Social Deficits, Social withdrawal

Repetitive, perseverative, stereotyped behaviors; OCD-typical behaviors

Depression, mood swings, flat affect; impaired facial recognition

Schizoid tendencies; hallucinations; delirium

Irritability, aggressive behaviors, temper tantrums

Suicidal Behaviors

Sleep difficulties/ disturbances

Chronic fatigue (CFS); weakness, malaise

Anorexia; symptoms reflecting eating disorders, loss of appetite/weight

Anxiety; nervous tendencies

Attentional problems (ADHD), lacks eye contact, impaired visual fixation

Speech disorders

Loss of speech, developmental problems with language

Speech comprehension deficits

Dysarthria; articulation problems; slurred speech, unintelligible speech

Mental retardation, borderline intelligence

Uneven performance on IQ scores, low IQ scores

Poor concentration, attention deficits (ADHD), response inhibition

Poor memory (short term, verbal, and auditory)

Difficulties understanding abstract ideas; difficulty carrying out complex commands

Dementia; pre-senile and senile dementia

Stupor

Impaired reaction time; lower performance on timed tests

Abnormal Sensations in the mouth and extremities

Hearing loss, difficulty hearing

Abnormal touch sensations; diminished touch sensations, aversion to touch

Blurred vision; sensitivity to light

Choreiform movements, myoclonal jerks, unusual postures

Difficulty walking, swallowing, talking

Flapping, circling, rocking, toe walking

Problems with intentional movements or imitation

Abnormal gait/posture; incoordination, loss of balance; problems sitting, lying, crawling, and walking

Decreased locomotor activity

Convulsions; seizure

Neurofibrillary tangles

Neuritis, retrobulbar neuritis; neuropathy

Encephalopathy

Cerebrovascular disease

Alterations in nerve conduction velocity

Alterations in the spinal chord

Accumulates in CNS structures

Abnormal EEGs

Autonomic disturbances

Peripheral neuropathy

Alterations in peripheral nerves

Loss of feeling/ numbness in the extremities; paresthesia

Nausea, vomiting, diarrhea; loss of appetite

Abdominal pain, stomach cramps; burning of the throat and mouth

Esophagitis; gastroenteritis; colitis

Cancers (colon, pancreatic, stomach, or rectal)

Hepatotoxicity; Liver dysfunction, damage

Cirrhosis of the liver; hepatitis

Kidney disease ; kidney failure

Renal toxicity; tubular proteinosis

Kidney Damage, histological alterations

Blood vessel damage

Anemia; decreased red blood cell count

Hypertension; increased heart rate (tachycardia)

Peripheral vascular disease; cardiovascular disease; vascular collapse

Pulmonary Fibrosis

Pulmonary edema

Pneumonia, laryngitis, pharyngitis, bronchitis

Restrictive airway disorders, asthmatic conditions, pneumoconisis

Respiratory tract cancers

Nasal ulcers, perforation of the nasal septum

Increased incidences of asthma, autoimmune-like symptoms, allergies & inhibition of lymphocytes, T-cells, monocytes

Immunosuppression

Decreased white blood cell count

Genital abnormalities

Disturbances in menstrual cycle; menstrual pains

Birth defects; premature births; Spontaneous abortion

Reproductive dysfunction

Hypotonia or hypertonia; decreased muscular strength

Rashes, contact dermatitis, eczema, itchy/irritating skin

Muscle pain; headache; acrodynia; colic

Alopecia (hair loss)