Welcome to the
Dog Genome Project!
The Dog Genome Project is a collaborative study involving scientists at the University of California, Berkeley, the University of Oregon, and the Fred Hutchinson Cancer Research Center. It is aimed at producing a map of all the chromosomes in dogs. Such a map can be used to locate the genes causing disease and those controlling morphology and behavior. Continued here.
Our Collaboration Includes:
- Cloning Simple Sequence Repeats which will act as signposts for the construction of the map. Tetramer Repeats at the FHCRC Dog Genome Group WWW server. These markers are available from Research Genetics.
- Localizing and ordering these markers on the dog chromosomes using linkage analysis and Fluorescent In Situ Hybridization (FISH).
- Generating Hybrid Cell Lines that have only one dog chromosome in them. For more information, see the FHCRC DGP page.
- Developing new techniques to aid in the faster identification of disease genes. One method currently being adapted for use in canines is the " Cleaved Amplified Polymorphic Sequences technique" (CAPS).
- Cloning very long stretches of dog DNA into manipulatable minichromosomes using Yeast Artificial Chromosomes (YACs).
- Using the Dog Codon Frequency Table to design PCR primers find the dog versions of already cloned human and mouse genes.
- There is a page available for you to get a quick look at how we map genes using DNA markers.
- For a more in depth description, check out the Primer on Molecular Genetics from the Department of Energy. (This is written about the Human Genome Project, but should help in understanding what the Dog Genome Project will be doing).
This site was originally created by Melissa DeMille with assistance from John Lovell. All questions relating to the Dog Genome Project should be directed to Jasper_Rine@ls.berkeley.edu .
