Beta-Lactamase Inhibitors

Beta-lactamase inhibitors are proteins designed to inhibit or destroy the effectiveness of beta-lactamase enzymes. Inhibitors generally have little antimicrobial properties themselves and so are combined with a beta-lactam antibiotic. These inhibitors (clavulanic acid, sulbactam, tazobactam) function by binding to the beta-lactamase enzymes more "efficiently" than the actual beta-lactam antibiotic itself. This combination allows the antibiotic "do its job" without being degraded by the beta-lactamase enzymes. Several antibiotic/beta-lactamase inhibitor combinations exist on the market. However, only Augmentin (amoxicillin and clavulanate) is available for use in pediatric AOM. Click here for more information on Augmentin.

Send comments to Terry Leiker
Department of Nursing
College of Health and Life Sciences
Fort Hays State University
Revised October 2000