The Kedron area was originally thick bush with an abundance of good quality timber, including stringy bark, ironbark, bloodwood, blue gum, and spotted gum. Kangaroo, wallaby, and koala were abundant, and possums and feather gliders came out at night. Finches and assorted parrots filled the skies and Kedron Brook was alive with mullet, eels, and tortoises.
In 1959 the creek was described as being a fairy-like stream with wattle and ti-trees along the bank surrounded by flowers and vines and ground orchids. However, by 1886 the creek had become so polluted by the various tanneries, slaughter yards and piggeries along its course, that by-laws were passed which made it an offence to establish noxious industries along the creek, or to pollute the stream in any way. Unfortunately, rubbish dumps remained in the region and increased urbanisation over the years led to the silting up of the creek.
The 1980–81 Brisbane Wildlife survey found that there were fifty species of birds in the Kedron area, nine species of reptiles, and bandicoots, flying foxes, and brush-tail and ringtail possums still lived in the region.
In recent years the Queensland Wildlife Preservation Society has been carrying out the Kedron Brook Rehabilitation Project with the Brisbane City Council. Tasks included dredging parts of the creek to establish native fish habitats and replanting native vegetation along the banks.