iPhone Photo Gallery at Engadget | Add to My AOL, MyYahoo, Google, Bloglines

Note: The contents of this blog are for informational purposes only and should not be construed as medical advice or substitute for professional care. For medical emergencies, dial 911!

Uncertain future for drug used to shrink tumors

Canadian researcher Evangelos Michelakis, associate professor of medicine at the University of Alberta in Edmonton, has stumbled upon something quite remarkable -- a potentially new anti-cancer agent called dichloroacetate, or DCA.

DCA is nothing new -- it's long been used for treatment of rare metabolic disorders -- but using it to fight cancer puts an entirely new spin on the potential of this drug.

"This is one of the most exciting results I've ever had," Michelakis said. "But I can't be overenthusiastic until it works on a human."

Michelakis and his colleagues have successfully used DCA to shrink human lung, breast, and brain tumors in both lab rats and test tubes. And while this type of research may not ordinarily generate a lot of excitement, this specific study is creating a buzz because DCA has been safely used in humans for decades, without adverse side effects.

"One of the big concerns about drugs is that they can harm people but we already know this drug is safe," Michelakis says. "It doesn't even affect normal cells."

One of the fundamental premises of cancer biology is that mitochondria -- the energy producing units of cells -- are permanently damaged by cancer. What DCA does is revive the mitochondrial function, encouraging the death of cancer cells.

The overwhelming hope is that DCA will move right to human testing. But the overwhelming fear is that it will not -- because of economic reasons. There is no longer a patent on DCA so it is not owned by any one company. With little chance of one group making a large profit, there may be no incentive for pharmaceutical companies to invest in research.

Sadly, this drug -- that appears to work remarkably well -- may never benefit cancer patients. All because no one stands to make billions of dollars from it.

Recent Posts

Reader Comments

(Page 1)

1. This is where Lance Armstrong needs to step up and put some of that LiveSTrong money on the line.
I don't see much of anything else being done with that money, I tried to get a scholarship to retrain after cancer, and never got an answer from them. So let him use that braclet money on DCA and give us all something to hope for.

Posted at 6:04PM on Jan 24th 2007 by Brit 0 stars

Add your comments

Please keep your comments relevant to this blog entry: inappropriate or purely promotional comments may be removed. Email addresses are never displayed, but they are required to confirm your comments. To create a live link, simply type the URL (including http://) or email address and we will make it a live link for you. You can put up to 3 URLs in your comments. Line breaks and paragraphs are automatically converted — no need to use <p> or <br> tags.

Your name (required):

Your email address (required, will not be shown to the public):

Your site’s URL (optional):

Do you want us to remember your personal information for next time?
   
Add your comments:

Types of Cancer
 (0)
All Cancers (496)
Animal (15)
Bladder Cancer (33)
Blood Cancer (12)
Bone Cancer (7)
Brain Cancer (88)
Breast Cancer (1055)
Cervical Cancer (45)
Childhood Cancers (184)
Colon and Rectal Cancer (167)
Endometrial Cancer (23)
Esophageal Cancer (21)
Eye Cancer (6)
Gallbladder Cancer (1)
Gastric cancer (4)
Germ Cell Tumors (1)
Head and Neck cancer (6)
Hodgkin's Lymphoma (45)
Kidney Cancer (42)
Leukemia (115)
Liver Cancer (24)
Lung Cancer (214)
Melanoma (86)
Mouth Cancer (40)
Multiple Myeloma (11)
Neuroblastoma (1)
Non-Hodgkins Lymphoma (46)
Oral Cancer (10)
Ovarian Cancer (135)
Pancreatic Cancer (46)
Pet Cancers (8)
Pregnancy and cancer (5)
Prostate Cancer (173)
Rectal Cancer (2)
Sarcoma (5)
Skin Cancer (85)
Stomach Cancer (17)
Teen Cancers (20)
Testicular Cancer (12)
Throat Cancer (9)
Thymic Cancer (0)
Thyroid Cancer (42)
Tissue Cancers (1)
Tongue Cancer (1)
Unknown Primary (1)
Uterine Cancer (8)
Young Adult Cancers (74)
Treatment
Alternative Therapies (382)
Cancer Caregivers (54)
Cancer Pre-vivors (3)
Cancer Survivors (291)
Chemotherapy (420)
Clinical Trials (102)
Drug (395)
Hospice (7)
Prevention (1162)
Radiation (58)
Stem Cell (22)
Cancer Fundraisers
 (0)
Cancer events (104)
Pink products (49)
Celebrities
Celebrity cancer diagnosis (52)
Celebrity fundraisers (75)
Celebrity in memoriam (54)
Celebrity news (119)
Celebrity spokesperson (39)
News
Daily news (405)
Events (73)
Fundraisers (114)
Opinion (123)
Politics (86)
Research (521)
Prevention
Cancer prevention foods (106)
Diets (102)
Environment (73)
Exercise (54)
Non-toxic alternatives (23)
Nutrition (75)
Obesity (32)
Smoking (52)
Stress Reduction (62)
Vitamins and nutrients (54)
Media
Blogs (102)
Books (89)
Magazines (26)
Movies (11)
Products (113)
Services (73)
Television (81)
Video games (3)
Features
RetroReview (5)
Saturday Six (4)
Sunday Seven (31)
Survivor Spotlight (25)
Cancer by the Numbers (9)
Recipe Healthy Living (29)
Healing Attitude Almanac (6)
Meet the Bloggers
Bloggers (7)
Jacki Donaldson (1)
Kristina Collins (1)
Diane Rixon (1)
Nine DeJanvier (1)
Chris Sparling (1)
Allie Beatty (1)
Dalene Entenmann (1)

RESOURCES

RSS NEWSFEEDS

Powered by Blogsmith

Sponsored Links

The Cancer Blog bloggers (30 days)

#BloggerPostsCmts
1Jacki Donaldson840
2Kristina Collins370
3Dalene Entenmann310
4Vicki Blankenship20

The Cancer Blog Contributors

#ContributorStarsCmts
1Dalene168
2Dr Emer11

Most Commented On (60 days)

Recent Comments

Weblogs, Inc. Network

ConsumerAdd RSS
AdJabAOL | Yahoo
AutoblogAOL | Yahoo
AutoblogGreenAOL | Yahoo
Autoblog SpanishAOL | Yahoo
Autoblog ChineseAOL | Yahoo
Autoblog Simplified ChineseAOL | Yahoo
Blogging BabyAOL | Yahoo
Card SquadAOL | Yahoo
CinematicalAOL | Yahoo
Download SquadAOL | Yahoo
Divester (scuba)AOL | Yahoo
EngadgetAOL | Yahoo
Engadget MobileAOL | Yahoo
Engadget ChineseAOL | Yahoo
Engadget Simplified ChineseAOL | Yahoo
Engadget JapaneseAOL | Yahoo
Engadget SpanishAOL | Yahoo
HD BeatAOL | Yahoo
JoystiqAOL | Yahoo
LuxistAOL | Yahoo
PVR WireAOL | Yahoo
SlashfoodAOL | Yahoo
StyledashAOL | Yahoo
That's FitAOL | Yahoo
TUAW (Apple)AOL | Yahoo
TV SquadAOL | Yahoo

Technology

Add RSS
CSS InsiderAOL | Yahoo
Digital PhotographyAOL | Yahoo
Flash InsiderAOL | Yahoo
Google (Unofficial)AOL | Yahoo
JavaScriptAOL | Yahoo
Microsoft (Unofficial)AOL | Yahoo
OfficeAOL | Yahoo
Open SourceAOL | Yahoo
Peer-to-PeerAOL | Yahoo
Photoshop (Unofficial)AOL | Yahoo
RSSAOL | Yahoo
SAS (Unofficial)AOL | Yahoo
Search Engine MarketingAOL | Yahoo
Social SoftwareAOL | Yahoo
Tablet PCsAOL | Yahoo
TUAW (Apple)AOL | Yahoo
VoIPAOL | Yahoo
Yahoo (Unofficial)AOL | Yahoo

Travel/Destinations

Add RSS
GadlingAOL | Yahoo
Blogging New OrleansAOL | Yahoo
Blogging OhioAOL | Yahoo

Wireless

Add RSS
BBHub (BlackBerry)AOL | Yahoo
Engadget MobileAOL | Yahoo
Engadget: GPSAOL | Yahoo
Engadget: WirelessAOL | Yahoo
The Wireless ReportAOL | Yahoo

Video Games

Add RSS
Blogging E3AOL | Yahoo
DS FanboyAOL | Yahoo
Engadget: GamingAOL | Yahoo
JoystiqAOL | Yahoo
Nintendo Wii FanboyAOL | Yahoo
PS3 FanboyAOL | Yahoo
PSP FanboyAOL | Yahoo
Second Life InsiderAOL | Yahoo
WoW InsiderAOL | Yahoo
Xbox 360 FanboyAOL | Yahoo

Media & Entertainment

Add RSS
CinematicalAOL | Yahoo
DesignAOL | Yahoo
Digital MusicAOL | Yahoo
Droxy (Digital Radio)AOL | Yahoo
DV Guru (Digital Video)AOL | Yahoo

Finance

Add RSS
Blogging StocksAOL | Yahoo
Apple (AAPL)AOL | Yahoo
eBay (EBAY)AOL | Yahoo
Genl Electric (GE)AOL | Yahoo
Google (GOOG)AOL | Yahoo
Microsoft (MSFT)AOL | Yahoo
Time Warner (TWX)AOL | Yahoo
Wal Mart (WMT)AOL | Yahoo
Yahoo! (YHOO)AOL | Yahoo

Business

Add RSS
MortgagesAOL | Yahoo

Life Sciences

Add RSS
The Cancer BlogAOL | Yahoo
The Cardio BlogAOL | Yahoo
The Diabetes BlogAOL | Yahoo
Medical Informatics InsiderAOL | Yahoo

Personal

Add RSS
Brian AlveyAOL | Yahoo
Jason CalacanisAOL | Yahoo
Judith MeskillAOL | Yahoo
Ted LeonsisAOL | Yahoo

Events

Add RSS
Blogging BlogHerAOL | Yahoo
Blogging DEMOAOL | Yahoo
Blogging E3AOL | Yahoo
Blogging ETechAOL | Yahoo
Blogging GnomedexAOL | Yahoo
Future of MusicAOL | Yahoo
Blogging MilkenAOL | Yahoo
Blogging SundanceAOL | Yahoo
Blogging Web 2.0AOL | Yahoo
Live 8 InsiderAOL | Yahoo

On Hiatus/Retired

Add RSS
Telemedicine InsiderAOL | Yahoo
SCM Wire (supply chain)AOL | Yahoo
BluetoothAOL | Yahoo
RFIDAOL | Yahoo
Ultra WidebandAOL | Yahoo
WiFiAOL | Yahoo
The WiMAX WeblogAOL | Yahoo
Wireless DevAOL | Yahoo
WirelessAOL | Yahoo
Documentary FilmAOL | Yahoo
Enron BlogAOL | Yahoo
Independent FilmAOL | Yahoo
Magazine DesignAOL | Yahoo
NanopublishingAOL | Yahoo
SpamAOL | Yahoo
Unofficial Playstation 3AOL | Yahoo
Unofficial Xbox2AOL | Yahoo
Video GamesAOL | Yahoo

Other

Add RSS
Weblogs, Inc.AOL | Yahoo

Powered by Blogsmith

Add RSS
Paper MagazineAOL | Yahoo
Razor MagazineAOL | Yahoo

Other Weblogs Inc. Network blogs you might be interested in: