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Abell
Alavi
Althorpe
Balasubramanian
Bampos
Barker
Best
Blumberger
Clarke J
Clarke S
Cox
Davies
Day
Dobson
Duer
Elliott
Fersht
Frenkel
García
Gaunt
Glen
Goodman
Grant
Huck
Jackson
Jefferson
Jenkins
Jones R
Jones W
Keeler
King
Klenerman
Klinowski
Lambert
Leeper
Ley
Mackenzie
Miller
Mitchell
Murray-Rust
Nitschke
Nolan
O'Reilly
Otto
Paterson
Pyle
Rawson
Robinson
Sanders
Scherman
Smith
Sprik
Spring
Taraskin
Vendruscolo
Wales
Warren
Wheatley
Wood
Wothers
Wright
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Our research in biological chemistry is strongly interdisciplinary and involves enzymology, organic
synthesis, protein crystallography, molecular biology, and scanning probe microscopy. Current areas of
interest include:
- The use of microdroplets for reactions in biology and chemistry with Dr Wilhelm Huck, Professor
Carol Robinson, Dr Florian Hollfelder, [Biochemistry] and Professor Andrew deMello, [Imperial
College]).
- The mechanism and inhibition of enzymes on the shikimate and pantothenate pathways. Inhibitors
are of potential importance as antimicrobial or anti-parasitic agents.
- Novel fragment-based approaches to enzyme inhibition (in collaboration with Professor Tom
Blundell, Biochemistry).
- The chemistry, biochemistry and molecular biology of riboswitches in bacteria and plants (in
collaboration with Dr Finian Leeper, Dr Alison Smith [Plant Sciences], and Professor Martin Warren
[Kent]).
- Chemical and biological nanotechnology, e.g. using a nanopipette to develop novel biosensors
(with Dr David Klenerman and Professor Lisa Hall [Biotechnology]).
(L) chorismate modelled into the active site of ADC synthase (R) University crest drawn in fluorescently-labelled DNA using a nanopipette
Selected Recent Publications
Identification of 4-amino-4-deoxychorismate synthase as the molecular target for the
antimicrobial action of (6S)-6-fluoroshikimate. J. Am. Chem. Soc. 2004,
126, 9912-9913
An addressable antibody nanoarray produced on a nanofabricated surface. J. Am. Chem.
Soc. 2004, 126, 6508-6509
Crystal structures of Yersinia enterocolitica salicylate synthase and its complex with
the reaction products salicylate and pyruvate. J. Mol. Biol. 2006, 357,
524-534.
The application of fragment screening and fragment linking to the discovery of novel thrombin
inhibitors. J. Med. Chem. 2006, 49, 1346-1355
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