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Strain Name: BALB/cByJ
Stock Number: 001026
Availability: Level 1

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Strain Common Names      BALB Bailey;      BALB/c Bailey J;
Genes & Alleles   Cdh23;   Cdh23ahl;   Mdmg1;   ;


Product Information

Strain Details

Type Inbred Strain
Additional information on Inbred Strains.
TJL Mating SystemSibling x Sibling         (Female x Male)
Specieslaboratory mouse
H2 Haplotyped
GenerationF235 (16-NOV-05)

Appearance
albino
Related Genotype: A/A Tyrp1b/Tyrp1b Tyrc/Tyrc

Important Note
This strain is homozygous for Cdh23ahl, the age related hearing loss 1 mutation, which on this background results in progressive hearing loss with onset after 10 months of age.

Strain Description
According to the description in Michael Festing's list of Inbred Strains of mice (see link below), BALB/c mice are particularly well known for the production of plasmacytomas on injection with mineral oil forming the basis for the production of monoclonal antibodies. The information in Festing's list does not specifcy which BALB/c substrain(s) have been examined for plasmacytoma induction. Mammary tumor incidence is normally low but infection with mammary tumor virus by fostering to MMTV+ C3H mice dramatically increases tumor number and age of onset. BALB/c mice develop other cancers later in life including reticular neoplasms, primary lung tumors, and renal tumors. Rare spontaneous myoepitheliomas arising from myoepithelial cells of various exocrine glands have been observed in both BALB/cJ and BALB/cByJ substrains. BALB/cByJ has a deletion in the Qa2 subregion of the murine MHC.

Gene & Allele Details

Allele Symbol Cdh23ahl
Allele Name age related hearing loss 1
Common Name(s) Cdh23753A; mdfw;
Strain of OriginC57BL/6J
Gene Symbol and Name Cdh23, cadherin 23 (otocadherin)
Chromosome 10
Gene Common Name(s) 4930542A03Rik; DFNB12; DKFZp434P2350; FLJ00233; FLJ36499; KIAA1774; KIAA1812; MGC102761; RIKEN cDNA 4930542A03 gene; USH1D; W; age related hearing loss 1; ahl; ahl1; bob; bobby; bus; bustling; mdfw; modifier of deaf waddler; neuroscience mutagenesis facility, 112; neuroscience mutagenesis facility, 181; neuroscience mutagenesis facility, 252; nmf112; nmf181; nmf252; v; waltzer;
Molecular Note Genetic complementation tests have shown allelism between the mdfw (modifier of deaf waddler) locus and the ahl locus. Further analysis has identified an association between ahl and a G to A transition at nucleotide position 753 of Cdh23. This hypomorphic allele causes in frame skipping of exon 7 and reduced message stability. Twenty-seven strains classified with ahl and carrying the 753A allele include: CD1, RBF/DnJ, PL/J, AKR/J, RF/J, BALB/cBy, A/WySnJ, P/J, SENCARA/PtJ, DBA/1J, ALS/LtJ, C58/J, C57BLKS/J, 129/ReJ, C57BR/cd, SKH2/J, BUB/Bn, MA/MyJ, LP/J, 129/ScJ, NOR/LtJ, A/J, C57BL/6, NOD/LyJ, DBA/2J, ALR/LtJ, C57L/J. Strains classified with ahl that DO NOT carry this mutation include: C3H/HeSnJ, I/LnJ,YBR/Ei, MRL/MpJ.
Gene Symbol and Name Mdmg1, mandibular morphogenesis 1
Chromosome 17
Gene Common Name(s) Mdmg-1;

Colony Maintenance

Diet Information LabDiet® 5K52/5K67

Related Strains

BALB Strains
000650   BALB/cBy
001905   BALB/cGaJ
000921   BALB/cGrRkJ
000651   BALB/cJ
001311   BALB/cWtEiJ
View BALB Strains     (5 strains)

Strains carrying   Cdh23ahl allele
001137   129P1/ReJ
000690   129P3/J
002065   129T2/SvEmsJ
000691   129X1/SvJ
000646   A/J
000647   A/WySnJ
003070   ALR/LtJ
003072   ALS/LtJ
004502   B6;AKR-Lxl2/J
000653   BUB/BnJ
005494   C3.129S1(B6)-rcw/J
000664   C57BL/6J
004764   C57BL/6J-Cdh23v-8J/J
003129   C57BL/6J-Epha4rb-2J/J
004820   C57BL/6J-Kcne12J/J
004703   C57BL/6J-Nmf134/J
004811   C57BL/6J-nmf110/J
004812   C57BL/6J-nmf111/J
004747   C57BL/6J-nmf118/J
004656   C57BL/6J-nmf88/J
004391   C57BL/6J-Chr 13A/J/NaJ
004385   C57BL/6J-Chr 7A/J/NaJ
000662   C57BLKS/J
000667   C57BR/cdJ
000668   C57L/J
000669   C58/J
000657   CE/J
000670   DBA/1J
001140   DBA/1LacJ
000671   DBA/2J
002106   KK/HlJ
000675   LG/J
000676   LP/J
000677   MA/MyJ
001976   NOD/LtJ
002050   NOR/LtJ
000679   P/J
002747   SENCARB/PtJ
002335   SKH2/J
003392   STOCK Crb1rd8/J
View Strains carrying   Cdh23ahl     (40 strains)

Phenotypic Data
Body Weight Information - JAX® Mice Strain BALB/cByJ (001026)
(This chart reflects the typical correlation between body weight and age for mice maintained in production colonies at The Jackson Laboratory.)
Mouse Phenome Database
Mouse Phenome Database - MHC H2 haplotype
Mouse Phenome Database - body weight
Mouse Phenome Database - exploratory behavior
Mouse Phenome Database - food and water intake
Mouse Phenome Database - hematology
Mouse Phenome Database - reproductive performance
Mouse Phenome Database / SNP Facility
Festing Inbred Strain Characteristics: BALB/c

Additional Web Information

Genetic Quality Control Annual Report
JAX Notes, April 1988; 433. H-2 Haplotypes of Mice from Jackson Laboratory Production Colonies.
JAX Notes, Fall 1990; 443. A Brief History of the Two Substrains of BALB/c, BALB/cJ, and BALB/cByJ Available from Animal Resources.
JAX Notes, Fall 1990; 443. Ulcerative Blepharitis and Periorbital Abscesses in BALB/cJ and BALB/cByJ Mice.
JAX Notes, July 1987; 430. BALB/cJ vs. BALB/cByJ.
JAX Notes, Spring 2003; 489. Malocclusion in the Laboratory Mouse.
JAX Notes, Summer 1992; 450. Myoepitheliomas in Inbred Laboratory Mice.
JAX Notes, Summer 2003; 490. Hydrocephalus in Laboratory Mice.

Animal Health Reports
Room Number           MP13
Room Number           MP14

Research Applications

This mouse can be used to support research in many areas including:

Cancer Research
Increased Tumor Incidence (Mammary Gland Tumors: late onset)

Immunology and Inflammation Research
Autoimmunity (experimental allergic encephalomyelitis (EAE))

Neurobiology Research
Neurodevelopmental Defects (callosal agenesis, incomplete penetrance)
Vestibular and Hearing Defects (Age related hearing loss)

Research Tools
Cancer Research (monoclonal antibodies, myeloma and hybridoma production)
General Purpose
Immunology and Inflammation Research (background strain for histocompatibility congenics)

Sensorineural Research
Vestibular and Hearing Defects (Age related hearing loss)

References
Additional References

Price and Supply Information

Strain Name: BALB/cByJ
Stock Number: 001026

Price Details

IMPORTANT NOTE: Prices are based on shipping destination. The shipping destinations are:

*Pricing for Shipping Destination selected:

        International

Price(s) in US dollars ($)Genotype(s) Provided
Base Price (3-5 weeks) $15.60 Male
Base Price (3-5 weeks) $17.10 Female
6 weeks $17.90 Male
6 weeks $19.40 Female
7 weeks $20.20 Male
7 weeks $21.70 Female
8 weeks $22.50 Male
8 weeks $24.00 Female

Supply Details

Standard SupplyLevel 1. Readily Available.
Supply Notes Shipped at a specific age in weeks. Mice at a precise age in days, littermates and retired breeders are also available.
Strains that must be genotyped are not available until five to seven weeks of age.
Genomic DNA is available for this strain from the Mouse DNA Resource.
LicensingSee General Terms and Conditions of Sale below  

General Terms and Conditions of Sale

View JAX® Mice Conditions of Use.

The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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