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(c) 1998-2003 DigiBio S.A.   

J. Allergy Clin. Immunol. 99:S175, 1997

J. Aïssa, P. Jurgens, W. Hsueh and J. Benveniste. Digital Biology Laboratory (DBL), 32 rue des Carnets, 92140 Clamart, France and NorthWestern University Medical School, Chicago, IL 60614, USA.

Ligands so dilute that no original molecule remained still retained biological activity which could be abolished by magnetic fields [1-3], suggesting the electromagnetic (EM) nature of the molecular signal. This was later confirmed by the electronic transfer to water (W) of molecular activity, either directly or after computer storage [4-7]. Here, we report its transfer via the telephone network. Ovalbumin (Ova) or W as control, was recorded (1 sec, 16 bits, 22 kHz) into a diskette in Chicago using a transducer and computer equipped with sound-card. Coded files were transferred to diskettes in DBL's computer as "attached documents" via Internet e-mail. After digital amplification they were replayed for 20 min via a transducer to 15 ml W-containing plastic tubes. Exposed W (dOva, dW), was then perfused to isolated hearts from Ova-immunized guinea-pigs. The heart operator was always blind while technical incidents revealed the identity of 4/19 files to the computer operator. Coronary flow variations were (%, mean+SEM, nb of measures): naive W (negative control), 4.9+0.3, 41; dW, 4.4+0.3, 58; dOva, 24.0+1.4, 30, p= 4.5 e -17 vs dW; Ova (0.1 µM, positive control), 28.9+3.7,19, ns vs dOva. The hitherto neglected physical nature of the molecular signal emerges: EM radiation under 22 kHz that can be digitized, transferred long distances and replayed to W, which then mimicks the activity of the source-molecule. This implies novel strategies in chemistry, biology and medicine. [1] Davenas et al., Nature. 1988, 333:816; [2] Benveniste et al., CR Acad Sci Paris. 1991, 312:461; [3] Benveniste et al., FASEB J. 1992, 6:A1610; [4,5] Aissa et al., FASEB J. 1993, 150:A146 & 1995, 9:A425; [6] Thomas et al., FASEB J. 1996, [7] Benveniste et al., FASEB J. 1996, 10:A1479. Supported by Association Science Innovante.