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List of publications by Dr. Suresh I.S. Rattan

Key words: Aging, ageing, anti-aging, gerontogene, vitagene, stress response, heat shock, hormesis, protein modification, kinetin, zeatin, cytokinins, gerontology, biogerontology, longevity,

Danish keywords: aldring, alderdom, antirynker, ældning

Research Papers and Review Articles
 

2008

176. Berge, U., Kristensen, P. and Rattan, S.I.S. Hormetic modulation of differentiation of normal human epidermal keratinocytes undergoing replicative senescence in vitro. Experimental Gerontology, (in press) doi: 10.1016/j.exger.2007.12.009

175. Rattan, S.I.S. Increased molecular damage and heterogeneity as the basis of aging. Biochemical Journal (in press)

174. Rattan, S.I.S. Hormesis in aging. Ageing Research Reviews, 7: 63-78, 2008, (doi: 10.1016/j.arr.2007.03.002)

2007

173. Barciszewska, M.Z., Barciszewska, A.M. and Rattan, S.I.S. TLC-based detection of methylated cytosine: application to aging epigenetics. Biogerontology, 8, 673-678, 2007. (doi: 10.1007/s10522-007-9109-3)

172. Rattan, S.I.S., Sejersen, H, Fernandes, R.A. and Luo, W. Stress mediated hormetic modulation of wound healing and angiogenesis in human cells  Annals of the New York Academy of Sciences, 1119: 112-121, 2007.

171.  Rattan, S.I.S. The science of healthy aging: genes, milieu, and chance.  Annals of the New York Academy of Sciences, 1114: 1-10, 2007.

170. Singh, R., Kølvraa, S. and Rattan, S.I.S. (2007) Genetics of longevity with emphasis on the relevance of HSP70 as candidate genes. Frontiers in Bioscience, 12: 4504-4513, 2007.

169. Berge, U., Behrens, J. and Rattan, S.I.S  Sugar-induced premature aging and altered differentiation in human epidermal keratinocytes Annals of the New York Academy of Sciences, 1100: 524-529, 2007.

168. Sejersen, H and Rattan, S.I.S  Glyoxal-induced premature senescence in human fibroblasts. Annals of the New York Academy of Sciences, 1100: 518-523, 2007.

167. Rattan, S.I.S. and Ali, R.E. Hormetic prevention of molecular damage during cellular aging of human skin fibroblasts and keratinocytes. Annals of the New York Academy of Sciences, 1100: 424-430, 2007.

166. Rattan, S.I.S. (2007) Homeostasis, homeodynamics, and aging. In: Encyclopedia of Gerontology, (2nd edition; edited by J. Birren), pp. 696-699 Elsevier Inc. UK.
 

2006

164. Bhattacharya, K. and Rattan, S.I.S. Dietary fats and age-related diseases. In: Prevention and Treatment of Age-related Diseases (Editors: S.I.S. Rattan and M. Kassem), pp. 335-356; Springer, Dordrecht, The Netherlands., 2006.

164. Rattan, S.I.S. Biological causes of aging and age-related diseases. In: Prevention and Treatment of Age-related Diseases (Editors: S.I.S. Rattan and M. Kassem), pp. 1-13; Springer, Dordrecht, The Netherlands, 2006.

163. Rattan, S.I.S. Theories of biological aging: genes, proteins and free radicals. Free Radical Research, 40: 1230-1238, 2006.

 

162. Singh, R., Kølvraa, S., Bross, P., Jensen, U.B., Gregersen, N., Tan, Q.,  Knudsen, C., and Rattan, S.I.S. Reduced heat shock response in human mononuclear cells during aging and its association with polymorphisms in HSP70 genes. Cell Stress and Chaperones, 11: 208-215, 2006.

 

161. Deocaris, C.C., Shrestha, B.G., Kraft, D.C., Yamasaki, K., Kaul, S.C., Taira, K., Rattan, S.I.S. and Wadhwa, R. Geroprotection by glycerol: insights to its mechanisms and clinical potentials.  Annals of the New York Academy of Sciences, 1067: 488-492, 2006.

160. Gonzalez-Dosal, R.,Sørensen, M.D., Clark, B.F.C., Rattan, S.I.S. and Kristensen, P. Phage displayed antibodies  for the detection of glycated proteasome in aging cells. Annals of the New York Academy of Sciences, 1067: 474-478, 2006.

159. Nørgaard, R., Kassem, M., and Rattan, S.I.S. Heat shock-induced enhancement of osteoblastic differentiation of hTERT-immortalized mesenchymal stem cells. Annals of the New York Academy of Sciences, 1067: 443-447, 2006.

158. Kraft, D.C., Deocaris, C.C. Wadhwah, R and Rattan, S.I.S. Preincubation with the proteasome inhibitor MG-132 enhances proteasome activity via the Nrf2 transcription factor in aging human skin fibroblasts. Annals of the New York Academy of Sciences, 1067: 422-426, 2006.

157Ali, R.E. and Rattan, S.I.S. Curcumin’s  biphasic  hormetic response on proteasome activity and heat shock protein synthesis in human keratinocytes. Annals of the New York Academy of Sciences 1067: 394-399, 2006.

156. Nielsen, E.R., Eskildsen-Helmond, Y.E.G. and Rattan, S.I.S. MAP kinases and heat shock-induced hormesis in human fibroblasts during serial passaging in vitro. Annals of the New York Academy of Sciences 1067: 343-348, 2006.

155. Berge, U., Kristensen, P. and Rattan, S.I.S. Kinetin-induced differentiation of normal human keratinocytes undergoing aging in vitro. Annals of the New York Academy of Sciences 1067: 332-336, 2006.

154. Singh, R., Kølvraa, S., Bross, P., Christensen, K., Gregersen, N., Tan, Q., Jensen, U.B., Eiberg, H and Rattan, S.I.S. Heat shock protein 70 genes and human longevity: a view from Denmark. Annals of the New York Academy of Sciences 1067: 301-308, 2006.

153.  Kraft, D.C., Deocaris, C.C. and Rattan, S.I.S. Proteasomal oscillation during mild heat shock in aging human skin fibroblasts. Annals of the New York Academy of Sciences 1067: 224-227, 2006.

152. Rattan, S.I.S. Principles of ageing and practice of anti-ageing therapies. Asian Journal of Experimental Sciences, 20: 17-26, 2006.

 

2005

151. Rattan, S.I.S.  Hormetic modulation of aging and longevity by mild heat stress. Dose Response, 3, 535-546, 2005.

150. Olshansky, S.J. and Rattan, S.I.S. What determines longevity: metabolic rate or stability? Discovery Medicine, 5, 359-362, 2005.

149. Olshansky, S.J. and Rattan, S.I.S. At the heart of aging: is it metabolic rate or stability? Biogerontology, 6: 291-295; 2005.

148. Rattan, S.I.S. and Clark, B.F.C. Understanding and modulating ageing. IUBMB Life, 57: 297-304, 2005.

147. Rattan, S.I.S. Anti-ageing strategies: prevention or therapy? EMBO Reports, 6; S25-S29, 2005.

146. Rattan, S.I.S. and Sodagam, L. Gerontomodulatory and youth-preserving effects of zeatin on human skin fibroblasts undergoing aging in vitro. Rejuvenation Research, 8: 46-57, 2005.

 

2004

145. Rattan, S.I.S.  Aging intervention, prevention and therapy through hormesis. Journals of Gerontology Biological Sciences, 59A: 705-709, 2004.

144. Rattan, S.I.S., Gonzalez-Dosal, R., Nielsen, E.R., Kraft, D.C., Weibel, J. and Kahns, S.  Slowing down aging from within: mechanistic aspects of anti-aging hormetic effects of mild heat stress on human cells. Acta Biochimica Polonica, 51: 481-492, 2004.

143. Rattan, S.I.S. Hormetic mechanisms of anti-aging and rejuvenating effects of repeated mild heat stress on human fibroblasts in vitro. Rejuvenation Research, 7, 40-48, 2004.

142. Singh R, Kølvraa, S., Bross, P., Gregersen, N., Nexø, B.A., Frederiksen, H., Christensen, K. and Rattan, S.I.S. Association between low self-rated health and heterozygosity for -110A>C polymorphism in the promoter region of HSP70-1 in aged Danish twins. Biogerontology, 5, 169-176, 2004.

141. Rattan, S.I.S. Mechanisms of hormesis through mild heat stress on human cells. Annals of the New York Academy of Sciences, 1019: 554-558, 2004.

140. Rattan, S.I.S. Aging, anti-aging, and hormesis. Mechanisms of Ageing and Development, 125,285-289, 2004.

139. Beedholm, R., Clark, B.F.C. and Rattan, S.I.S. Mild heat stress stimulates 20S proteasome and its 11S activator in human fibroblasts undergoing aging in vitro. Cell Stress and Chaperones, 9, 49-57, 2004.

138. Rattan, S.I.S., Eskildsen-Helmond, Y. and Beedholm, R.  Molecular mechanisms of anti-aging hormetic effects of mild heat stress on human cells. Non-Linearity in Biology, Toxicology and Medicine, 2: 1-12, 2004.

 

2003

137. Rattan, S.I.S. Transcriptional and translational dysregulation during aging. In: Aging at the Molecular Level. (edt: T. von Zglinicki), pp. 179-191, Kluwer Academic Publishers, The Netherlands, 2003.

136. Rattan, S.I.S. Aging outside the body: usefulness of the Hayflick system. In: Aging of Cells Inside and Outside the Body. (edt: S. Kaul and R. Wadhwa), pp. 1-8,Kluwer Academic Publishers, The Netherlands, 2003.

135. Minois, N. and Rattan, S.I.S. Hormesis in aging and longevity. In: Modulating Aging and Longevity (edt: S.I.S. Rattan), pp. 127-137, Kluwer Academic Publishers, The Netherlands, 2003.

134. Hercus, M., Loeschcke, V. and Rattan, S.I.S. Extension of longevity of Drosophila by repeated mild heat stress exposures, Biogerontology, 4, 149-156, 2003.

133. Rattan, S.I.S. Biology of aging and possibilities of gerontomodulation. Proceedings of the Indian National Science Academy, B69, 157-164, 2003.
 

 

2002

132. Rattan, S.I.S. A global view of the causes of ageing. An interview with Robin Holliday. Biogerontology, 3, 317-324, 2002.

Co-endorser of the "Position Statement on Human Aging", published as the weblink in the June issue of Scientific American (http://www.sciam.com/explorations/2002/051302aging/ )
 

131. Fonager, J., Beedholm, R., Clark, B.F.C. and  Rattan, S.I.S.  Mild stress-induced stimulation of heat shock protein synthesis and improved functional ability of human fibroblasts undergoing aging in vitro. Experimental Gerontology, 37: 1223-1228.

130. Simonsen, J.L., Rosada, C., Serak, N., Justesen, J., Stenderup, K., Rattan, S.I.S., Jensen, T.G. & Kassem, M.  Telomerase expression extends the proliferative life-span and maintains the osteogenic potential of human bone marrow stromal cells. Nature Biotechnology, 20, 592-596, 2002.

129. Verbeke, P., Deries, M., Clark, B.F.C. & Rattan, S.I.S. Hormetic action of mild heat stress decreases the inducibility of protein oxidation and glycoxidation in human fiborblasts. Biogerontology,3, 117-120, 2002.

 128. Rattan, S.I.S. N6-furfuryladenine (kinetin) as a potential anti-aging molecule. Journal of Anti-Aging Medicine, 5, 113-116, 2002.
 

2001

127. Verbeke, P., Clark, B.F.C. & Rattan, S.I.S.  Reduced levels of oxidized and glycoxidized proteins in human fibroblasts exposed to repeated mild heat shock during serial passaging in vitro. Free Radicals in Biology and Medicine, 31, 1593-1602, 2001.

126. Rattan, S.I.S. & Siboska, G. Kinetin: et potentielt anti-aldringsmolekyle. Dansk Kemi, 82 (#11), 45-47, 2001. (in Danish)

125. Beedholm, R. & Rattan, S.I.S. Proteasomet. Aktuel Naturvidenskab, 3 (#4), 4-6, 2001. (in Danish)

 124.  Rattan, S.I.S. "I no longer believe in programmed aging", an interview with Vincent Cristofalo. Biogerontology, 2, 283-290, 2001.

123. Rattan, S.I.S. Hormesis in biogerontology. Critical Reviews in Toxicology, 31, 663-664, 2001.

122. Rattan, S.I.S. Ungdommens Kilde. Aktuel Naturvidenskab, 3 (#3), 25-27, 2001. (in Danish)

121.  Verbeke, P., Fonager, J., Clark, B.F.C. & Rattan, S.I.S.  Heat shock response and ageing: mechanisms and applications. Cell Biology International, 25, 845-857, 2001.

120. Rattan, S.I.S. Applying hormesis in aging research and therapy. Human and Experimental Toxicology, 20, 281-285, 2001.   first published in: BELLE Newsletter, 9, (3) 2-5, 2001. (with 10 expert commentaries, and my response on pp. 28-29).

119. Stenderup, K., Justesen, J., Eriksen, E.F., Rattan, S.I.S. & Kassem, M. Number and proliferative capacity of osteogenic stem cells are maintained during aging and in patients with osteoporosis. Journal of Bone and Mineral Research, 16, 1120-1129, 2001.

118. Rattan, S.I.S. From vitagenes to gerontogenes and the other way around: research strategies. In: Current Concepts in Experimental Gerontology (Eds: C. Bertoni-Freddari and H. Niedermüller), pp. 15-22; Facultas Wien, 2001.

117. Kveiborg, M., Rattan, S.I.S., Clark, B.F.C., Eriksen, E.F. & Kassem M. Treatment with 1,25-dihydroxyvitamin D3 reduces impairment of human osteoblast functions during cellular aging in culture. Journal of Cellular Physiology, 186, 298-306, 2001.
 

2000

116. Barciszweski, J., Siboska, G., Rattan, S.I.S. & Clark, B.F.C. Occurrence, biosynthesis and properties of kinetin (N6-furfuryladenine). Plant Growth Regulation, 32, 257-265, 2000.

115. Barciszweski, J., Siboska, G., Clark, B.F.C & Rattan, S.I.S.  Cytokinin formation by oxidative metabolism. Journal of Plant Physiology, 157, 587-588, 2000.

114. Kveiborg, M., Flyvbjerg, A., Rattan, S.I.S. & Kassem M. Changes in the insulin-like growth factor-system may contribute to in vitro age-related impaired osteoblast functions.  Experimental Gerontology, 35, 1061-1074, 2000.

113. Verbeke, P., Clark, B.F.C. & Rattan, S.I.S. Modulating cellular aging in vitro:hormetic effects of repeated mild heat stress on protein oxidation and glycation. Experimental Gerontology, 35, 787-794, 2000.

112. Verbeke, P., Siboska, G.E., Clark, B.F.C. & Rattan, S.I.S. Kinetin inhibits protein oxidation and glycoxidation in vitro. Biochemical and Biophysical Research Communications, 276, 1265-1270, 2000.

111.  Rattan, S.I.S. "Just a fellow who did his job...", an interview with Leonard Hayflick. Biogerontology, 1, 79-87, 2000.

110. Rattan, S.I.S. & Kveiborg, M. Alderdomsbiologi - det naeste skridt. Aktuel Naturvidenskab, 2 (#4), 4-6, 2000. (in Danish)

109. Christiansen, M., Stevnsner, T., Bohr, V.A., Clark, B.F.C. and Rattan, S.I.S.    Gene-specific DNA repair of pyrimidine dimers does not decline during cellular aging in vitro. Experimental Cell Research, 256, 308-314, 2000.
 

108. Christiansen, M., Kveiborg, M., Kassem, M., Clark, B.F.C. and Rattan, S.I.S.    CBFA1 and topoisomerase I mRNA levels decline during cellular aging of human trabecular osteoblasts. Journals of Gerontology: Biological Sciences, 55A, B194-B200, 2000.
 

107.  Rattan, S.I.S.  Biogerontology: the next step. Annals of the New York Academy of Sciences, 908, 282-290, 2000.
 

106.  Rattan, S.I.S. Gerontogenes, ageing, and hormesis. Indian Journal of Experimental Biology, 38, 1-5, 2000.
 
 

1999
 
 

105.  Olsen, A., Siboska, G.E., Clark, B.F.C. and Rattan, S.I.S.  N6-furfuryladenine, kinetin, protects against Fenton reaction-mediated oxidative damage to DNA. Biochemical and Biophysical Research Communications, 265: 499-502, 1999.
 

104. Kveiborg, M., Kassem, M., Langdahl, B., Eriksen, E.F., Clark, B.F.C. and Rattan, S.I.S. Telomere shortening during aging of human osteoblasts in vitro and leucocytes in vivo: lack of excessive telomere loss in osteoporotic
patients. Mechanisms of Ageing and Development, 106: 261-271, 1999.
 

103. Barciszewski, J., Barciszewska, M., Siboska, G., Rattan, S.I.S. and Clark, B.F.C. Some unusual nucleic acid bases are products of hydroxyl radical oxidation of DNA and RNA. Molecular Biology Reports, 26, 31-38, 1999.
 

102. Barciszewski, J., Rattan, S.I.S., Siboska, G. and Clark, B.F.C. Kinetin - 45 years on. Plant Science, 148, 37-45, 1999.
 

101. Rattan, S.I.S. Ageing genes: gerontogenes. Encyclopaedia of Life Sciences, (Macmillan Press, UK), Article # 3059; 1999
 

100. Rattan, S.I.S. Cellular senescence in vitro. Encyclopaedia of Life Sciences, (Macmillan Press, UK), Article # 2567; 1999.
 

99. Rattan, S.I.S. and Clark, B.F.C. Protein synthesis, post-translational modifications and aging. Alfred Benzon Symposium, 44,320-331, 1999.
 
 

1998
 

97. Rattan, S.I.S. Repeated mild heat shock delays ageing in cultured human skin fibroblasts. Biochemistry and Molecular Biology International, 45, 753-759, 1998.
 

96. Gonos, E.S., Derventzi, A., Kveiborg, M., Agiostratidou, G., Kassem, M., Clark, B.F.C., Jat, P.S. and Rattan, S.I.S. Cloning and identification of genes that associate with mammalian replicative senescence. Experimental Cell
Research, 240, 66-74, 1998.
 

95. Rattan, S.I.S. Is gene therapy for aging possible? Indian Journal of Experimental Biology, 36, 233-236, 1998.
 

94. Rattan, S.I.S.Molecular, cellular and genetic determinants of aging. Aging: Clinical and Experimental Research, 9, 430-432.
 

93. Rattan, S.I.S.The nature of gerontogenes and vitagenes. Antiaging effects of repeated heat shock on human fibroblasts. Annals of the New York Academy of Sciences, 854, 54-60, 1998.
 
 

1997
 

92. Sharma, S.P., Kaur, J. and Rattan, S.I.S.Increased longevity of kinetin-fed Zaprionus fruitflies is accompanied by their reduced fecundity and enhanced catalase activity. Biochemistry and Molecular Biology International, 41, 869-875, 1997.
 

91. Barciszewski, J., Siboska, G.E., Pedersen, B.O., Clark, B.F.C. and Rattan, S.I.S. Furfural, a precursor of the cytokinin hormone kinetin, and base propenals are formed by hydroxy radical damage of DNA. Biochemical and
Biophysical Research Communications, 238, 317-319, 1997.
 

90. Barciszewski, J., Siboska, G.E., Pedersen, B.O., Clark, B.F.C. and Rattan, S.I.S. A mechanism for the in vivo formation of kinetin as a secondary oxidative damage product in DNA. FEBS Letters, 414, 457-460, 1997.
 

89. Kassem, M., Ankersen, L., Eriksen, E.F., Clark, B.F.C. and Rattan, S.I.S. Demonstration of cellular aging and senescence in serially passaged long term cultures of human trabecular osteoblasts. Osteoporosis International, 7,
514-524, 1997.
 

88. Rattan, S.I.S. Gene therapy for ageing: mission impossible? Human Reproduction and Genetic Ethics, 3, 27-29, 1997.
 

87. Rattan, S.I.S. and Christiansen, M.Genterapi mod aldring: muligt eller ej? Ugeskrift for Læger, 159, 6381-6383, 1997. (in Danish)
 

86. Rattan, S.I.S. Genes for aging: gerontogenes.In: Molecular Biology of Development and Aging. (ed.: M.S. Kanungo), pp. 97-102, New Age Int. Pbl., New Delhi, India, 1997.
 
 

1996
 
 

85. Riis, B. and Rattan, S.I.S.The antibiotic fusidic acid inhibits ADP-ribosylation of protein elongation factor-2 in human cells. Medical Science Research, 24, 221-222, 1996.
 

84. Norsgaard, H., Rattan, S.I.S. and Clark, B.F.C. Distinction between differentiation and senescence and the absence of increased apoptosis in human keratinocytes undergoing cellular aging in vitro. Experimental Gerontology, 31, 563-570, 1996.
 

83. Barciszewski, J., Siboska, G.E., Pedersen, B.O., Clark, B.F.C. and Rattan, S.I.S. Evidence for the presence of kinetin in DNA and cell extracts. FEBS Letters, 393, 197-200, 1996.
 

82. Rattan, S.I.S. Cellular and molecular determinants of ageing. Indian Journal of Experimental Biology, 34, 1-6, 1996.
 

81. Rattan, S.I.S. and Kveiborg, M. Aldring i reagensglas: hvilken relevans? Gerontologi og Samfund, 12, 15-16,1996. (in Danish)
 

80. Rattan, S.I.S. Synthesis, modifications and turnover of proteins during cellular aging. Experimental Gerontology, 31, 33-47, 1996.
 

79. Rattan, S.I.S. Cellular ageing in vitro as the basis of understanding ageing in vivo. Facts and Research in Gerontology, 5, 7-17, 1996.
 

78. Rattan, S.I.S. and Clark, B.F.C. Intracellular protein synthesis, modifications and aging. Biochemical Society Transactions, 24, 1043-1049, 1996.
 

77. Derventzi, A., Rattan, S.I.S. and Gonos, E.S.Molecular links between cellular mortality and immortality. Anticancer Research, 16, 2901-2910, 1996.
 

76. Derventzi, A., Gonos, E.S. and Rattan, S.I.S.Ageing and cancer - a struggle of tendencies.In: Molecular Gerontology - Research Status and Strategies. (eds.: S.I.S. Rattan and O. Toussaint), pp. 15-23, Plenum Press, New York, USA, 1996.
 

75. Andersen, L.B., Lund, A., Kveiborg, M., Clark, B.F.C. and Rattan, S.I.S. From genes to functional gene products during ageing.In: Molecular Gerontology - Research Status and Strategies. (eds.: S.I.S. Rattan and O. Toussaint), pp.53-73, Plenum Press, New York, USA, 1996.
 

74. Toussaint, O. and Rattan, S.I.S. From molecular gerontology to healthy old age.In: Molecular Gerontology - Research Status and Strategies. (eds.: S.I.S. Rattan and O. Toussaint), pp. 201-209, Plenum Press, New York, USA,
1996.
 
 

1995
 

73. Riis, B., Rattan, S.I.S., Palmquist, K., Clark, B.F.C. and Nygård, O. Dephosphorylation of the phosphorylated elongation factor-2 in the livers of calorie-restricted and freely-fed rats during ageing. Biochemistry and Molecular Biology International, 35, 855-859, 1995.
 

72. Barciszewski, J., Barciszewska, M.Z., Rattan, S.I.S. and Clark, B.F.C.The structure and properties of 8-hydroxydeoxyguanosine - novel biomarker in aging and carcinogenesis studies. Polish Journal of Chemistry, 69, 841-851, 1995.
 

71. Levels of oxidative DNA damage product 8-hydroxy-2’-deoxyguanosine in human serum increase with age. Medical Science Research, 23, 469-470, 1995.
 

70. Sharma, S.P., Kaur, P. and Rattan, S.I.S.Plant growth hormone kinetin delays ageing, prolongs the lifespan and slows down development of the fruitfly Zaprionus paravittiger.Biochemical and Biophysical Research
Communications, 216, 1067-1071, 1995.
 

69. Rattan, S.I.S.Gerontogenes: real or virtual? FASEB J. 9, 284-286, 1995.
 

68. Rattan, S.I.S. Cellular and molecular basis of aging.In: Hormones and Aging (eds: P.S. Timiras, W.B. Quay & A.Vernadakis), pp. 267-290, CRC Press, Boca Raton, USA, 1995.
 

67. Rattan, S.I.S.Translation and post-translational modifications during aging.In: Molecular Basis of Aging (ed: A.Macieira-Coelho), pp. 389-420, CRC Press, Boca Raton, USA, 1995.
 
 

66. Rattan, S.I.S.Protein synthesis and regulation in eukaryotes.In: Principles of Medical Biology , vol. 4, Cell Chemistry and Physiology (eds: E.E. Bittar & N. Bittar), pp. 247-263, JAI Press Inc., USA, 1995.
 

65. Rattan, S.I.S. Ageing ? a biological perspective. Molecular Aspects of Medicine, 16, 439-508, 1995.
 

64. Rattan, S.I.S.Genes for ageing: gerontogenes.In: Proceedings of the EU Conference onThe Human Genome in Europe: Scientific, Ethical & Social Aspects. pp 32-36, Académie Royale de Médecine de Belgique, Brussels, 1995.
 
 

1994
 

63. Ankersen, L., Kassem, M., Ostergaard, L.H., Eriksen, E.E., Clark, B.F.C. and Rattan, S.I.S.Aging of human trabecular osteoblasts in culture. Archives of Gerontology and Geriatrics, suppl. 4, 5-12, 1994.
 

62. Norsgaard, H., Glenting, M., Kristensen, P. Clark, B.F.C. and Rattan, S.I.S.Aging, differentiation and apoptosis in human epidermal keratinocytes in culture. Archives of Gerontology and Geriatrics, suppl. 4, 185-196, 1994.
 

61. Svendsen, L., Rattan, S.I.S. and Clark, B.F.C.Testing garlic for possible anti-ageing effects on long-term growth characteristics, morphology and macromolecular synthesis of human fibroblasts in culture. Journal of
Ethnopharmacology, 43, 125-133, 1994.
 

60. Rattan, S.I.S. and Clark, B.F.C. Kinetin delays the onset of ageing characteristics in human fibroblasts. Biochemical and Biophysical Research Communications, 201, 665-672, 1994.
 

59. Rattan, S.I.S. and Stacey, G.N. The uses of diploid cell strains in research in aging.In: Cell and Tissue Culture: Laboratory Procedures (eds: J.B. Griffiths, A. Doyle & D.G. Newell), Part 6D, pp. 2.1-2.12, John Wiley, UK, 1994.
 
 

1993
 

58. Barciszewski, J., Rattan, S.I.S., Siboska, G.E., Otzen, D.E. and Clark, B.F.C.Reduction in the amount of
8-hydroxy-2´-deoxyguanosine in the DNA of SV40-transformed human fibroblasts as compared with normal cells in
culture. FEBS Letters, 318, 186-188, 1993.
 

57. Derventzi, A., Rattan. S.I.S. and Clark, B.F.C.Phorbol ester PMA stimulates protein synthesis and increases the levels of active elongation factors EF-1a and EF-2 in ageing human fibroblasts. Mechanisms of Ageing and
Development, 69, 193-205, 1993.
 

56. Riis, B., Rattan, S.I.S., Palmquist, K., Nilsson, A., Nygård, O. and Clark, B.F.C. Elongation factor 2-specific calcium and calmodulin dependent protein kinase III activity in rat livers varies with age and calorie restriction.
Biochemical and Biophysical Research Communications, 192, 1210-1216, 1993.
 

55. Johansen, L.B and Rattan, S.I.S.Protein synthesis and aging. Reviews in Clinical Gerontology, 3, 3-12, 1993.
 

54. Rattan, S.I.S. and Ankersen, L. Hvad er gerontogener? Gerontologi og Samfund, 9, 24-25, 1993. (in Danish)
 
 

1992
 

53. Derventzi, A., Rattan, S.I.S. and Clark, B.F.C.Phorbol ester-induced reorganization of the cytoskeleton in human fibroblasts during ageing in vitro. Biochemical Biophysical Research Communications, 182, 1423-1428, 1992.
 

52. Derventzi, A., Rattan. S.I.S. and Clark, B.F.C. Senescent human fibroblasts are more sensitive to the effects of a
phorbol ester on macromolecular synthesis and growth characteristics. Biochemistry International, 27, 903-911, 1992.
 

51. Barciszewski, J., Otzen, D., Rattan, S.I.S. and Clark, B.F.C. Specific incorportation of kinetin into eukaryotic and
prokaryotic transfer ribonucleic acid molecules. Biochemistry International, 28, 805-811, 1992.
 

50. Rattan, S.I.S. Regulation of protein synthesis during ageing. European Journal of Gerontology, 1, 128-136, 1992.
 

49. Rattan, S.I.S., Derventzi, A. and Clark, B.F.C.Protein synthesis, post-translational modifications and aging.
Annals of the New York Academy of Sciences, 663, 48-62, 1992.
 

48. Rattan, S.I.S. and Riis, B. Why we grow old.In: Realm of Differentiation (ed. M. Habibulla), pp 87-93,Neelkanth
Publishers, New Delhi, India, 1992.
 
 

1991

47. Rattan, S.I.S., Ward, W.F., Glenting, M., Svendsen, L., Riis, B. and Clark, B.F.C. Dietary calorie restriction does
not affect the levels of protein elongation factors in rat livers during ageing. Mechanisms of Ageing and Development,
58, 85-91, 1991.

46. Rattan, S.I.S. Aging and disease: proteins as the molecular link. Perspectives in Biology and Medicine, 34, 526-533,
1991.
 

45. Rattan, S.I.S. and Derventzi, A. Altered cellular responsiveness during ageing. BioEssays, 13, 601-606, 1991.
 

44. Rattan, S.I.S.Protein synthesis and the components of protein synthetic machinery. Mutation Research, 256,
115-125, 1991.
 

43. Derventzi, A. and Rattan, S.I.S.  Homeostatic imbalance during cellular ageing: altered responsiveness. Mutation
Research, 256, 190-202, 1991.
 

42. Rattan, S.I.S. and Derventzi, A. Gene expression during ageing: protein synthesis and post-translational
modifications. Topics in Aging Research in Europe, 16,133-142, 1991.
 
 

1990

41. Riis, B., Rattan, S.I.S., Derventzi, A. and Clark, B.F.C. Reduced levels of ADP-ribosylatable elongation factor-2 in
aged and SV40-transformed human cells. FEBS Letters, 266, 45-47, 1990.

40. Rattan, S.I.S. and Riis, B.Er vores livetid programmeret? Gerontologi og Samfund, 6, 6-8, 1990. (in Danish)
 

39. Riis, B., Rattan, S.I.S., Clark, B.F.C. and Merrick, W.C.  Eukaryotic protein elongation factors. Trends in
Biochemical Sciences (TIBS), 15, 420-424, 1990.
 

38. Rattan, S.I.S. and Kristensen, O. Continuous gene expression in vitro: the Spirin system. Trends in Biotechnology,
8, 275-276, 1990.
 
 

1989

37. Riis, B., Rattan, S.I.S., Cavallius, J, & Clark, B.F.C. ADP-ribosylatable content of elongation factor-2 changes
during cell cycle of normal and cancerous human cells. Biochemical and Biophysical Research Communications, 159,
1141-1146, 1989.
 

36. Riis, B., Rattan, S.I.S., Cavallius, J. and Clark, B.F.C. Levels of active elongation factor-2 in rat livers during
ageing. Topics in Aging Research in Europe, 13, 117-124, 1989.
 

35. Cavallius, J., Rattan, S.I.S. & Clark, B.F.C.A decrease in levels of mRNA for elongation factor-1a accompanies the
decline in its activity and the amounts of active enzyme in rat livers during ageing. Topics in Aging Research in Europe,
13, 125-132, 1989.
 

34. Riis, B., Rattan, S.I.S. and Clark, B.F.C.Estimating the amounts of ADP-ribosylatable elongation factor-2 in
mammalian cell-free extracts. Journal of Biochemical and Biophysical Methods 19, 319-326, 1989.
 

33. Rattan, S.I.S. DNA damage and repair during cellular aging. International Review of Cytology, 116, 47-88, 1989.
 

32. Rattan, S.I.S. Going in circles: what future for ageing research? BioEssays, 11, 3-4, 1989.
 

31. Riis, B. and Rattan, S.I.S.Alderdom og biokemi. Naturens Verden, No. 9, 329-336, 1989. (in Danish)

30. Rattan, S.I.S. and Riis, B.Biokemisk forskning i alderdom, hvorfor? Ugeskrift for Læger, 151, 3085-3086, 1989. (in
Danish)
 
 

1988

29. Rattan, S.I.S., Rasmussen, L.M., Bjerring, P., Bhatia, P. & Clark, B.F.C. Human plasma fibronectin levels during
ageing, Alzheimer ´s disease and cancer. Trends in Biomedical Gerontology, 1, 61-62, 1988.

28. Rattan, S.I.S., Cavallius, J., Madsen, A., Hartvigen, G. & Clark, B.F.C. Inhibition of protein elongation factor-1a
during heat shock of ageing and immortal human cells. Trends in Biomedical Gerontology, 1, 195-196, 1988.

27. Rattan, S.I.S., Rasmussen, L.M., Bjerring, P., Bhatia, P. & Clark, B.F.C.Unchanged concentrations of plasma
fibronectin in Alzheimer's disease. Journal of Clinical Pathology, 41, 476, 1988.

26. Rattan, S.I.S., Cavallius, J. & Clark, B.F.C. Heat shock-related decline in amounts of active elongation factor-1a
and its activity in ageing and immortal human cells. Biochemical and Biophysical Research Communications, 152,
169-176, 1988.

25. Rattan, S.I.S. & Clark, B.F.C.Ageing: a challenge for biotechnology. Trends in Biotechnology, 6, 58-62, 1988.

24. Rattan, S.I.S. Science behind spices: inhibition of platelet aggregation and prostaglandin synthesis. BioEssays, 8,
161-162, 1988.

23. Rattan, S.I.S. Finding differences in biochemistry: the case of ageing. Trends in Biotechnology, 6, 267-268, 1988.
 
 

1987

22. Bhatia, P., Rattan, S.I.S., Cavallius, J., & Clark, B.F.C.Withania somnifera (Ashawagandha), a so-called
rejuvenator, inhibits growth and macromolecular synthesis of human cells. Medical Science Research, 15, 515-516,
1987.

21. Rattan, S.I.S. & Bhatia, P. Genetic engineering: Fact, fiction and future. Indo-European Medical Journal, 2, (2),
27-29, 1987.

20. Rattan, S.I.S., Cavallius, J., Bhatia, P. & Clark, B.F.C. Protein elongation factor-1a in ageing rodent brain. In:
Aging - a multifactorial discussion (eds. K. Subba Rao & V. Prabhakar) pp 125-130, Association of Gerontology
Publishers, India, 1987.
 
 

1986

19. Rattan, S.I.S., Cavallius, J., Coppard, N.J., Mosses, D., Madsen, A. & Clark, B.F.C. Post-translational
methylation of elongation factor-1a in ageing and immortal human cells. Topics in Aging Research in Europe, 7,
132-145, 1986.

18. Cavallius, J., Rattan, S.I.S. & Clark, B.F.C. Changes in activity and amount of active elongation factor-1a in aging
and immortal human fibroblast cultures. Experimental Gerontology, 21,149-157, 1986.

17. Rattan, S.I.S., Cavallius, J., Hartvigsen, G. & Clark, B.F.C.Amounts of active elongation factor-1a and its activity
in livers of mice during ageing. Trends in Aging Research/ Colloque INSERM. 147, 135-140, 1986.

16. Rattan, S.I.S. Ageing and immortality. BioEssays, 4, 82-83, 1986.

15. Rattan, S.I.S. Ageing trends and the European effort. BioEssays, 5, 51-52, 1986.
 
 

1985

14. Holliday, R., Thompson, K.V.A., Huschtscha, L.I., Rattan, S.I.S., Sedgwick, S.G. & Spanos, A. Experimental
studies on Werner's syndrome fibroblasts. Advances in Experimental Medicine and Biology, 190, 331-339, 1985.

13. Rattan, S.I.S. Beyond the present crisis in gerontology. BioEssays, 2, 226-228, 1985.
 
 

1984

12. Holliday, R. & Rattan, S.I.S. Evidence that paromomycin induces premature ageing of human fibroblasts in
culture. Monographs in Developmental Biology, 17, 221-233, 1984.
 

11. Rattan, S.I.S.RNA recombination: a breakthrough in genetic engineering. Science Reporter, 21, 330-332, 1984.
 

1983

10. Rattan, S.I.S. Ageing outside the body. Science Today, 17 (8), 52-55, 1983.
 
 

1982

9. Rattan, S.I.S. & Buchanan, J.H. Optimum conditions for growth and longevity of chick embryo fibroblasts in culture.
Mechanisms of Ageing and Development, 19, 1-4, 1982.

8. Rattan, S.I.S., Keeler, K.D., Buchanan, J.H. & Holliday, R. Autofluorescence as an index of ageing in human
fibroblasts in culture. Bioscience Reports, 2, 561-567, 1982.

7. Rattan, S.I.S. Uptake, accumulation and release of paromomycin by human fibroblasts in culture.
IRCS Medical Sciences, 10, 807-808, 1982.

6. Buchanan, J.H., Rattan, S.I.S., Stevens, A. & Holliday, R.Intracellular accumulation of a fluorescsent derivative of
paromomycin in human fibroblasts. Journal of Cellular Biochemistry, 20, 71-82, 1982.
 

1979

5. Rattan, S.I.S. & Mookerjee, S.Altered profiles of RNA synthesis in a dimethyl sulphate mutant hydra. Indian Journal
of Experimental Biology, 17, 1007-1011, 1979.

4. Sharma, S.P., Rattan, S. & Sharma, G.Temperature dependent longevity of Zabrotes subfasciatus Boh. (Col.
Bruch.). Comparative Physiology and Ecology, 4, 229-231, 1979.
 

1977

3. Sharma, S.P., Sharma, G. & Rattan, S. The biological phenomenon of ageing. Everyday Science,22 (3), 1-4, 1977.
 
 

1976

2. Sharma, S.P. & Rattan, S.Lipofuscin - an index of ageing. Everyday Science, 21 (4), 35-36, 1976.

1. Sharma, S.P. & Rattan, S. Lysosome - the suicidal bag. Everyday Science,21 (2), 39-43, 1976.