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Bacterial Capnine Blocks Transcription of Human Antimicrobial Peptides

Trevor G. Marshall1

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  1. Murdoch University, Western Australia; Autoimmunity Research Foundation, California
Document Type:
Poster / Presentation
Received 21 June 2007 16:29 UTC; Posted 22 June 2007
Immunology, Microbiology, Bioinformatics

The US CDC believes that 65% of all infections in developed countries may be caused by pathogens in biofilms. Electron Microscopy has shown that these bacterial communities can evade phagocytosis, and persist in the cytoplasm of monocytes, macrophages, lymphocytes and neutrophils. Three decades ago, Wirostko et al. found such intraphagocytic communities in Crohn’s disease, Juvenile Rheumatoid Arthritis and Sarcoidosis. However, the mechanism(s) by which such persistent bacteria could evade the immune system have remained elusive. Recently, 16S RNA from species of gliding bacteria never thought to be able to survive in vivo, have been found in surgically removed biofilms. This study set out to identify whether the genomes of these gliding bacteria might yield insight into mechanisms by which such persistent pathogens could evade phagocytosis.

Presented at:
Metagenomics 2007, 11 July 2007



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Alfonso Islas on 22 August 2007 15:08 UTC

Antimicrobial peptides is an important, not new, but still emerging field in immunobiology.
Its application in infectious diseases is very important in humans, animals and plants.
Any effort to know more of antimicrobial peptides as an efficient arm of the innate immune response must be considered by our community.

Alfonso Islas
Universidad de Guadalajara

Alfonso Islas on 22 August 2007 15:16 UTC

Our group is developing strategies in order to use antimicrobial peptides in treatments of infectious diseases in mastitis in cows, and onychomycosis in humans.
We are in the second phase of research, after isolate and characterize antimicrobial peptides from the skin of the Rana catesbeiana, we are testing in vitro and in vivo its efficacy.

Alfonso Islas
Universidad de Guadalajara

Josiah Zayner on 24 August 2007 04:48 UTC

How do you prove it is a strong transciptional antagonist with Molecular Modeling? And again, you do not post the methods of performing your modeling, why not? Bacteria cannot live in a biofilm and at the same time live in a cell. Capnine has been shown to be associated with gliding, nothing else. Has anyone even shown that bacteria intraphagocytotically release capnine? What capnine did you use in your modeling, they vary in length? None of the bacteria isolated by Dempsey et al. belong to a genera of capnine producing bacteria!

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This document is licensed to the public under the Creative Commons Attribution 2.5 License
How to cite this document:

Marshall, Trevor. Bacterial Capnine Blocks Transcription of Human Antimicrobial Peptides. Available from Nature Precedings <> (2007)

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