David F. Dinges, Ph.D.
Director, Unit for Experimental Psychiatry
David F. Dinges, Ph.D., is Professor of Psychology in Psychiatry, Chief of the Division of Sleep and Chronobiology in the Department of Psychiatry, and Associate Director of the Center for Sleep and Respiratory Neurobiology in the University of Pennsylvania School of Medicine.
He is also a member of Penn's Institute for Neurological Sciences, the Psychology Graduate Group, the Biological Basis of Behavior faculty, and an Adjunct Professor in the School of Biomedical Engineering, Science and Health Systems, at Drexel University. Dr. Dinges earned his M.S. and Ph.D. degrees in Experimental Physiological Psychology from Saint Louis University. He also trained at the Central Institute for the Deaf, Washington University School of Medicine in St. Louis, at George Washington University Hospital in Washington, D.C., and at the Institute for Experimental Psychiatry at Pennsylvania Hospital and the University of Pennsylvania.
His laboratory is dedicated to scientific discovery of the physiological, cognitive and functional changes resulting from sleep loss and behavioral stressors in humans, and to evaluating behavioral, pharmacological and technological countermeasures to these effects. His research has primarily focused on the manner in which neurobiology regulating sleep homeostasis and circadian rhythmicity control cognitive, affective, behavioral, endocrine and immunological processes in humans. His research has involved extensive laboratory, simulator and field studies on the consequences of sleep loss and circadian misalignment from both lifestyle and medical disorders; effects of sleep disorders; recovery potential of naps; nature of sleep inertia; impact of cumulative sleep debt; differential vulnerability to the neurobehavioral effects of sleep loss; and development of technologies for monitoring human neurobehavioral capability, such as the widely used the Psychomotor Vigilance Test (PVT). He has over 230 publications and his scientific work has been funded for 30 consecutive years by numerous Federal Agencies, including NIH, NASA, DOD, DOT, and DHS, as well as private foundations.
His research on the physiological and behavioral effects of sleep deprivation, and ways to mitigate these effects, has been extensively used to inform both Federal and private regulatory policies. He has also advised many Federal and private organizations concerned with issues of sleep in relation to work hours, health and safety, including the U.S. Congress; National Institutes of Health; National Transportation Safety Board; Department of Justice; Department of Transportation; Surgeon General's Office of the Air Force; American Trucking Association; Accreditation Council of General Medical Education and the Association of American Medical Colleges.
Dr. Dinges has served as President of the Sleep Research Society and on the Board of Directors of the American Academy of Sleep Medicine and the National Sleep Foundation. He currently serves as President of the World Federation of Sleep Research and Sleep Medicine Societies. He has been the recipient of numerous awards for teaching and research, including the 2002 Senator Mark O. Hatfield Public Policy Award and the 2004 William C. Dement Academic Achievement from the American Academy of Sleep Medicine; as well as a 2004 Decade of Behavior Research Award from the American Psychological Association. He is currently Editor-in-Chief of SLEEP, the leading scientific journal on sleep research and sleep medicine.
Chee, M.W.L., Chuah, L.Y.M., Venkatraman, V., Chan, W.Y., Philip, P., Dinges, D.F.: Functional imaging of working memory following normal sleep and after 24 and 35 h of sleep deprivation: Correlations of fronto-parietal activation with performance. NeuroImage (2006).
Dinges, D.F., Arora, S., Darwish, M., Niebler, G.E.: Pharmacodynamic effects on alertness of single doses of armodafinil in healthy subjects during a nocturnal period of acute sleep loss. Current Medical Research and Opinions, 22(1): 159-167, 2006.
Wang, J., Wetmore, G.S., Rao, H., Furlan, P.M., Korczykowski, M.. Dinges, D.F., Detre, J.A.: The stressed brain — perfusion fMRI reveals cerebral blood flow pattern under psychological stress. Proceedings of the National Academy of Sciences 102(49): 17804-17809, 2005.
Durmer, J.S. and Dinges, D.F.: Neurocognitive consequences of sleep deprivation. Seminars in Neurology, 25(1): 117-129, 2005.
Drummond, S.P.A., Bischoff-Grethe, A., Dinges, D.F., Ayalon, L., Mednick, S.C., Meloy, M.J.: The neural basis of the psychomotor vigilance task. Sleep 28(9):1059-1068, 2005.
Dinges, D.F., Rider, R.L., Dorrian, J., McGlinchey, E.L., Rogers, N.L., Cizman, Z., Goldenstein, S.K., Vogler, C., Venkataraman, S., Metaxas, D.N.: Optical computer recognition of facial expressions associated with stress induced by performance demands. Aviation, Space & Environmental Medicine 76(6): B172-182, 2005.
Czeisler , C.A. , Walsh, J.K., Roth, T., Hughes, R.J., Wright, K.P., Kingsbury, L., Arora, S., Schwartz, J.R.L., Niebler, G., Dinges, D.F.: Modafinil for excessive sleepiness associated with shift work sleep disorder. New England Journal of Medicine, 353:476-486, 2005.
O’Reardon, J.P., Ringel, B.L., Dinges, D.F., Allison, K.C., Martino, N.S., Stunkard, A.J.: Circadian eating and sleeping patterns in the night eating syndrome. Obesity Research 12(11): 1789-1796, 2004.
Rogers, A.E., Wei-Ting Hwang, Scott, L.D., Aiken, L.H., Dinges, D.F.: The working hours of hospital staff nurses and patient safety. Health Affairs 23(4): 202-212, 2004.
Mallis, M.M., Mejdal, S., Nguyen, T.T., Dinges, D.F.: Summary of the key features of seven biomathematical models of human fatigue and performance. Aviation, Space & Environmental Medicine 75 (3):A4-A14, 2004.
Dinges, D.F.: Critical research issues in development of biomathematical models of fatigue and performance. Aviation, Space and Environmental Medicine 75 (3):A181-A191, 2004.
Szuba, M.P., Kloss, J.D., Dinges, D.F. (Eds.): Insomnia: Principles and Management. Cambridge University Press, New York, NY, 2003
Meier-Ewert, H.K., Ridker, P.M., Rifai, N., Regan, M.M., Price,
N.J., Dinges, D.F., Mullington, J.M. Effect
of sleep loss on C-reactive protein, an inflammatory marker of cardiovascular
risk. Journal of the American College of Cardiology 43:
Van Dongen, H.P.A., Baynard, M.D., Maislin, G., Dinges, D.F. Systematic interindividual differences in neurobehavioral impairment from sleep
loss: Evidence of trait-like differential vulnerability. Sleep
27: 423-433, 2004.
Dinges, D.F., Weaver, T.E. Effects
of modafinil on sustained attention performance and quality of life
in OSA patients with residual sleepiness while being treated with
nCPAP. Sleep Medicine 4: 393-402, 2003.
Mullington, J.M., Chan, J.L., Van Dongen, H.P.A., Szuba, M.P., Samaras,
J., Price, N.J., Meier-Ewert, H.K., Dinges, D.F., Mantzoros, C.S. Sleep
loss reduces diurnal rhythm amplitude of leptin in healthy men. Journal
of Neuroendocrinology 15: 851-854, 2003.
Rogers, N.L., Dorrian, J., Dinges, D.F. Sleep,
waking and neurobehavioral performance. Frontiers in Bioscience
8: s1056-1067, 2003.
Van Dongen, H.P.A., Dinges, D.F. Investigating
the interaction between the homeostatic and circadian processes of
sleep-wake regulation for the prediction of waking neurobehavioral
performance. Journal of Sleep Research 12: 181-187, 2003.
Van Dongen, H.P.A., Maislin, G., Mullington, J.M., Dinges, D.F. The
cumulative cost of additional wakefulness: Dose-response effects
on neurobehavioral functions and sleep physiology from chronic sleep
restriction and total sleep deprivation. Sleep 26: 117-126, 2003.
Van Dongen, H.P.A., Rogers, N.L., Dinges, D.F. Sleep
Debt: Theoretical and empirical issues. Sleep and Biological
Rhythms 1: 5-13, 2003.
Weaver, T.E., Maislin, G., Dinges, D.F., Younger, J., Cantor, C., McCloskey,
S., Pack, A.I. Self-efficacy
in sleep apnea: Instrumental development and patient perceptions of
obstructive sleep apnea risk, treatment benefit, and volition to use
continuous positive airway pressure. Sleep 26: 727-732, 2003.
Walsh, J.W., Dement, W.C., Dinges, D.F.: Sleep Medicine, Public Policy and Public Health. In: Kryger, M.H., Roth, T., Dement, W.C. (Eds.) Principles and Practice of Sleep Medicine (4th edition), W.B. Saunders, Philadelphia, PA, pp. 648-656, 2005.
Van Dongen, H.P.A., Dinges, D.F.: Circadian Rhythm in Sleepiness, Alertness and Performance. In: Kryger, M.H., Roth, T., Dement, W.C. (Eds.) Principles and Practice of Sleep Medicine (4th edition), W.B. Saunders, Philadelphia, PA, pp. 435-443, 2005.
Mallis, M.M., Dinges, D.F.: Monitoring Alertness and Drowsiness On-Line, Real-Time. In: Stanton, N., Hedge, A., Brookhuis , K., Salas, E., Hendrick, H. (Eds.) The Handbook of Human Factors and Ergonomics Methods, CRC Press, New York, NY. pp. 25-1 - 25-6, 2005
Dorrian, J., Rogers, N.L., Dinges, D.F.: Psychomotor vigilance performance: A neurocognitive assay sensitive to sleep loss. In: Kushida, C. (Ed.), Sleep Deprivation: Clinical Issues, Pharmacology and Sleep Loss Effects. Marcel Dekker, Inc., New York, NY, pp. 39-70, 2005.
Dinges, D.F., Baynard, M., Rogers, N.L.: Chronic Sleep Restriction. In: Kryger, M.H., Roth, T., Dement, W.C. (Eds.) Principles and Practice of Sleep Medicine (4th edition), W.B. Saunders, Philadelphia, PA, pp. 67-76, 2005.
Bonnet, MH, Balkin, TJ, Dinges, DF, Roehrs, T, Rogers, NL, Wesensten, NJ: The Use of Stimulants to Modify Performance During Sleep Loss: A Review by the Sleep Deprivation and Stimulant Task Force of the American Academy of Sleep Medicine. Sleep, 28(9):1163-1187, 2005
Van Dongen, H.P.A., Kerkhof, G.A., Dinges, D.F.: Human circadian rhythms. In: Sehgal, A. (Eds.) Molecular Biology of Circadian Rhythms, John Wiley and Sons, Inc, pp. 255-269, 2004.
Ballas, C., Evans, D.L., Dinges, D.F.: Amphetamine, Methylphenidate and Modafinil. In: Schatzberg, A.F. and Nemeroff, C.B. (Eds.) Textbook of Psychopharmacology (3rd edition), American Psychiatric Publishing, Washington, DC, pp. 671-684, 2004