporting findings in workers exposed to solvents.

A high degree of correlation was found in the exposed group between the symptoms and the results of electromyoneurographic findings....Segmental demyelination results from primary destruction of the neuronal myelin sheath, with the relative sparing of the axons.

Another interesting find is: Study of Health Outcomes in Aircraft Maintenance Personnel (SHOAMP)This is just phase one the review of available literature. I highly recommend reading this before diving into any other literature on the subject

All this is good but it does not speak to why Leukodystrophy always looks genetic or why no one even asks about exposure to solvents in a differential diagnosis process. So should Solvent exposure of parents be considered when neurological problems surface? So far If I was a doctor reading doctor stuff I'd say No don't waste more than a minute going there. You should however take a good look at this article. Organic Solvents: Author: Jonathan S Rutchik, MD, MPH, Assistant Professor, Department of Occupational and Environmental Medicine, University of California at San Francisco

Can Solvents mess with DNA?

Start here if you can afford the money to read it or time to get to a library. The pathogenesis of neurodegenerative disease: neurotoxic mechanisms of action and genetics. Current Opinion in Neurology. 12(6):725-731, December 1999. Feldman, Robert G. a,b,c,d; Ratner, Marcia H. e

Try searching for DNA in this article.ORGANIC SOLVENT NEUROTOXICITY it is just a brief mention of a possibility of interaction with DNA and RNA. Who knows what it means?

This document concludes: With the possible exception of the equivocal results for chromosomal aberrations observed in female rats following inhalation (McGregor, 1980), the weight of evidence overall indicates that 1,1,2,2-tetrachloroethane is not genotoxic or that it is only weakly genotoxic, acting through a mechanism that results in gene conversion and induction of sister chromatid exchange.

The evidence seems to point out that at worst these agents may only effect individuals that are genetically predisposed. Then again I'm not a doctor so this is not much of an opinion. :) I have a lot of work to do on this page. there are two things I'd like to do.

  1. Create a map and time-line that helps to visualize if a relationship can be found between the history of the manufacture of chlorinated hydrocarbons and the documented cases of leukodystrophy
  2. Compile a list of parents' of affected children, their occupations and geographic location.
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