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Distal Convoluted Tubule

figureThe distal convoluted tubule functions in much the same way as the thick ascending limb of Henle’s loop. It has a very low water permeability and a high basolateral Na+, K+-ATPase activity. Luminal transport is via a Na+, Cl- symporter. Basolateral transport is via the primary active Na+, K+- ATPase, a secondary active K+, Cl- symport and passive transport of K+. Solute reabsorption continues in the absence of water reabsorption and the tubular fluid is further diluted in its passage through the distal convoluted tubule.