Triggering of Acute Myocardial Infarction by Heavy Physical Exertion -- Protection against Triggering by Regular Exertion
Murray A. Mittleman, Malcolm Maclure, Geoffrey H. Tofler, Jane B. Sherwood, Robert J. Goldberg, James E. Muller, for The Determinants of Myocardial Infarction Onset Study Investigators
Background Despite anecdotal evidence suggesting that heavyphysical exertion can trigger the onset of acute myocardialinfarction, there have been no controlled studies of the riskof myocardial infarction during and after heavy exertion, thelength of time between heavy exertion and the onset of symptoms(induction time), and whether the risk can be modified by regularphysical exertion. To address these questions, we collecteddata from patients with confirmed myocardial infarction on theiractivities one hour before the onset of myocardial infarctionand during control periods.
Methods Interviews with 1228 patients conducted an average offour days after myocardial infarction provided data on theirusual annual frequency of physical activity and the time, type,and intensity of physical exertion in the 26 hours before theonset of myocardial infarction. We compared the observed frequencyof heavy exertion (6 or more metabolic equivalents) with theexpected values using two types of self-matched analyses basedon a new case-crossover study design. The low frequency of heavyexertion during the control periods was validated by data froma population-based control group of 218 subjects.
Results Of the patients, 4.4 percent reported heavy exertionwithin one hour before the onset of myocardial infarction. Theestimated relative risk of myocardial infarction in the hourafter heavy physical exertion, as compared with less strenuousphysical exertion or none, was 5.9 (95 percent confidence interval,4.6 to 7.7). Among people who usually exercised less than one,one to two, three to four, or five or more times per week, therespective relative risks were 107 (95 percent confidence interval,67 to 171), 19.4 (9.9 to 38.1), 8.6 (3.6 to 20.5), and 2.4 (1.5to 3.7). Thus, increasing levels of habitual physical activitywere associated with progressively lower relative risks. Theinduction time from heavy exertion to the onset of myocardialinfarction was less than one hour, and symptoms usually beganduring the activity.
Conclusions Heavy physical exertion can trigger the onset ofacute myocardial infarction, particularly in people who arehabitually sedentary. Improved understanding of the mechanismsby which heavy physical exertion triggers the onset of myocardialinfarction and the manner in which regular exertion protectsagainst it would facilitate the design of new preventive approaches.
Source Information
From the Institute for Prevention of Cardiovascular Disease, Cardiovascular Division, Deaconess Hospital, and Harvard Medical School, Boston (M.A.M., M.M., G.H.T., J.B.S., J.E.M.); the Department of Epidemiology, Harvard School of Public Health, Boston (M.A.M., M.M.); and the Department of Medicine, University of Massachusetts Medical School, Worcester (R.J.G.). Presented in part at the 64th Annual Scientific Sessions of the American Heart Association, Anaheim, Calif., November 11-14, 1991.The participants in the study are listed in the Appendix.
Address reprint requests to Dr. Mittleman at the Institute for Prevention of Cardiovascular Disease, Cardiovascular Division, Deaconess Hospital, 1 Autumn St., 5th Fl., Boston, MA 02215.
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