|Strain Common Names||BALB Bailey; BALB/c Bailey J;|
|Genes & Alleles||Cdh23; Cdh23ahl; Mdmg1; ;|
Type Inbred Strain Additional information on Inbred Strains. TJL Mating System Sibling x Sibling (Female x Male) Species laboratory mouse H2 Haplotype d Generation F235 (16-NOV-05)
Related Genotype: A/A Tyrp1b/Tyrp1b Tyrc/Tyrc
This strain is homozygous for Cdh23ahl, the age related hearing loss 1 mutation, which on this background results in progressive hearing loss with onset after 10 months of age.
According to the description in Michael Festing's list of Inbred Strains of mice (see link below), BALB/c mice are particularly well known for the production of plasmacytomas on injection with mineral oil forming the basis for the production of monoclonal antibodies. The information in Festing's list does not specifcy which BALB/c substrain(s) have been examined for plasmacytoma induction. Mammary tumor incidence is normally low but infection with mammary tumor virus by fostering to MMTV+ C3H mice dramatically increases tumor number and age of onset. BALB/c mice develop other cancers later in life including reticular neoplasms, primary lung tumors, and renal tumors. Rare spontaneous myoepitheliomas arising from myoepithelial cells of various exocrine glands have been observed in both BALB/cJ and BALB/cByJ substrains. BALB/cByJ has a deletion in the Qa2 subregion of the murine MHC.
|Allele Name||age related hearing loss 1|
|Common Name(s)||Cdh23753A; mdfw;|
|Strain of Origin||C57BL/6J|
|Gene Symbol and Name||Cdh23, cadherin 23 (otocadherin)|
|Gene Common Name(s)||4930542A03Rik; DFNB12; DKFZp434P2350; FLJ00233; FLJ36499; KIAA1774; KIAA1812; MGC102761; RIKEN cDNA 4930542A03 gene; USH1D; W; age related hearing loss 1; ahl; ahl1; bob; bobby; bus; bustling; mdfw; modifier of deaf waddler; neuroscience mutagenesis facility, 112; neuroscience mutagenesis facility, 181; neuroscience mutagenesis facility, 252; nmf112; nmf181; nmf252; v; waltzer;|
|Molecular Note||Genetic complementation tests have shown allelism between the mdfw (modifier of deaf waddler) locus and the ahl locus. Further analysis has identified an association between ahl and a G to A transition at nucleotide position 753 of Cdh23. This hypomorphic allele causes in frame skipping of exon 7 and reduced message stability. Twenty-seven strains classified with ahl and carrying the 753A allele include: CD1, RBF/DnJ, PL/J, AKR/J, RF/J, BALB/cBy, A/WySnJ, P/J, SENCARA/PtJ, DBA/1J, ALS/LtJ, C58/J, C57BLKS/J, 129/ReJ, C57BR/cd, SKH2/J, BUB/Bn, MA/MyJ, LP/J, 129/ScJ, NOR/LtJ, A/J, C57BL/6, NOD/LyJ, DBA/2J, ALR/LtJ, C57L/J. Strains classified with ahl that DO NOT carry this mutation include: C3H/HeSnJ, I/LnJ,YBR/Ei, MRL/MpJ.|
|Gene Symbol and Name||Mdmg1, mandibular morphogenesis 1|
|Gene Common Name(s)||Mdmg-1;|
|Diet Information||LabDiet® 5K52/5K67|
View BALB Strains (5 strains)Strains carrying Cdh23ahl allele
001137 129P1/ReJ 000690 129P3/J 002065 129T2/SvEmsJ 000691 129X1/SvJ 000646 A/J 000647 A/WySnJ 003070 ALR/LtJ 003072 ALS/LtJ 004502 B6;AKR-Lxl2/J 000653 BUB/BnJ 005494 C3.129S1(B6)-rcw/J 000664 C57BL/6J 004764 C57BL/6J-Cdh23v-8J/J 003129 C57BL/6J-Epha4rb-2J/J 004820 C57BL/6J-Kcne12J/J 004703 C57BL/6J-Nmf134/J 004811 C57BL/6J-nmf110/J 004812 C57BL/6J-nmf111/J 004747 C57BL/6J-nmf118/J 004656 C57BL/6J-nmf88/J 004391 C57BL/6J-Chr 13A/J/NaJ 004385 C57BL/6J-Chr 7A/J/NaJ 000662 C57BLKS/J 000667 C57BR/cdJ 000668 C57L/J 000669 C58/J 000657 CE/J 000670 DBA/1J 001140 DBA/1LacJ 000671 DBA/2J 002106 KK/HlJ 000675 LG/J 000676 LP/J 000677 MA/MyJ 001976 NOD/LtJ 002050 NOR/LtJ 000679 P/J 002747 SENCARB/PtJ 002335 SKH2/J 003392 STOCK Crb1rd8/JView Strains carrying Cdh23ahl (40 strains)
Body Weight Information - JAX® Mice Strain BALB/cByJ (001026)Mouse Phenome Database
(This chart reflects the typical correlation between body weight and age for mice maintained in production colonies at The Jackson Laboratory.)
Mouse Phenome Database - MHC H2 haplotype
Mouse Phenome Database - body weight
Mouse Phenome Database - exploratory behavior
Mouse Phenome Database - food and water intake
Mouse Phenome Database - hematology
Mouse Phenome Database - reproductive performance
Mouse Phenome Database / SNP Facility
Festing Inbred Strain Characteristics: BALB/c
Genetic Quality Control Annual Report
JAX Notes, April 1988; 433. H-2 Haplotypes of Mice from Jackson Laboratory Production Colonies.
JAX Notes, Fall 1990; 443. A Brief History of the Two Substrains of BALB/c, BALB/cJ, and BALB/cByJ Available from Animal Resources.
JAX Notes, Fall 1990; 443. Ulcerative Blepharitis and Periorbital Abscesses in BALB/cJ and BALB/cByJ Mice.
JAX Notes, July 1987; 430. BALB/cJ vs. BALB/cByJ.
JAX Notes, Spring 2003; 489. Malocclusion in the Laboratory Mouse.
JAX Notes, Summer 1992; 450. Myoepitheliomas in Inbred Laboratory Mice.
JAX Notes, Summer 2003; 490. Hydrocephalus in Laboratory Mice.
This mouse can be used to support research in many areas including:
Increased Tumor Incidence (Mammary Gland Tumors: late onset)
Immunology and Inflammation Research
Autoimmunity (experimental allergic encephalomyelitis (EAE))
Neurodevelopmental Defects (callosal agenesis, incomplete penetrance)
Vestibular and Hearing Defects (Age related hearing loss)
Cancer Research (monoclonal antibodies, myeloma and hybridoma production)
Immunology and Inflammation Research (background strain for histocompatibility congenics)
Vestibular and Hearing Defects (Age related hearing loss)
IMPORTANT NOTE: Prices are based on shipping destination. The shipping destinations are:
|Price(s) in US dollars ($)||Genotype(s) Provided|
|Base Price (3-5 weeks)||$15.60||Male|
|Base Price (3-5 weeks)||$17.10||Female|
|Standard Supply||Level 1. Readily Available.|
Shipped at a specific age in weeks. Mice at a precise age in days, littermates and retired breeders are also available.|
Strains that must be genotyped are not available until five to seven weeks of age.
Genomic DNA is available for this strain from the Mouse DNA Resource.
|Licensing||See General Terms and Conditions of Sale below|