The American Cancer Society estimates that in the United States about 1,530 new cases of penile cancer will be diagnosed and an estimated 280 men will die of penile cancer in 2006. Penile cancer occurs in about 1 man in 100,000 in the United States.
Penile cancer is very rare in North America and Europe. It accounts for about 0.2% of cancers in men and 0.1% of cancer deaths in men in the United States. However, penile cancer is much more common in some parts of Africa and South America, where it accounts for up to 10% of cancers in men.