Coomassie Brilliant Blue staining of proteins on PVDF


CBB solution

For 1L stain make the following:

  • 0.5% Coomassie brilliant blue ( 0.5 g
  • 40% methanol (400 mL)
  • 10% acetic acid (100 ml)
  • milli-Q H2O

Dissolve in methanol by stirring for 20 min. let the CBB rest for 15 min and then decant contents into acetic acid.
 

Destaining solution

  • 30% methanol
  • 10% acetic acid

Gel staining/destaining protocol

  • stain gel in CBB solution for 30 minutes on shaking platform
  • destain until background is transparent and bands are visible
  • wash gel 3-5 times with H2O

PVDF staining/destaining protocol

  • stain PVDF membrane in CBB solution for 30 seconds
  • destain until background is transparent and bands are visible
  • wash gel 3-5 times with H2O