Venue: Anfield Date: Saturday, 13 September Kick-off: 1245 BST Coverage: Full commentary on BBC Radio Merseyside 95.8 FM, 1485 MW and DAB digital, plus BBC Sport website, BBC Radio Five Live, highlights on Match of the Day and live on Sky Sports 1
Liverpool duo Steven Gerrard and Fernando Torres have both been declared fit to face Manchester United.
Gerrard missed England's 4-1 win in Croatia on Wednesday after undergoing a minor groin operation, while Torres has recovered from a hamstring tear.
Dimitar Berbatov is set to make his Man Utd debut after signing from Tottenham for £30.75m on transfer deadline day.
Owen Hargreaves (tendinitis) and Michael Carrick (ankle) both return for the trip to Anfield.
The news that Gerrard and Torres are in line to face United will be a big boost for Liverpool.
Rafael Benitez is desperate to beat Man Utd
Torres pulled up during his side's 0-0 draw with Aston Villa last month and missed Spain's recent World Cup qualifiers, while Gerrard has struggled with his groin injury since the start of the season.
Robbie Keane is likely to start alongside the Spanish striker as he searches for his first competitive goal for the Reds, while Albert Riera is in line to make his Liverpool bow after signing from Espanyol.
Sir Alex Ferguson's side have held the upper hand over their north west rivals in recent seasons, winning five and drawing one of their last six league games.
United have a clean bill of health, although the match comes too soon for Cristiano Ronaldo who is expected to return against Villarreal at Old Trafford on Wednesday.
Man Utd (from): Van der Sar, Kuszczak, Foster, Neville, Brown, R Da Silva, Ferdinand, Vidic, Evans, Evra, F Da Silva, Fletcher, O'Shea, Hargreaves, Carrick, Anderson, Scholes, Nani, Possebon, Gibson, Giggs, Rooney, Tevez, Berbatov, Welbeck.
Liverpool manager Rafael Benitez on Gerrard and Torres:
"They are both much better. They came through a full training session this morning.
"It's important for us to have these two players of quality who can change a game.
"I'm not surprised they are available because the medical staff have done a good job and the players have been working really hard with the physios to get fit."
Liverpool can go three points clear at the top of the table for two hours at least, if they can record a 10th successive home league win, at the expense of champions Manchester United.
The Red Devils were the only club to leave Anfield with all three points last season.
Sir Alex Ferguson, who's eager to match Liverpool's 18 league titles this season by winning a third consecutive Premier League crown, holds an unbeaten league record against his opposite number Rafa Benitez of seven wins and one draw. Benitez' only success was Liverpool's fifth round victory in the FA Cup in February 2006.
Both these clubs have lost just two Premier League matches in 2008, and will be looking for a morale boosted performance ahead of their first Champions League group matches next week.
Liverpool are vying for a 50th victory from their 151st league meeting with Manchester United.
The Red Devils are chasing a sixth successive Premier League victory over Liverpool, and third in a row at Anfield.
Liverpool have suffered more Premier League defeats (18), dropped more points (68) and conceded more goals (48) to Manchester United than to any other club.
Distance between the clubs: 33 miles (54 kilometres) Manchester United are making the shortest journey of all Premier League clubs this weekend.
Edwin VAN DER SAR will be making his 300th start for an English club (Fulham and Manchester United).
Gary NEVILLE will be making his 350th Premier League start for Manchester United.
John O'SHEA will be making his 150th English league start (Manchester United and Bournemouth).
HEAD TO HEAD
The Merseysiders have only won 25% of their home matches against Manchester United in the Premier League (four of 16).
The champions did the double over Liverpool for the fifth time in the Premier League last season, and the third time in four seasons.
United have not lost in six consecutive league visits to Anfield, since Liverpool's 3-1 triumph on 4 November 2001; Michael Owen scored a brace and John Arne Riise also netted in that match seven years ago.
The only point in 24 Liverpool have notched against United came from a goalless draw at Anfield on 18 September 2005.
Since the start of the 2002-03 season, Liverpool have played 115 home Premier League matches and lost just 13 of them - five to Manchester United. The Red Devils have a better record at Anfield than any other Premier League club.
Home and away
League (inc PL): Liverpool 49 wins, Man Utd 58, Draws 43
Prem: Liverpool 7 wins, Man Utd 18, Draws 7
at Liverpool only
League (inc PL): Liverpool 35 wins, Man Utd 22, Draws 18
Prem: Liverpool 4 wins, Man Utd 9, Draws 3
LAST SEASON'S CORRESPONDING GAME
Liverpool 0-1 Manchester United
16 December 2007 - Ref: Mark Halsey
Man Utd scorer: Tevez 43
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