Professor Sir James Underwood MD FRCPath

Professor Sir James Underwood

Joseph Hunter Professor and Dean of the Faculty of Medicine
Consultant Histopathologist to Sheffield Teaching Hospitals NHS Trust

Academic Unit of Pathology
E Floor
Medical School
University of Sheffield
Beech Hill Road
S10 2RX
United Kingdom

Telephone: +44 (0)114 271 2501
Facsimile: +44 (0)114 226 1464

Research Interests

Liver disease

  • Estimation of disease status and risk of progression in hepatitis C. Consulting histopathologist to Trent Hepatitis C Study Group.
  • Collaborating histopathologist in multidisciplinary studies and drug trials in autoimmune liver disease (primary biliary cirrhosis and autoimmune hepatitis).

Breast disease

  • Investigations of the role of steroid hormones and their receptors in determining the progression of preneoplastic and preinvasive ductal epithelial lesions.

Diagnostic Interests

  • Histopathology and cytopathology of breast, liver and gastrointestinal diseases.

Educational Activities


  • Lecturer on MSc in Pathological Sciences and in Human Nutrition.
  • Member of Course Management Teams for annual Short Courses on the Autopsy and on Diagnostic Histopathology.


  • Lecturer on MBChB and BDS courses.

Editorial & journal activities

  • Editorial Board member of Medical Law Review and Editorial Advisory Board member of Histopathology and of Cytopathology.
  • Co-editor, with Professor Massimo Pignatelli, of Recent Advances in Histopathology.
  • Editor of General and Systematic Pathology, Churchill Livingstone, 2004 (4th edition).

National & international activities

  • President, Royal College of Pathologists, 2002-2005
  • Vice-Chairman, Academy of Medical Royal Colleges

Recent papers & abstracts

Primary endometrioid adenocarcinoma of the large intestine arising in colorectal endometriosis. Petersen VC, Underwood JCE, Wells M, Shepherd NA. Histopathology 2002;40:171-6

Necropsy practice after the "organ retention scandal": requests, performance, and tissue retention. Burton JL, Underwood JCE. J Clin Pathol 2003;56:537-41

Mathematical modelling of comedo ductal carcinoma in situ of the breast. Franks SJ, Byrne HM, Mudhar HS, Underwood JCE, Lewis CE. Math Med Biol 2003;20:277–308

Alphastatin, a 24 amino acid fragment of human fibrinogen, is a potent new inhibitor of activated endothelial cells in vitro and in vivo. Staton CA, Brown NJ, Rodgers GR, Corke KP Tazzyman S, Underwood JCE, Lewis CE. Blood 2004;103:601-6

Modelling the early growth of ductal carcinoma in situ of the breast. Franks SJ, Byrne HM, King JR, Underwood JCE, Lewis CE. J Math Biol. 2003;47:424-52

Progression of hepatic fibrosis in patients with hepatitis C: a prospective repeat liver biopsy study. Ryder SD, Irving WL, Jones DA, Neal KR, Underwood JC; Trent Hepatitis C Study Group. Gut. 2004;53:451-5

Histopathology training in Europe: a lesson for other specialties? Ruiter DJ, Roald B, Underwood JCE, Prat J. Virchows Archives (in press)

Clearance of hepatitis C virus is not associated with SNPs in the IL–1, –6 or –10 genes. Minton EJ, Smillie D, Smith P, Shipley S, McKendrick M, Gleeson D, Underwood JCE, Cannings C, Wilson AG and the Trent Hepatitis C Study Group. Human Immunology (in press)

Western Bank, Sheffield S10 2TN, UK