Bianconi was born at Tregolo, Northern Italy, 24th September, 1786.

At the age of 16 a young Bianconi was considered to be friendly with a neighbours daughter who was already betrothed in her childhood to one of nobility.

To avoid scandal Bianconi's father sent his only son away. He arrived in Dublin in 1802. On 6th July 1815, he started to run a One-Horse Cart between Clonmel and Cahir which extended to Thurles, Limerick and Waterford. By the end of 1825 he had secured a number of mail contracts and his vehicles, locally called BIANS, were covering 1,170 miles a day. In 1857, regardless of competition from the railways, they were running 4,244 miles daily in 22 counties.

His headquarters were in Clonmel in Bagwell St., now known as Parnell St. Here Bianconi installed his trusted friend and assistant Daniel Hearn, who later converted the house overlooking the stable yard, to Hearn's Hotel. In 1828 after the birth of his eldest child, he moved to the former Charter School which he named Silverspring (on the Waterford road). He was twice Mayor of Clonmel. While living there Bianconi was a regular worshipper in the Friary Church. Charles Bianconi died at Longford House on 22nd September 1875, at the age of 89. He buried at Boherlahan, Co. Tipperary, in the graveyard of the Church which he himself had built.