For centuries, the pomegranate has been valued as a symbol of health. Could the legends have some basis in fact? In 1998, research began in an effort to get some answers.
A number of top scientists in their fields, including a Nobel Laureate, are researching areas covering antioxidant activity, cardiovascular disease, circulation, cancer and others. To date, multiple pilot, peer-reviewed studies have been completed and published, while a number of others are still in progress.
To learn more about the studies, please click any of the following areas of research:
Pomegranate juice helps promote healthy coronary endothelial cells by enhancing nitric oxide.
de Nigris F, Williams-Ignarro S, Botti C, Sica V, Ignarro LJ, and Napoli C.
Nitric Oxide. 15(3):259-63, 2006
Pomegranate juice protects nitric oxide against oxidative destruction and enhances the biological actions of nitric oxide.
Ignarro LJ, Byrns RE, Sumi D, de Nigris F, Napoli C.
Nitric Oxide 15(2):93-102, 2006
Pomegranate juice improves myocardial perfusion in coronary heart patients.
Summer, MD, Elliott-Eller, M, Weidner, G, Daubenmier, JJ, Chew, MH, Marlin, R, Raisin, CJ, and Ornish, D.
American Journal of Cardiology 2005, 96: 810-814
Pomegranate juice pilot research suggest anti-atherosclerosis benefits.
Aviram, M, Rosenblat, M, Gaitini, D, Nitecki, S, Hoffman, A, Dornfeld, L, Volkova, N, presser, D, Attias, J, Liker, H and Liker, H.
Clinical Nutrition, 2004, 23: 423-433
Pomegranate juice helps promote normal systolic blood pressure.
Aviram, M and Dornfeld, L.
Atherosclerosis 158, 195-198, 2001
Pomegranate juice delays PSA doubling time in humans.
Pantuck, AJ, Leppert, JT, Zomorodian, N, Aronson, W, Hong, J, Barnard, RJ, Seeram, N, Liker, H, Wang, H, Elashoff, R, Heber, D, Aviram, M, and Belldegrun, A.
Clinical Cancer Research 12(13): 4018-4026, 2006
Pomegranate polyphenols have anti-inflammatory effects on colon cancer cells.
Adams, LS, Seeram, NP, Aggarwal, BB, Takada, Y, Sand, D, and Heber, D.
Journal of Agricultural and Food Chemistry 54: 980-985, 2006
Pomegranate juice shows superior anti-cancer bioactivity when compared to its purified compounds.
Seeram, N, Adams, LS, Henning, SM, Niu, Y, Zhang, Y, Nair, MG and Heber, D
Journal of Nutritional Biochemistry 16: 360-367, 2005
Efficacy and safety of pomegranate juice on improvement
of erectile dysfunction in male patients with mild to moderate
erectile dysfunction: a randomized, placebo-controlled,
double-blind, crossover study.
CP Forest, H Padma-Nathan and HR Liker
International Journal of Impotence Research 19: 564-567, 2007
Comparison of Antioxidant Potency of Commonly
Consumed Polyphenol-Rich Beverages in the United States.
Navindra P. Seeram, Michael Aviram, Yanjun Zhang, Susanne M. Henning, Lydia Feng, Mark Dreher, and David Heber
Journal of Agricultural and Food Chemistry, published online January 26, 2008
Composition of pomegranate polyphenols.
Reed, JD, Krueger, CG and Vestling, MM.
Phytochemistry 66: 2248-2263, 2005
Pomegranate juice is rich in potent polyphenols antioxidants.
Gil, MI, Tomas-Barberan, FA, Hess-Pierce, B, Holcroft, DM, and Kader, AA
Journal of Agricultural and Food Chemistry 48: 4581-4589, 2000
Specific POMx components are potent antioxidants and bioactive
Reddy, MK, Gupta, SK, Jacob, MR, Khan, SI and Ferreira, D.
Planta Medica 1-7, 2007.
Pomegranate juice has antioxidant benefits for people with type 2 diabetes.
Rosenblat, M, Hayek, T and Aviram, M. 2005
Atherosclerosis 187(2): 363-371, 2006
Pomegranate juice stimulates unique antioxidant function relevant to diabetes.
Rosenblat, M, Karry, R, and Aviram, M.
Atherosclerosis 187(1): 74-81, 2006
Pomegranate juice polyphenol are bioavailable up to 48 hours.
Seeram NP, Henning SM, Zhang Y, Suchard M, Li Z, Heber D.
Journal of Nutrition 136(10):2481-5, 2006
Pomegranate juice polyphenols are bioavailable.
Seeram, N, Lee, R, and Heber, D.
Clinica Chimica Acta 348: 63-68, 2004