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LIVER SUPPORT
FORMULA
Double Blind Studies
have shown significant decreases in degenerative liver damage
in patients with chronic liver disease
(CIRRHOSIS of the LIVER) while using Extreme Health's
Liver Support Formula in as few as 30-90 days.
Liver Support Formula (artichoke-liver-detox):
This is an extremely effective product for detoxifying the
liver, normalizing liver metabolism and preventing further
liver damage
Recommended for those who:
•Consume Alcohol
•Consume Tobacco Products
•Have been taking Medications/Drugs
•Are exposed to Environmental Toxins or Chemicals or
Second Hand Smoke
•Have a history of Liver or Gall Bladder Problems
The accumulation of chemicals in our body from
the water that we drink and bathe in, the air that we breathe,
and the food that we eat have been shown to weaken the immune
system and contribute to the development degenerative diseases
like cancer.
Liver
Support System Ingredient Rationale
A proprietary blend of artichoke (Cynara Floridanum) and sarsaparilla
(Smilax Aristolochiaefolia) that contains the following naturally
occurring bioflavonoids and polyphenols: silymarin, quercetin,
catechin, hesperidin, rutin, cynarin, and chlorogenic acid.
Bioflavonoids are a class of water-soluble plant pigments
(colors) that have anti-inflammatory, antihistaminic and anti-viral
properties. Health professionals formulated The Liver Support
System specifically for detoxifying the liver and gall bladder
and supporting each of their functions.
Included Bioflavonoids
1. Silymarin
Numerous clinical studies have shown silymarin to be among
the most powerful natural agents available for the prevention
and treatment of liver damage caused by exposure to human-made
chemicals including alcohol induced liver degeneration and
cirrhosis.
2. Quercetin
Quercetin is a bioflavonoid with antioxidant effects. It is
used for the prevention of atherosclerosis, hypercholesterolemia
(excess cholesterol in the blood), and coronary heart disease.
It can inhibit carcinogenesis and reduce capillary fragility.
Quercetin is used extensively in the treatment of athletic
injuries because it relieves pain and bruising and acts synergistically
with Vitamin C to protect and preserve the structure of capillaries.
It also promotes circulation, lowers cholesterol levels and
treats and prevents cataracts. Quercetin fights cancer, diabetes,
capillary fragility, and arthritis; stabilizes membranes;
protects against heart disease and allergies; normalizes blood
pressure; helps lowers cholesterol; and slows aging.
3. Catechin
Catechin, another naturally occurring flavonoid, is similar
in effect to silymarin. Catechin is a powerful anti-oxidant
that helps prevent free radical oxidative damage to cells.
It also helps in the treatment and prevention of alcohol and
chemical-induced liver disease or damage. Catechin is also
valuable for its ability to neutralize intestinal toxins and
assist in the stabilization of cell membranes.
4. Hesperidin
Hesperidin has been shown to be useful in clinical trials
as an analgesic and anti-inflammatory.
5. Rutin
An antioxidant bioflavonoid, free radical scavenger, and an
iron-chelator. It is used as a vascular protector for reducing
capillary fragility, permeability, and bleeding; as a treatment
for varicose vein symptoms; and as preventive for stroke (the
sudden rupture or clotting/blockage of a blood vessel to the
brain). Some studies show that Rutin offers protection from
damage induced by asbestos, the cytotoxic effects of oxidized
low-density lipoproteins (LDL), and gastric injury from ethanol.
It also offers some protection against DNA damage caused by
hepatocarcinogens. Rutin is used extensively in the treatment
of athletic injuries because it relieves pain and bruises
and acts synergistically with Vitamin C to protect and preserve
the structure of capillaries. It also promotes circulation,
lowers cholesterol levels, and treats and prevents cataracts.
6. Cynarin
Cynarin assists in the detoxification of the liver and gall
bladder. It also supports the function of these two important
organs while and assists in their regeneration following damage.
Cynarin stimulates the clearance of bile from the liver, preventing
congestion in the liver and thus diminishing the chances of
liver damage.
7. Sarsaparilla
Sarsaparilla has been used in the treatment of the following
conditions: gout, arthritis, digestive disorders, skin diseases,
and cancer. Sarsaparilla contains saponins, which are steroid-like
agents that bind with toxins in the digestive tract. Historically,
sarsaparilla has been used as a 'blood purifier' and a general
tonic for diseases associated with increased endotoxin levels,
including arthritis, intestinal ulcerative conditions, eczema,
and psoriasis.
The tonic effect of sarsaparilla is the result of its ability
to stimulate the removal of accumulated waste products from
the cells, blood, and lymph. These actions tend to increase
the health of the entire body and increase vitality, thereby
increasing energy and endurance.
8. Chlorogenic Acid (16%)
Chlorogenic Acid is a naturally occurring, water soluble,
phenolic acid that is a potent anti-oxidant, carcinogenic
inhibitor and protector against lipid peroxidation and free
radical mediated cell injury.
9. Silymarin (16%)
Numerous clinical studies have shown silymarin to be among
the most powerful natural agents available for the prevention
and treatment of liver damage caused by exposure to human-made
chemicals including alcohol induced liver degeneration and
cirrhosis.
10. Quercetin
Quercetin is a bioflavonoid with antioxidant effects. It is
used for the prevention of atherosclerosis, hypercholesterolemia
(excess cholesterol in the blood), and coronary heart disease.
It can inhibit carcinogenesis and reduce capillary fragility.
Quercetin is used extensively in the treatment of athletic
injuries because it relieves pain and bruising and acts synergistically
with Vitamin C to protect and preserve the structure of capillaries.
It also promotes circulation, lowers cholesterol levels and
treats and prevents cataracts. Quercetin fights cancer, diabetes,
capillary fragility, and arthritis; stabilizes membranes;
protects against heart disease and allergies; normalizes blood
pressure; helps lowers cholesterol; and slows aging.
11. Catechin
Catechin, another naturally occurring flavonoid, is similar
in effect to silymarin. Catechin is a powerful anti-oxidant
that helps prevent free radical oxidative damage to cells.
It also helps in the treatment and prevention of alcohol and
chemical-induced liver disease or damage. Catechin is also
valuable for its ability to neutralize intestinal toxins and
assist in the stabilization of cell membranes.
12. Hesperidin
Hesperidin has been shown to be useful in clinical trials
as an analgesic and anti-inflammatory.
13. Rutin
An antioxidant bioflavonoid, free radical scavenger, and an
iron-chelator. It is used as a vascular protector for reducing
capillary fragility, permeability, and bleeding; as a treatment
for varicose vein symptoms; and as preventive for stroke (the
sudden rupture or clotting/blockage of a blood vessel to the
brain). Some studies show that Rutin offers protection from
damage induced by asbestos, the cytotoxic effects of oxidized
low-density lipoproteins (LDL), and gastric injury from ethanol.
It also offers some protection against DNA damage caused by
hepatocarcinogens. Rutin is used extensively in the treatment
of athletic injuries because it relieves pain and bruises
and acts synergistically with Vitamin C to protect and preserve
the structure of capillaries. It also promotes circulation,
lowers cholesterol levels, and treats and prevents cataracts.
14. Cynarin
Cynarin assists in the detoxification of the liver and gall
bladder. It also supports the function of these two important
organs while and assists in their regeneration following damage.
Cynarin stimulates the clearance of bile from the liver, preventing
congestion in the liver and thus diminishing the chances of
liver damage.
15. Sarsaparilla
Sarsaparilla has been used in the treatment of the following
conditions: gout, arthritis, digestive disorders, skin diseases,
and cancer. Sarsaparilla contains saponins, which are steroid-like
agents that bind with toxins in the digestive tract. Historically,
sarsaparilla has been used as a 'blood purifier' and a general
tonic for diseases associated with increased endotoxin levels,
including arthritis, intestinal ulcerative conditions, eczema,
and psoriasis.
The tonic effect of sarsaparilla is the result of its ability
to stimulate the removal of accumulated waste products from
the cells, blood, and lymph. These actions tend to increase
the health of the entire body and increase vitality, thereby
increasing energy and endurance.
16. Chlorogenic Acid (16%)
Chlorogenic Acid is a naturally occurring, water soluble,
phenolic acid that is a potent anti-oxidant, carcinogenic
inhibitor and protector against lipid peroxidation and free
radical mediated cell injury.
DOUBLE BLIND STUDY
2nd Double Blind Study
COMPARATIVE STUDY BETWEEN A COMPLEX OF FLAVONOIDS AND POLYPHENOLS
CREATED FROM EXTRACTS OF ARTICHOKE AND SARSAPRILLA AND A PLACEBO
IN ALCOHOL RELATED LIVER DISEASE
DECEMBER 12, 1998
In a previous study, completed over two years ago in this
same hospital, an extract of artichoke (Cynara Floridanum)
and sarsaparilla (Smilax Aristolochiaefolia) was evaluated
in addressing the symptoms related to alcoholic liver disease.
This study was accomplished over a fifteen-day period with
exceptional results. Because of these results noted over a
very short period of time, the hospital researchers were anxious
to set up the same study over a longer period (30 days). Please
refer to the July 3, 1996, study for descriptions of symptoms
and study parameters. Results of this study are as follows:
ASCITES
A 72.38% reduction of the accumulation of serous abdominal
fluid was noted in the treated group. The placebo saw a 6.35%
increase in abdominal fluid.
ENCEPHALOPATHY
A 66.08% reduction of symptoms related to encephalopathy was
noted in the treated group. The placebo group saw a 12.24%
increase in these symptoms.
HEPATOMEGALY
The treated group experienced a 93.33% reduction in enlarged
livers. In the placebo group their livers continued to enlarge
by another 7.14%.
SPLENOMEGALY
An 88.40% reduction in spleen enlargement was noted with the
treated group. The placebo group worsened by 11.54%.
WEAKNESS
The treated group noted a 73.64% increase in strength. There
was a decrease in muscle strength by 7.41% in the placebo
group.
PERIPHERAL EDEMA
Edema in the extremities of the treated patients decreased
by 48.21%. There was no change in the placebo group.
HEMORRHAGES
The treated group noted a 100% decrease in capillary hemorrhaging
in the skin, gums, and nasal membranes. The placebo group
saw an increase of 28.57% in hemorrhaging.
ANOREXIA
Loss of appetite decreased in the treated group by 76.98%.
The placebo group noted a decrease of 3.70%.
ABDOMINAL WALL VEINS
The treated group experienced a 60.62% decrease in tortuous
veins in the abdomen related to ascites. The placebo group
saw a 3.33% decrease.
PALMAR ERYTHEMA
The treated group noted a 26.67% decrease in red and swollen
palms. In the placebo group there was no change.
TELANGIECTASIA
A 60.00% reduction in vascular lesions was noted in the treated
group. A 3.33% reduction was seen in the placebo group.
TOTAL BILIRUBIN
The treated group noted a reduction of total bilirubin by
38.95%. The placebo group increased by 5.68%.
ALKALINE PHOSPHATASE
The treated group obtained 25.91% reduction in alkaline phosphates.
There was an 11.69% increase in the placebo group.
SERUM GLUTAMIC OXALCETIC TRANSAMINASE (SGOT)
The treated group noted a decrease of 23.83% in SGOT levels.
The placebo group experienced a worsening of 11.71%.
PROTHROMBIN TIME
A 42.00% reduction in clotting time was noted with the treated
group. An increase in clotting time was noted in the placebo
group of 6.60%.
SERUM ALBUMIN
An increase of 37.27% in serum albumin was noted in the treated
group. There was a decrease in the placebo group of 1.95%.
GAMMA GLUTAMYL TRANSPEPTIDASE (GGT)
The treated group noted a reduction of 23.79% in GGT. The
placebo group experienced an increase of 9.92%.
DR. CHARLES COCHRAN
1st
Double Blind Study
INTERPRETATION OF RESULTS OBTAINED IN A DOUBLE BLIND TEST
MADE IN THE GENERAL HOSPITAL MEXICO WITH THE PRODUCT LIVER
SUPPORT ON PATIENTS HAVING CHRONIC ALCOHOLIC HEPATIC DISEASE.
In order to analyze carefully the results of this study, it
is necessary to know the importance of the two clinical and
laboratory parameters intervening in the calculations of Orrego
and Maddrey Indexes. We will compare the results of the parameters,
the placebo control and the Liver Support groups on both indexes.
The results are presented as percentages of recovery and are
obtained from the data obtained from each group of 30 patients;
we will get an average of those results at the beginning and
at the end of the study. Both averages will give us a final
recovery compared to the initial values. This way we may demonstrate
the effectiveness of Liver Support
DEFINTIONS AND RESULTS OF PARAMETERS
ASCITES- Effusion and accumulation of serous fluid in the
abdominal cavity. The experimental group (Liver Support) experienced
a 28.8% reduction of ascites while the placebo group experienced
no change.
ENCEPHALOPATHY- a DEGENERATIVE DISEASE OF THE BRAIN. Hepatic
encephalopathy- a condition usually occurring secondarily
to advanced disease of the liver. It is marked by disturbances
of consciousness that may progress to deep coma (hepatic coma),
psychiatric changes of varying degree,
flapping tremor and fetor hepaticas. Also called portal-systemic
encephalopathy. Patients on Liver Support experienced a 34.55%
reduction of hepatic encephalopathy. The placebo group experienced
a 5.5% reduction.
SPLENOMEGALIA- Enlargement of the spleen. An 18.18% reduction
was observed in the Liver Support group and a 55% reduction
was observed in the placebo group.
WEAKNESS- Lacking physical strength or vigor marked by asthenia,
atony, cardiasthena, enervation, fatigue and lassitude. The
Liver Support group experienced an 83.45% decrease in the
incidence of weakness while the placebo group reported no
change.
PERIPHERAL EDEMA- A condition in which the body tissues contain
an excess amount of fluid. The Liver Support Group experienced
an 11.10% reduction in peripheral edema while the placebo
group had a 0.69% reduction.
HEMORRHAGES- Bleeding. This was one of the most important
benefits observed in the Liver Support group. The Liver Support
group had an 89.41% reduction in hemorrhages while the placebo
had a 31% reduction.
ANOREXIA- Loss of appetite. Seen in depression, malaise, commencement
of fevers and illness, also in disorders of the alimentary
tract, especially of the stomach, and as a result of alcoholic
excess and drug addiction. Anorexia was diminished by 86.07%
in the Liver Support group. There was no change in the placebo
group.
TOTAL BILIRUBIN LEVEL - The predominant pigment of human bile.
Total serum bilirubin may be increased in cirrhosis of the
liver and acute viral hepatitis. The Liver Support group obtained
25.11% reduction in bilirubin, whereas the placebo group had
a 7.2% increase.
OGT - (Oxalacetic Glutamic Transaminase). It is distributed
all over body tissue, especially in the heart and liver. Less
amounts are found in the spleen, pancreas, kidneys, lungs
and brain. Any lesion of a tissue leads to the secretion of
this enzyme to the blood stream. The activity of OGT is risen
under hepatic necrosis, cirrhosis of the liver or hepatic
metastasis. In those patients who received Liver Support this
level diminished 22.56% in only 15 days of treatment and in
the placebo group it diminished 8.51%.
PROTHROMBINE TIME - A test of clotting time made by determining
the time for clotting to occur after thromboplastin and calcium
are added to decalcified plasma. There was 30.82% reduction
in prothrombin time for Liver Support patients, whereas the
placebo group's time increased 1.25%. This is very important
data, because it means that Liver Support helps the healing
of wounds faster.
SERUM ALBUMIN - One of a group of simple proteins widely distributed
in tissues. Albumin is a constituent of blood. Low levels
of albumin in blood plasma are associated with a pathologic
condition of the liver. The Liver Support group experienced
an increase of 8.85% of total albumin levels while the placebo
group experienced a 5.35% increase.
AUTISM AND
DETOXIFICATION
Might autistic children be the proverbial "canaries in the
coal mine" whose nervous systems are more susceptible to the
impact of toxic heavy metals in the environment, incurring
neurological damage even at low exposure levels? One recent
study found that in one group of 18 autistic children, 16
had blood levels of toxic heavy metals and chemicals exceeding
adult maximum tolerance. This build-up of toxins may not arise
simply from excessive exposure, but from a marked inability
to process and eliminate toxins from the body. Indeed, when
the children were assessed using a biochemical analysis to
gauge the body's ability to detoxify substances, researchers
found that every child showed out-of-range results suggesting
a defect in this two-phase detoxification process. Researchers
explained that such a mechanism could lead to a backup of
toxic heavy metals and chemical toxins with increased free
radical activity in the body. Since the blood-brain barrier
of children is still not fully developed, these toxic and
oxidized molecules could penetrate into regions of the brain
and damage neutrons, receptors, synapses, enzymes, and cell
mitochondria, and also set off auto immune reactions triggering
further damage.
According to other studies, autistic children
may have problems metabolizing and detoxifying certain compounds
due to an impaired biochemical process called sulfation.
Sulfation plays an important role in the second phase of the
detoxification process. Impaired sulfation could make autistic
children more vulnerable to multiple heavy metal and chemical
sensitivities. It may also help explain an exacerbation of
behavioral problems after children eat foods containing phenol,
tyramine, and phenyl compounds, which are normally neutralized
through the sulfation process.
Much concern has been raised over the link between
exposure to heavy metal toxins and neurological brain damage
associated with learning and behavior disorders in children.
Indeed, research shows that exposure to heavy metals such
as lead, mercury and antimony, can impair brain development
at very early ages, even at low doses previously deemed "harmless."
Children are particularly susceptible to the deleterious effects
of heavy metal exposure for several reasons. First, their
developing nervous systems are more sensitive. Second, their
bodies absorb toxins more rapidly, yet clear them from the
system more slowly than from adults. Finally, a child's blood-brain
barrier, the natural protective mechanism which blocks harmful
substances from entering and damaging the brain, is not yet
fully formed.
Many professionals working in the field of autism
have expressed concern that some autistic children were exposed
to potentially damaging levels of ethylmercury, which is a
preservative used in certain vaccinations. Clinical neurobehavioral
symptoms of mercury poisoning seem to parallel closely many
common symptoms of autism. In response to pressure from the
FDA, the U.S. Public Health Service, and other regulatory
health agencies, vaccine manufacturers have since worked to
reduce or eliminate the use of ethylmercury as a preservative
in many vaccines.
In addition, several studies have associated
high lead levels in children with autism. Elevated levels
of lead in hair - signify long-term toxic exposure to this
heavy metal - were correlated with increased behavior abnormalities
and learning disorders in children. Based on clinicians' observations,
antimony, a potential toxin found in some fire retardant materials,
is also a possible cause for concern.
Nutritional balance and healthy metabolism are
also very important. Dr. Lynn Wecker and his colleagues at
Louisiana State Medical Centre observe that trace element
imbalances in the human body can disrupt neurotransmitter
function and produce marked changes in behavior; many of which
are consistent with symptoms of autism. For this reason Dr.
Wecker and his team evaluated trace element concentrations
in the hair of autistic children. They found clear
deficiencies of calcium, copper, zinc, and chromium that were
so striking that they allowed them to discriminate between
autistic children and healthy controls with a high degree
of accuracy using just test results. Deficiencies
of mineral nutrients can make a child more susceptible to
heavy metal absorption. Magnesium deficiencies, associated
with attention-deficit disorder and hyperactivity, may also
be clinically significant in autism. Extreme Health's Liver
Support Formula radically improves liver metabolism and
promotes the detoxification of the liver and the body.
REFERENCES:
Accardo P, Whitman B, Caul J, Rolfe U. Autism
and plumbism. A possible association. Clinical Pediatric 1988;
27(1):41-4. Alberti A, Pirrone P, Elia M, Waring RH, Romano
C. Sulphation deficit in "low-functioning" autistic
children: a pilot study. Biol Psychiatry 1999;46(3):420-4.
Cohen DJ, Johnson WT, Caparulo BK. Pica and elevated blood
lead level in autistic and atypical children. Am J Dis Child
1976;130(1):47-48. Edelson SB, Cantor DS. Autism: Xenobiotic
influences. Toxicology and industrial health 1998;14(4):553-563.
Emory E, Pattillo D, Archibald E, Byroh M, Sung F. Neurobehavioral
effects of low-level lead exposure in human neonates. Am J
Obstet Gynecol 1999;181:S2-S11. Eufemia P, Celli M, Finocchiaro
R, Pacifico L, Viozzi L, Zaccagnini M, Cardi E, Giardini O.
Abnormal intestinal permeability in children with autism.
Acta Paediatr 1996:85(9):1076-9.
Goodwin MS, Cowen MA, Goodwin TC. Malabsorption and cerebral
dysfunction: a multivariate and comparative study of autistic
children. J Autism Child Schizophr 1971; 1:48-62. Halsey NA.
Limiting infant exposure to thimerosal in vaccines and other
sources of mercury. JAMA. 199 Nov 10;282(18):1763-6. Horvath
K, Papadimitriou JC, Rabsztyn A, Drachenberg C, Tildon JT.
Gastrointestinal abnormalities in children with autistic disorder.
J. Pediatr 1999; 135:559-63. Kozielec T, Starobrat-Hermelin
B. Assessment of magnesium levels in children with attention
deficit hyperactivity disorder (ADHD). Magnes Res; 1997 Jun;
10(2):143-8. Lanphear BP, Dietrich K, Auinger P, Cox C. Subclinical
lead toxicity in U.S. children and adolescents [abstract#894].
APS/SPR Joint Meeting; 2000 May 12-16; Boston MA. McFadden
SA. Phenotypic variation in xenobiotic metabolism and adverse
environmental response: focus on sulfur-dependent detoxification
pathways. Toxicology 1996;111 (1-3):43-65. Shannon M, Graef
Jw. Lead intoxication in children with pervasive developmental
disorders. J Toxicol Clin Toxicol 1996;34(2):177-81. Tuthill
RW. Hair lead levels related to children's classroom attention-deficit
behavior. Arch Enciron Health 1996;(3):214-220. Wecker L,
Miller SB, Cochran SR, Dugger DL, Johnson WD. Trace element
concentrations in hair from autistic children. J Ment Defic
Res 1985; 15-22. Wilson MA, Johnston MV, Goldstein GW, Blue
ME. Neonatal lead exposure impairs development of rodent barrel
field cortex. PNAS 2000; 97(10):5540-5545.
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