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Cholesterol & Atherosclerosis –
the Artery Connection

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Managing Cholesterol

Managing Cholesterol

Cholesterol is a fatty substance, also called a lipid, that's produced by the liver. It's also found in foods high in saturated fat, like fatty meats, egg yolks, shellfish, and whole-milk dairy products. It's a vital part of the structure and functioning of our cells. However, too much cholesterol in your blood may lead to a serious, progressive disease of the arteries, called atherosclerosis.

A Closer Look

So how can something your body needs be harmful? Well, not all cholesterol is considered bad. There are actually three main components doctors evaluate when you have a blood test to check your cholesterol. They look at LDL (bad) cholesterol, HDL (good) cholesterol, and another substance called triglycerides.

The fact is that cholesterol can be harmful to your health when there's too much cholesterol in your blood. Whether you have high cholesterol may depend on your lifestyle. Eating a lot of fats and not getting enough exercise can cause cholesterol levels to rise. It's also, in part, a result of your genetic makeup. Some people inherit genes associated with elevated levels of cholesterol. One type is called familial hypercholesterolemia. People with this genetic makeup can eat a healthy diet and exercise, and still have high cholesterol.

Everyone with high cholesterol needs to keep it under control, but it may be even more important for some groups of people, such as

  • People with a family history of early heart disease
  • People with high blood pressure
  • People with diabetes
  • Males over age 45
  • Females over age 55
  • Smokers
  • African Americans
  • Hispanic Americans

If you fall into any of the categories above, ask your doctor to discuss how your cholesterol goals may be affected.

What's Your Cholesterol Goal?

Managing high cholesterol may be different for you depending on your medical history and your health. Your doctor will look at the results of your cholesterol test, also known as a fasting lipid profile, and, using this information along with your medical background, establish a cholesterol goal for you. Always ask what your cholesterol numbers mean, based on your complete health history so you can work together to manage your cholesterol.

Cholesterol Guidelines

National Cholesterol Education Program (NCEP) guidelines recommend that all adults over age 20 have their cholesterol checked at least once every 5 years. Take a look at the guidelines below to get a better idea of where your cholesterol numbers should be.

Total cholesterol level
  • Less than 200 mg/dL
  • 200-239 mg/dL
  • 240 mg/dL or higher
 
  • Desirable
  • Borderline high
  • High
Total cholesterol is based on your LDL cholesterol (LDL-C) and HDL cholesterol (HDL-C) counts. Generally, a lower number is better.
LDL-C
  • Less than 100 mg/dL
  • 100-129 mg/dL
     
  • 130-159 mg/dL
  • 160-189 mg/dL
  • 190 mg/dL or higher
 
  • Optimal
  • Near optimal / above optimal
  • Borderline high
  • High
  • Very high
LDL-C is considered the "bad" cholesterol because if you have too much LDL-C in your bloodstream, it can lead to the buildup of plaque in your arteries known as atherosclerosis. Generally, lower is better.
HDL-C
  • 60 mg/dL or higher
  • Less than 40 mg/dL
 
  • High
  • Low
HDL-C is considered the "good" cholesterol because it helps return cholesterol to the liver, where it can be eliminated from the body. Generally, higher is better.

Triglycerides
  • Less than 150 mg/dL
  • 150-199 mg/dL
  • 200-499 mg/dL
  • 500 mg/dL or higher
 
  • Normal
  • Borderline high
  • High
  • Very high
Triglycerides, like cholesterol, are another substance that can be dangerous to your health. Like LDL-C, you want to keep your triglycerides low.

Source: National Cholesterol Education Program (NCEP)

Depending on your overall health profile - which takes into consideration factors such as cigarette smoking, hypertension, low HDL cholesterol, a family history of early heart disease, and age (over 45 for men and over 55 for women) - your doctor may recommend that you have your cholesterol followed more closely.

It's important to manage your cholesterol and reach your goals because if you don't, your high cholesterol may contribute to the progression of atherosclerosis, the buildup of plaque in your arteries.

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The information on this Web site should not take the place of talking with your doctor or health care professional about how to manage and treat your cholesterol. If you have any questions about your cholesterol or how it may be contributing to the progression of atherosclerosis, or if you would like more information about CRESTOR, talk to your doctor or pharmacist. Only you and your doctor can decide if CRESTOR is right for you.

Important safety information about CRESTOR
In adults, CRESTOR is prescribed along with diet for lowering high cholesterol. CRESTOR is also prescribed along with diet to slow the progression of atherosclerosis (the build up of plaque in arteries) as part of a treatment plan to lower cholesterol to goal. CRESTOR has not been determined to prevent heart disease, heart attacks, or strokes.

CRESTOR is not right for everyone, including anyone who has previously had an allergic reaction to CRESTOR, anyone with liver problems, or women who are nursing, pregnant, or who may become pregnant. Your doctor will do blood tests before and during treatment with CRESTOR to monitor your liver function. Unexplained muscle pain and weakness could be a sign of a rare but serious side effect and should be reported to your doctor right away. The 40 mg dose of CRESTOR is only for patients who do not reach goal on 20 mg. Be sure to tell your doctor if you are taking any medications. Side effects occur infrequently and include headache, muscle aches, abdominal pain, weakness, and nausea.

Please see full Prescribing Information for CRESTOR.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.FDA.gov/medwatch or call 1-800-FDA-1088.

CRESTOR was licensed by AstraZeneca from Shionogi & Co LTD, Osaka, Japan.

CRESTOR is a registered trademark and CRESTOR 360° is a trademark of the AstraZeneca group of companies.

©2008 AstraZeneca Pharmaceuticals LP. All rights reserved. 260827 5/08

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Play Video Get tips on starting a meaningful conversation with your doctor about cholesterol.

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tetete

The buildup of plaque in your arteries, known as atherosclerosis, can start in early adulthood

In addition to high cholesterol, do you have other health factors that contribute to the development of atherosclerosis?