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[Key Benefits of HA Supplementation | Basic Functions of Hyaluronic Acid] [HA in Synovial Joint Fluid | HA is a Key Component of Cartilage] [HA is in the Extracellular Matrix | Hyaluronic Acid in Skin] [Medical Treatment With HA | Nutritional Supplementation With HA] [Conclusion | References]
Key Benefits of Hyaluronic Acid Supplementation
Basic Functions of Hyaluronic AcidAs Hyaluronic Acid is present in every tissue of the body; hyaluronic acid’s importance cannot be underestimated. Retention of water is one of the most important biological functions of hyaluronic acid, 1 second only to providing nutrients and removing waste from cells that do not have a direct blood supply, such as cartilage cells. With a lower than adequate amount of hyaluronic acid, nutrients cannot be moved into these cells and waste cannot be eliminated from cells. Hyaluronic acid is sometimes abbreviated as HA. Hyaluronic acid is found in the synovial joint fluid, the vitreous humor of the eye, the cartilage, blood vessels, extracellular matrix, skin and the umbilical cord.2 Hyaluronic Acid is Found in Synovial Joint FluidOur joints (like the elbows and knees) are surrounded by a membrane called the synovial membrane, which forms a capsule around the ends of the bones. This membrane secretes a liquid called the synovial fluid. Basically, the synovial fluid is found in joint cavities. It has many functions, including serving as a lubricant, shock absorber and a nutrient carrier. The fluid protects the joints and bones. Cartilage is immersed in the synovial fluid and is a fibrous connective tissue. Cartilage is avascular, meaning it contains no blood vessels. This is why the synovial fluid is so important. Synovial fluid is the only way in which nutrients can be carried into the cartilage and waste can be removed. 2 Hyaluronic Acid is a Key Component of CartilageCartilage is a specialized form of connective tissue. Hyaline cartilage is the most predominant form of cartilage in the body. It lends strength and flexibility to the body. A key component of cartilage is hyaluronic acid. Cartilage is also avascular – with no blood vessels. Nutrients are brought by the synovial fluid, which is rich in hyaluronic acid to the cartilage, which is also hyaluronicacid rich. 2 Hyaluronic Acid is in the Extracellular MatrixHyaluronic Acid is found in the extracellular matrix (ECM). The ECM is composed of material (fibrous elements, including glycosamino-glycans) produced by the cells and excreted to the extracellular space with the tissues. All nutrients and metabolic waste are transported through the ECM. Hyaluronic acid is a major constituent of the ECM and serves as an essential structural element of the ECM. Hyaluronic acid locks moisture into the ECM and hyaluronic acid supports the structural integrity of the extracellular matrix.2,3 Hyaluronic Acid in the SkinIn the skin, the extracellular matrix is composed of hyaluronic acid and other sulfated GAGs, combined with collagen and elastin. Large amounts of water are held in the ECM. When elastin is not bathed in water, it becomes dry and brittle, thus the look of dry, brittle, wrinkled skin.1 Half-life is defined as the time required for one half of the total amount of a particular substance to be consumed, broken down, or depleted. The half-life of hyaluronic acid in the cartilage is 2-3 weeks. But the half-life of hyaluronic acid in the skin is less than 1 day! Hyaluronic acid is present in both the dermis and the epidermis. 50% of the body’s naturally produced hyaluronic acid that is found in the epidermis is metabolized and excreted in less than 24 hours. Like hyaluronic acid produced in the body, hyleronic acid taken as a nutritional supplement moisturizes from the dermis to the epidermis - from deeper layers of the skin to the outer layer. The extracellular matrix fills up the space between the skin cells. This makes the skin soft, smooth and elastic. But as we age, hyaluronic content in the skin changes due to two separate clinically proven factors.
Both changes leave the epidermis depleted in hyaluronic acid
resulting in thinning, aging, and decreased moisture in the skin. Medical Treatment with Hyaluronic AcidHyaluronic acid for use by humans has been derived from rooster combs. Rooster combs provide the purest form of hyaluronic acid available. Osteoarthritis
Treatment From the Leaflet “Treating Knee Osteoarthritis with Injections” published by the American Academy of Family Physicians: "Your doctor might inject an anesthetic agent. This is a medicine that makes your knee numb. It can stop the pain for a short time--maybe days or a few weeks. Another medicine, called a corticosteroid, can be injected along with the anesthetic. These medicines together might make your pain stay away longer. "In the past few years, a medicine called hyaluronic acid has been used for knee injections. Some hyaluronic acid is already in the fluid in your joints. In people with osteoarthritis, the hyaluronic acid gets thinner. When this happens, there isn't enough hyaluronic acid to protect the joint like it used to. Injections can put more hyaluronic acid into your knee joint to help protect it." Skin
Treatment Alternative
Treatments Nutritional Supplementation with Hyaluronic AcidHyaluronic acid extracted from rooster combs has too large a chemical size for absorption by the intestinal tract. When directly extracted from rooster combs, the molecular weight is 1.2 to 1.5 million Daltons (Da).2 For comparison, the average molecule weight of an amino acid is approximately 110 Da. But, wouldn’t you know it, Japanese scientists developed a proprietary enzyme-cleaving technique to lower the molecular weight of hyaluronic acid without altering its chemical nature. The final molecular weight of hyaluronic acid processed by the Injuv™ process is 5,000 Daltons. This allows hyaluronic acid to be taken orally as a nutritional supplement. Oral Hylauronic acid studies show benefits for most study participants when taken for a period of only 2 to 4 months. Patient reports indicate that continued use of hyaluronic acid sustain the benefits. Some patients are able to decrease the dose after the desired results are achieved. Hyaluronic acid side effects are rare and mild. Anyone allergic to chicken should exercise care taking hyaluronic acid. If mild stomach upset occurs when taken alone, take with or after a meal. Conclusion
References
Excerpts reprinted with exclusive permission from Source Naturals,
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