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Type Inbred Strain Additional information on Inbred Strains. TJL Mating System Sibling x Sibling (Female x Male) Species laboratory mouse H2 Haplotype d Generation F221 (14-DEC-06)
Related Genotype: A/A Tyrp1b/Tyrp1b Tyrc/Tyrc
According to the description in Michael Festing's list of Inbred Strains of mice (see link below), BALB/c mice are particularly well known for the production of plasmacytomas on injection with mineral oil forming the basis for the production of monoclonal antibodies. The information in Festing's list does not specify which BALB/c substrain(s) have been examined for plasmacytoma induction. Mammary tumor incidence is normally low but infection with mammary tumor virus by fostering to MMTV+ C3H mice dramatically increases tumor number and age of onset. BALB/c mice develop other cancers later in life including reticular neoplasms, primary lung tumors, and renal tumors. Rare spontaneous myoepitheliomas arising from myoepithelial cells of various exocrine glands have been observed in both BALB/cJ and BALB/cByJ substrains.
White et al. reported a variation in thioglycolate medium-induced peritoneal leukocyte recruitment in 4 analyzed strains. The response of total leukocyte recruitment, from greatest to least, was C57BL/6J>BALB/c>CD1>129X1/SvJ. Variations were also found in the timeline of response and cell types most impacted.
|Diet Information||LabDiet® 5K52/5K67|
000650 BALB/cBy 001026 BALB/cByJ 001905 BALB/cGaJ 000921 BALB/cGrRkJ 001311 BALB/cWtEiJView BALB Strains (5 strains)
UPDATED Body Weight Information - JAX® Mice Strain BALB/cJ (000651)Mouse Phenome Database
(This chart reflects the typical correlation between body weight and age for mice maintained in production colonies at The Jackson Laboratory.)
Mouse Phenome Database - MHC H2 haplotype
Mouse Phenome Database - body weight
Mouse Phenome Database - cardiovascular
Mouse Phenome Database - disease susceptibility
Mouse Phenome Database - food and water intake
Mouse Phenome Database - hematology
Mouse Phenome Database / SNP Facility
Festing Inbred Strain Characteristics: BALB/c
Genetic Quality Control Annual Report
JAX Notes, April 1988; 433. H-2 Haplotypes of Mice from Jackson Laboratory Production Colonies.
JAX Notes, Fall 1990; 443. A Brief History of the Two Substrains of BALB/c, BALB/cJ, and BALB/cByJ Available from Animal Resources.
JAX Notes, Fall 1990; 443. Ulcerative Blepharitis and Periorbital Abscesses in BALB/cJ and BALB/cByJ Mice.
JAX Notes, Fall 2003; 491. JAX West Expansion
JAX Notes, January 1988; 432. Arthritis Models in the Mouse.
JAX Notes, July 1987; 430. BALB/cJ vs. BALB/cByJ.
JAX Notes, Spring 1990; 441. Imperforate Vagina and Mucometra in Mice.
JAX Notes, Spring 2003; 489. Malocclusion in the Laboratory Mouse.
JAX Notes, Summer 1992; 450. Myoepitheliomas in Inbred Laboratory Mice.
JAX Notes, Summer 2003; 490. Hydrocephalus in Laboratory Mice
JAX Notes, Winter 2002; 488. Colony Expansions Completed for JAX-82; Mice Strains C57BL/6J and BALB/cJ.
JAX Notes, Winter 2006; 504. JAX® Mice: the Gold Standard Just Got Better.
This mouse can be used to support research in many areas including:
Increased Tumor Incidence (Mammary Gland Tumors: late onset)
Diet-Induced Atherosclerosis (Relatively Resistant)
Behavioral and Learning Defects (high anxiety)
Neurodevelopmental Defects (callosal agenesis, incomplete penetrance)
Cancer Research (monoclonal antibodies, myeloma and hybridoma production)
Bentvelzen P; Daams JH; Hageman P; Calafat J. 1970. Genetic transmission of viruses that incite mammary tumor in mice. Proc Natl Acad Sci U S A 67(1):377-84. [PubMed: 4318784] [J:24803]Additional References
Heston WE; Vlahakis G. 1971. Mammary tumors, plaques, and hyperplastic alveolar nodules in various combinations of mouse inbred strains and the different lines of the mammary tumor virus. Int J Cancer 7(1):141-8. [PubMed: 4322934] [J:24674]
Paigen B; Ishida BY; Verstuyft J; Winters RB; Albee D. 1990. Atherosclerosis susceptibility differences among progenitors of recombinant inbred strains of mice. Arteriosclerosis 10(2):316-23. [PubMed: 2317166] [J:22615]
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|Standard Supply||Level 1. Readily Available.|
Males not available after seven weeks of age.|
Shipped at a specific age in weeks. Mice at a precise age in days, littermates and retired breeders are also available.
Strains that must be genotyped are not available until five to seven weeks of age.
Genomic DNA is available for this strain from the Mouse DNA Resource.
|Licensing||See General Terms and Conditions of Sale below|