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The Science of POM Wonderful

For centuries, the pomegranate has been valued as a symbol of health. Could the legends have some basis in fact? In 1998, research began in an effort to get some answers.

A number of top scientists in their fields, including a Nobel Laureate, are researching areas covering antioxidant activity, cardiovascular disease, circulation, cancer and others. To date, multiple pilot, peer-reviewed studies have been completed and published, while a number of others are still in progress.

To learn more about the studies, please click any of the following areas of research:

Cardiovascular Studies

Pomegranate juice helps promote healthy coronary endothelial cells by enhancing nitric oxide.
de Nigris F, Williams-Ignarro S, Botti C, Sica V, Ignarro LJ, and Napoli C.
Nitric Oxide. 15(3):259-63, 2006

Pomegranate juice protects nitric oxide against oxidative destruction and enhances the biological actions of nitric oxide.
Ignarro LJ, Byrns RE, Sumi D, de Nigris F, Napoli C.
Nitric Oxide 15(2):93-102, 2006

Pomegranate juice improves myocardial perfusion in coronary heart patients.
Summer, MD, Elliott-Eller, M, Weidner, G, Daubenmier, JJ, Chew, MH, Marlin, R, Raisin, CJ, and Ornish, D.
American Journal of Cardiology 2005, 96: 810-814

Pomegranate juice pilot research suggest anti-atherosclerosis benefits.
Aviram, M, Rosenblat, M, Gaitini, D, Nitecki, S, Hoffman, A, Dornfeld, L, Volkova, N, presser, D, Attias, J, Liker, H and Liker, H.
Clinical Nutrition, 2004, 23: 423-433

Pomegranate juice helps promote normal systolic blood pressure.
Aviram, M and Dornfeld, L.
Atherosclerosis 158, 195-198, 2001

Cancer Studies

Pomegranate juice delays PSA doubling time in humans.
Pantuck, AJ, Leppert, JT, Zomorodian, N, Aronson, W, Hong, J, Barnard, RJ, Seeram, N, Liker, H, Wang, H, Elashoff, R, Heber, D, Aviram, M, and Belldegrun, A.
Clinical Cancer Research 12(13): 4018-4026, 2006

Pomegranate polyphenols have anti-inflammatory effects on colon cancer cells.
Adams, LS, Seeram, NP, Aggarwal, BB, Takada, Y, Sand, D, and Heber, D.
Journal of Agricultural and Food Chemistry 54: 980-985, 2006

Pomegranate juice shows superior anti-cancer bioactivity when compared to its purified compounds.
Seeram, N, Adams, LS, Henning, SM, Niu, Y, Zhang, Y, Nair, MG and Heber, D
Journal of Nutritional Biochemistry 16: 360-367, 2005

Erectile Dysfunction

Efficacy and safety of pomegranate juice on improvement of erectile dysfunction in male patients with mild to moderate erectile dysfunction: a randomized, placebo-controlled, double-blind, crossover study.
CP Forest, H Padma-Nathan and HR Liker
International Journal of Impotence Research 19: 564-567, 2007

Antioxidant Composition Studies

Comparison of Antioxidant Potency of Commonly Consumed Polyphenol-Rich Beverages in the United States.
Navindra P. Seeram, Michael Aviram, Yanjun Zhang, Susanne M. Henning, Lydia Feng, Mark Dreher, and David Heber
Journal of Agricultural and Food Chemistry, published online January 26, 2008

Composition of pomegranate polyphenols.
Reed, JD, Krueger, CG and Vestling, MM.
Phytochemistry 66: 2248-2263, 2005

Pomegranate juice is rich in potent polyphenols antioxidants.
Gil, MI, Tomas-Barberan, FA, Hess-Pierce, B, Holcroft, DM, and Kader, AA
Journal of Agricultural and Food Chemistry 48: 4581-4589, 2000

Specific POMx components are potent antioxidants and bioactive
Reddy, MK, Gupta, SK, Jacob, MR, Khan, SI and Ferreira, D.
Planta Medica 1-7, 2007.

Diabetes Studies

Pomegranate juice has antioxidant benefits for people with type 2 diabetes.
Rosenblat, M, Hayek, T and Aviram, M. 2005
Atherosclerosis 187(2): 363-371, 2006

Pomegranate juice stimulates unique antioxidant function relevant to diabetes.
Rosenblat, M, Karry, R, and Aviram, M.
Atherosclerosis 187(1): 74-81, 2006

Bioavailability Studies

Pomegranate juice polyphenol are bioavailable up to 48 hours.
Seeram NP, Henning SM, Zhang Y, Suchard M, Li Z, Heber D.
Journal of Nutrition 136(10):2481-5, 2006

Pomegranate juice polyphenols are bioavailable.
Seeram, N, Lee, R, and Heber, D.
Clinica Chimica Acta 348: 63-68, 2004

Healthcare Professionals