Publications and Medical Research

Below are links to research publications and medical reseach papers on Curaderm BEC5 and skin cancer

Cham, B. E. and Wilson, L. (1987) HPLC of glycoalkaloids from Solanum sodomaeum L. Planta Med. 53, 59-61
Chen, Z. and Miller, A. (2001) Steroidal Alkaloids in solanaceous vegetable crops. (2001). Horticul. Rev. 25. 171-186
Jones, P.G. and Fenwick, G.R. (1981) The glycoalkaloid content of some edible Solanaceous fruits and potato products. J. Sci, Food Agric. 32. 419-421
Lequart, V., Goethals, G., Banoub, J., Villa, P. and Martin, P. (2004) An Improved Synthesis of Chacotriose. Chem. Let. 33. 444
Morillo, M., Lequart, V., Grand, E., Goethals, G., Usubillaga, A., Villa, P. and Martin, P. (2001) Synthesis of peracetylated chaco-triose. Carbohyd. Res. 334, 281-287
Nada, C., Nikolic, A., Mihajlo, Z., Stankovic, A. G., Dejan, Z. and Markovic, C. D. (2005) Liquid-liquid systems for acid hydrolysis of glycoalkaloids from Solanum tuberosum L. tuber sprouts and solanidine extraction. Med. Sci. Monit. 11(7). BR200-205
Schreiber, K. (1968) Steroidal alkaloids: The Solanum group. In the alkaloids Vol 10, (Mansk, K., Ed.). Academic Press.
Cham, B. E. (1988) Monograph on the compound BEC. Drugs of the Future. 13, 714-716
Daunter, B. and Cham, B. E. (1990) Solasodine glycosides. In vitro preferential cytotoxicity for human cancer cells. Cancer Letters 55, 209-220
Cham, B. E. (1989) Curaderm (antineoplastic). Launched in Australia. Drug News and Perspectives 2, 112
Cham, B. E. (1991) Solasodine glycosides: A new modality for cancer. In Proc. 2nd Oceania Symposium. p.30-36. Editor Mark S. Walker. Bioconcepts Publishing.
Cham, B. E. (1994) Solasodine glycosides as anti-cancer agents: Pre-clinical and clinical studies. Asia Pacif. J. Pharmacol. 9, 113-118
Cham, B. E. (1993) Efficacy and mode of action of solasodine glycosides (BEC) on cancer cells. In Proc. 4th Oceania Symposium 0041-51. Editor Mark S. Walker. Bioconcepts Publishing.
Chataing, B., Christancho, N. B. and Usubillaga, A. (1998) Topical treatment of herpes simplex, herpes zoster and genital herpes with a mixture of Solanaceous glycoalkaloids. MedULA. Universidad de Los Andes. 7. 30-34
Kuo, K. W., Hsu, S. H., Li, Y. P., Lin, W. L., Liu, L. F., Chang, L. C., Lin, C. C., Lin, C. N. and Sheu, H. M. (2000). Anticancer activity evaluation of the Solanum glycoalkaloid solamargine. Triggering apoptosis in human hepatoma cells. Biochem. Pharmacol. 60, 1865-1873
Putalun, W., Taura, F., Qing, W., Matsushita, H., Tanaka, H and Shoyama, Y. (2003) Anti-solasodine glycoside single-chain Fv antibody stimulates biosynthesis of solasodine glycoside in plants. Plant Cell Rep. 22. 344-349
Vijayan, P., Vinod Kumar, S., Dhanaraj, S. A., Badami, S. and Suresh, B. In Vitro Cytotoxicity and Anti-tumour Properties of the Total Alkaloid Fraction of Unripe Fruits of Solanum pseudocapsicum. Pharmaceut. Biol. 40. 456-460
Cham, B. E., Gilliver, M. and Wilson, L. (1987) Antitumour effects of glycoalkaloids isolated from Solanum sodomaeum L. Planta Med. 53, 34-36
Amalfi, C. (2006) The little mouse who wouldn’t say die. Cosmos Mag. 471.
Badami, S., Manohara Reddy, S.A., Kumar, E.P., Vijayan, P. and Suresh, B. (2003) Antitumour activity of total alkaloid fraction of Solanum pseudocapsicum leaves. Phytother. Res. 17. 1001-1004
Chataing, B., Concepcion, J. L., Lobaton, R. and Usubillaga, A. (1998) Inhibition of Trypanosomer cruzi growth in vitro by Solanum alkaloids; a comparison with ketoconazole. Planta Med. 64, 31-36
Chami, L.A., Méndez, R., Chataing, B., O’Callaghan, J., Usubillaga, A. and LaCruz, L. (2003) Toxicological effects of a-solamargine in experimental animals. Phyto Res. 17, 254-258
Chang, L. C., Tsai, T. R., Wang, J. J., Lin, C. N. and Kuo, K. W. (1998) The rhamnose moity of solamargine plays a crucial role in triggering cell death by apotosis. . Biochem. Biophys. Res. Commun. 242, 21-25
Esteves-Souza, A., Silva, T. M. and Alves, C. C. F. et al. (2002) Cytotoxic activities against Ehrlich carcinoma and human K562 leukaemia of alkaloids and flavonoids from two Solanum Species. J. Braz. Chem. Soc. 13. 838-842
Hsu, S. H., Tsai, T. R., Lin, C. N., Yen, M. H. and Kuo, K. W. (1996) Solamargine purified from Solanum incanum Chinese herb triggers gene expression of human TNFR1 which may lead to cell apoptosis. Biochem. Biophys. Res. Commun. 229, 1-5
Evans, R., Cham, B. E. and Daunter, B. (1989) Letter to the Editor. Your Pharmacy, January
Cham, B. E., Daunter, B and Evans, R. (1990) Curaderm. Med. J. Australia. 152, 329-330
Cham, B. E., Daunter, B. (1990) Topical treatment of pre-malignant and malignant skin cancers with Curaderm. Drugs of Today 26, 55-58
Cham, B. E. (1989) Plants yield skin cancer cure. Austral. Technol. Rev. 2, 53
Millward, M., Powell, A., Daly, P., Tyson, S., Ferguson, R. and Carter, S. (2006) Results of phase I clinical trials of Coramsine in patients with advanced solid tumours. J. Clin. Oncol. 24, 2070
Nakamura, T., Komori, C., Lee, Y., Hashinoto, F., Yahara, S., Nohara, T., and Ejina, A. (1996) Cytotoxic activities of Solanum steroidal glycosides. Biol. Biopharm. Bull. 19, 564-566
Roddick, J. G., Rÿrenber, A. L. and Weissenberg, M. (1990) Membrane-disrupting properties of the steroidal glycoalkaloids Solasonine and Solamargine. Phyto. Chem. 29. 1513-1518
Jellinek, N. and Maloney, M. (2005) Escharotic and other botanical agents for the treatment of skin cancer: A review J. Amer. Aca. Dermatol. 53. 486-495
Moss, R. W. (1998) Herbs against cancer History and controversy. Equinax press, Inc. Brooklyn, N.Y.
Punjabi, S., Cook, I., Kersey, P., Marks, R., Finlay, A., Sharpe, G. et al. (2000) A double blind, multi-centre parallel group study of BEC-5 cream in basal cell carcinoma. Eur. Acad. Dermatol. Venereol. 14 (Suppl), 47-60
Walsh, N. (2000) Promising Topical Therapy for Actinic Keratoses Brief Article Dr S Punjabi. Uni. Liverpool. Family Pratice News. December 1 article.
Williams, D. G. (1995) The skin cancer cure nobody wants you to know about. Alternatives, 6, 17-22. Mountain Home Publishing.
Williams, D. G. (1995). The skin cancer cure so effective, it’s being kept secret. Ingram, TX: Mountain Home Publishing.
Dr Calméz Ltd. Curaderm Website
Sussman, L.A.E. and Liggins, D.F. (1996) Incompletely excised basal cell carcinoma: a management dilemma? Aust. NZ. J. Surg. 66, 276-278
Cerio, R. and Punjabi, S. (2002) Clinical Appraisal of BEC5. Barts and The London NHS.
Ono, M., Nishimura, K., Suzuki, K., Fukushima, T., Igoshi, K., Yoshimitsu, H., Ikeda, T and Nohara, T. (2006) Steroidal Glycosides from the Underground Parts of Solanum Sodomaeum. Chem. Pharm. Bull. 54(2)230-233