North Head was the first site in Australia to be used for quarantine purposes, when the Bussorah Merchant was detained in Spring Cove, Sydney, in 1828. For almost 150 years North Head Quarantine Station helped protect Australia's island nation from disease. North Head is recognised as the entrance to one of the world's most picturesque harbours, Port Jackson, and has been portrayed by artists such as Augustus Earle from as early as 1825.
The Quarantine Station was added to the Sydney Harbour National Park in 1984. The facility is today used as a centre for events and conferences and as a tourist attraction.
North Head was included in the National Heritage List on 12 May 2006.
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