Synthesis of ester derivatives of salicylic acid and diflunisal
Let's look at some chemical structures:
One problem occurs with aspirin is that it has a destructive effect on the blood vessel walls and inhibit the synthesis of prostacyclin. To resolve this problem, we can use potential anti-platelet agents including the O-acyl esters which are synthesized from salicylic acid and diflunisal. Those agents work by acylation of cyclooxygenase and have a higher extraction than aspirin. That makes them yield a greater selectivity in their effect on platelet inhibition relative to prostacyclin inhibition on vessel walls.The actual reaction is shown on the top.
For reference, please click on http://www.citeulike.org/user/hongan1985/article/246557
2 Comments:
1) please don't delete the comments I make even if you make the necessary changes. It will prevent me from having to make the same comments over and over since students make similar mistakes.
2) shorten you links so they don't go wider than the blog.
By Jean-Claude Bradley, at 1:45 PM
Full Marks. In the future make your structures a bit bigger. For example, instead of drawing the reaction left to right, you could have done it top to bottom without risking being too wide for the blog.
By Jean-Claude Bradley, at 5:12 AM
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