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myelodysplastic syndrome  any of a group of related bone marrow disorders of varying duration preceding the development of overt acute myelogenous leukemia; they are characterized by abnormal hematopoietic stem cells, anemia, neutropenia, and thrombocytopenia. Splenomegaly, hepatomegaly, and lymphadenopathy may not occur until the onset of leukemia, which may be explosive. Called also preleukemia.




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