Rosetta Commons aims to develop high resolution protein prediction and design software broadly available to the scientific community without reach-through or other restrictive terms. The Rosetta Commons provides for an environment of continuous sharing and collaborative development in the context of the Rosetta platform.

Our Goal

The Rosetta++ software focuses on the prediction and design of protein structures, protein folding mechanisms, and protein-protein interactions. Rosetta codes consistently exhibit repeated success in the Critical Assessment of Techniques for Protein Structure Prediction (CASP) competition as well as the CAPRI competition and additionally have been modified to address aspects of protein design, docking and structure.


This software is currently licensed for free to hundreds of academic labs in 32 countries, as well as on a fee-basis to drug discovery companies. The code is also the foundation for the Human Proteome Folding Project on the World Community Grid. Revenue generated to date has been utilized for continued software development.

Our Research

Structures of designed enzymes. Jiang L, et al(2008).De novo computational design of retro-aldol enzymes.Science 319, 1387-91.
1.6 Å C{alpha}-RMSD blind structure prediction for CASP6 target T0281, hypothetical protein from Thermus thermophilus Hb8.(Bradley P, Misura KM, Baker D, Science. 2005 Sep 16;309(5742):1868-71.)
Ribbon diagrams of Top7 with residues 46 to 76 highlighted in red -- A novel protein structure created with RosettaDesign.(Kuhlman B, Dantas G, Ireton GC, Varani G, Stoddard BL, Baker D, Science 302, 1364-8.)