Mikhail A. Lebedev

 

Senior Research Scientist

Center for Neuroengineering

Department of Neurobiology

Duke University Medical Center

Box 3209

101 Research Drive

Durham, NC 27710

 

Telephone: (919) 668 1236

Fax: (919) 681 7055

 

E-mail: lebedev at neuro dot duke dot edu

 

RESEARCH

 

Representation of peripheral stimuli in the primary somatosensory cortex. In this study conducted at laboratory of Dr. Randall Nelson at the University of Tennessee, Memphis, I analyzed the representation of temporal patterns of peripheral somatosensory stimuli in the primary somatosensory cortex (S1) of awake, behaving monkeys.  Monkeys responded to vibrotactile stimulation of their palms with movements of their hands (wrist flexions and extensions).  It was found that many S1 neurons are entrained (or phase-locked) to peripheral vibration.  Moreover, entrainment patterns change during motor preparation, indicating premovement corollary discharges coming to S1 from motor areas of the brain.

 

References

Lebedev, M.A., Denton, J.M., Nelson, R.J. (1994) Vibration-entrained and premovement activity in monkey primary somatosensory cortex. J. Neurophysiol. 72: 1654-1673.

Lebedev, M.A., Nelson, R.J. (1996) High-frequency vibratory sensitive neurons in monkey primary somatosensory cortex: entrained and non-entrained responses to vibration during the performance of vibratory-cued hand movements. Exp. Brain Res. 111: 313-325.

 

Oscillatory patterns in cortical neurons. In this series of studies conducted with Dr. Randall J. Nelson I examined oscillatory patterns of activity in single neurons recorded in the cortex and basal ganglia of awake, behaving monkeys.  Oscillatory neurons exhibited specific modulations of their activity during the execution of motor tasks. Moreover, single-neuron oscillations were found to be directionally specific.

 

References

Lebedev, M.A., Wise, S.P. (2000) Oscillations in the premotor cortex: single-unit activity from awake, behaving monkeys.  Exp. Brain Res., 130: 195-215.

Lebedev, M.A., Nelson, R.J. (1999) Rhythmically firing neostriatal neurons in monkeys: activity patterns during reaction-time hand movements. J. Neurophysiol., 82: 1832-1842.

Lebedev, M.A., Nelson, R.J. (1995) Rhythmically firing (20-50 Hz) neurons in monkey primary somatosensory cortex: activity patterns during initiation of vibratory-cued hand movements. J. Comput. Neurosci. 2: 313-334.

 

Plasticity and information encoding in rat barrel cortex. In this study conducted at the laboratory of Dr. Mathew Diamond at SISSA, Trieste, Italy, multielectrode recordings in rat barrel cortex were used to uncover plasticity of sensory responses evoked by the changes in behavioral use of peripheral somatosensory inputs (whisker pairing). In addition, information-theoretic analysis of sensory representations in rat barrel cortex was performed.

 

References

Panzeri, S., Petersen, R.S., Schultz, S.R., Lebedev, M.A., Diamond, M.E. (2001) The role of spike timing in the coding of stimulus location in rat somatosensory cortex.  Neuron, 29: 769-777.

Panzeri, S., Peterrsen, R.S., Schultz, S.R., Lebedev, M.A., Diamond, M.E. (2001) Coding of stimulus location by spike timing in rat somatosensory cortex.  Neurocomputing, 44: 573-578.

Mitz, A.R., Boring, S.A., Wise, S.P., Lebedev, M.A. (2001) A novel food-delivery device for neurophysiological and neuropsychological studies in monkeys.  J. Neurosci. Methods, 109: 129-135.

Lebedev, M.A., Mirabella, G., Erchova, I., Diamond, M.E. (2000) Experience-dependent plasticity of rat barrel cortex: redistribution of activity across barrel-columns.  Cerebral Cortex, 10: 23-31.

 

Representation of multiple spatial variables in monkey frontal cortex. In this series of studies conducted at the laboratory of Steven Wise at NIMH, Bethesda, Maryland, I analyzed activity patterns of frontal cortex neurons that encode a variety of spatial parameters: orientation of selective spatial attention, target of reach, gaze angle, spatial memory. Behavioral tasks were specifically designed in such way that these variables were controlled independently.  A number of findings illuminating spatial encoding in the frontal cortex came from these studies.  For example, it was found that many premotor cortex neurons represent orientation of spatial attention rather than motor preparation.  In addition, it was shown that the majority prefrontal activity patterns commonly described as representing spatial working memory are related to the orientation of spatial attention.

 

References

Lebedev, M.A., Messinger, A., Kralik, J.D., Wise, S.P. (2004) Representation of attended versus remembered locations in prefrontal cortex. PLoS Biology, 2: 1919-1935.

Lebedev, M.A., Wise, S.P. (2002) Insights into seeing and grasping: distinguishing the neural correlates of perception and action. Behavioral and Cognitive Neuroscience Reviews, 1: 108-129.

Lebedev, M.A., Wise, S.P. (2001) Tuning for the orientation of spatial attention in dorsal premotor cortex.  Eur. J. Neurosci., 13: 1002-1008.

Lebedev, M.A., Douglass, D.K., Moody, S.L., Wise, S.P. (2001) Prefrontal cortex neurons reflecting reports of a visual illusion. J. Neurophysiol., 85: 1395-1411.

 

Brain-machine interfaces. My current work as a Senior Research Scientist at Miguel Nicolelis lab is a part of the effort of Duke University consortium to build prosthetic devices for restoration of motor control in neurologically disabled people. This ambitious goal can only be accomplished though collaboration of experts from many fields: biomedical engineers, clinicians, neurophysiologists. Being a member of this multidisciplinary team, I was involved in the development of a brain-machine interface for reaching and grasping, the study of representation of time by cortical neuronal ensembles, the studies of cortical representation of locomotion patterns in monkeys and rats, an investigation of predictions of EMG patterns from neuronal ensemble activity and a microstimulation study that explored the ways to sensorize neural prosthetic devices.

 

References

Lebedev, M.A., Nicolelis, M.A.L. (2005) Brain-machine interfaces: past, present and future. Trends in Neurosci., 29: 493-546..

Lebedev, M.A., Carmena, J.M., O’Doherty, J.E., Zacksenhouse, M., Henriquez, C.S., Principe, J.C., Nicolelis, M.A.L. (2005) Cortical ensemble adaptation to represent actuators controlled by a brain machine interface. J. Neurosci., 25: 4681-4693.

Santucci, D.M., Kralik, J.D., Lebedev , M.A., Nicolelis, M.A.L. (2005) Frontal and parietal cortical ensembles predict single-trial muscle activity during reaching movements Eur. J. Neurosci., 22: 1529-1540.

Kim, H.K., Biggs, S.J., Schloerb, D.W., Carmena, J.M., Lebedev, M.A., Nicolelis, M.A.L., Srinivasan, M.A. (2005). Continuous shared control stabilizes reach and grasping with brain-machine interfaces. IEEE Trans. on Biomed. Eng., in press.

Carmena, J.M., Lebedev, M.A., Henriquez, C.S., Nicolelis, M.A.L. (2005) Stable ensemble performance with single neuron variability during reaching movements in primates.  J. Neurosci., in press.

Sanchez, J.C., Carmena, J.M., Lebedev, M.A., Nicolelis, M.A., Harris, J.G., Principe, J.C. (2004) Ascertaining the importance of neurons to develop better brain machine interfaces. IEEE Trans Biomed Eng., 51: 943-953.

Carmena, J.M., Lebedev, M.A., Crist, R.E., O’Doherty, J.E., Santucci, D.M., Dimitrov, D.F., Patil, P.G., Henriquez, C.S., Nicolelis, M.A.L. (2003) Learning to control a brain-machine interface for reaching and grasping by primates.  PLoS Biology, 1: 193-208.

 

APPOINTMENTS

2002-present

Senior Research Scientist

Center for Neuroengineering, Department of Neuroscience, Duke University, NC

1997-2002

Research Fellow

Laboratory of Systems Neuroscience, National Institute of Mental Health, Bethesda, MD

1995-1997

Postdoctoral Fellow

Cognitive Neuroscience Sector, International School for Advanced Studies, Trieste, Italy

1995

Postdoctoral Fellow

Department of Anatomy and Neurobiology, University of Tennessee, Memphis, TN

1991-1995

Graduate Teaching Assistant

Department of Anatomy and Neurobiology, University of Tennessee, Memphis, TN

1986-1991

Research Fellow

Institute for the Problems of Information Transmission, Moscow, Russia

 

SOCIETY MEMBERSHIP

1992 - present

Society for Neuroscience

2005 - present

Cognitive Neuroscience Society

 

INVITED LECTURES

2007, June

Decoding and encoding with multielectrode implants

Neurizons. Max Planck Institute for Experimental Medicine, Göttingen, Germany

2007, April

Decoding multiple behavioral variables from neuronal ensemble activity

Advanced Telecommunications Research Institute International, Kyoto, Japan

2006, April

Encoding of attended versus remembered locations by prefrontal cortex neurons

Cognitive Neuroscience Meeting, San Francisco, California

2006, February

Obtaining accurate read-out of multiple behavioral variables from large neuronal ensembles

Barrow Neurological Institute, Phoenix, Arizona

2004, August

Frontal cortex mechanisms of spatial motor behavior

IBRO Summer School: Sensory and Integrative Neuroscience, Moscow, Russia

2003, December

Monkey attend, monkey do.  Dissociation of spatial attention from other variables in task-related activity of frontal cortex neurons

Department of Neurobiology and Anatomy, Wake Forest University, North Carolina

2002, May

Processing of spatial information in frontal cortex

Department of Neurobiology, Duke University, North Carolina

2002, April

Dissociation of spatial, mnemonic, attentional, and intentional signals related to reaching movements and eye movements in frontal cortex.

Neural Control of Movement Meeting, Naples, Florida

2002, February

Processing of spatial information in frontal cortex

Department of Psychology, Vanderbilt University, Nashville, TN

2000, July

Oscillations in the activity of individual premotor cortex neurons

Department of Psychology, Vanderbilt University, Nashville, TN

1998, December

Premotor cortex: detection of oscillations in single-unit activity

Human Motor Control Section, National Institute of Neurological Disorders and Stroke

1998, May

Single unit oscillations in SI during reaction-time movements

Second Borsellino College of Neurophysics.  The Abdus Salam International Centre for Theoretical Physics

1995, February

Rhythmic activity of SI neurons

Cognitive Neuroscience Sector, International School for Advanced Studies, Trieste, Italy

 

INVITED REVIEWER

Journal of Neurophysiology

European Journal of Neuroscience

Experimental Brain Research

Neural Computation

IEEE Transactions on Biomedical Engineering

International Journal of Psychophysiology

 

PUBLICATIONS

  1. Zacksenhouse, M., Lebedev, M.A., Carmena, J.M., O’Doherty, J.E., Henriquez, C.S., Nicolelis, M.A.L. Cortical Modulations Increase in Early Sessions with Brain-Machine Interface. PlosOne (in press).
  2. Fitzsimmons, N.A., Drake, W., Hanson, T.L., Lebedev, M.A., Nicolelis, M.A.L. (2007) Primate Reaching Cued by Multichannel Spatiotemporal Cortical Microstimulation. J. Neurosci., 27: 5593-5602.
  3. Lebedev, M.A., Nicolelis, M.A.L. (2006) Brain-machine interfaces: past, present and future. Trends in Neurosci., 29: 493-546.
  4. Kim, S..P, Sanchez, J.C., Rao, Y.N., Erdogmus, D., Carmena, J.M., Lebedev, M.A., Nicolelis, M.A.L., Principe, J.,C. (2006) A comparison of optimal MIMO linear and nonlinear models for brain-machine interfaces. J Neural Eng., 3: 145-161.
  5. Kim, H.K., Biggs, S.J., Schloerb, D.W., Carmena, J.M., Lebedev, M.A., Nicolelis, M.A.L., Srinivasan, M.A. (2006). Continuous shared control stabilizes reach and grasping with brain-machine interfaces. IEEE Trans. on Biomed. Eng., 53(6): 1164-1173.
  6. Lebedev, M.A., Carmena, J.M., O’Doherty, J.E., Zacksenhouse, M., Henriquez, C.S., Principe, J.C., Nicolelis, M.A.L. (2005) Cortical ensemble adaptation to represent actuators controlled by a brain machine interface. J. Neurosci., 25: 4681-4693.
  7. Santucci, D.M., Kralik, J.D., Lebedev , M.A., Nicolelis, M.A.L. (2005) Frontal and parietal cortical ensembles predict single-trial muscle activity during reaching movements Eur. J. Neurosci., 22: 1529-1540.
  8. Carmena, J.M., Lebedev, M.A., Henriquez, C.S., Nicolelis, M.A.L. (2005) Stable ensemble performance with single neuron variability during reaching movements in primates.  J. Neurosci., in press.
  9. Lebedev, M.A., Messinger, A., Kralik, J.D., Wise, S.P. (2004) Representation of attended versus remembered locations in prefrontal cortex. PLoS Biology, 2: 1919-1935.
  10. Sanchez, J.C., Carmena, J.M., Lebedev, M.A., Nicolelis, M.A., Harris, J.G., Principe, J.C. (2004) Ascertaining the importance of neurons to develop better brain machine interfaces. IEEE Trans Biomed Eng., 51: 943-953.
  11. Carmena, J.M., Lebedev, M.A., Crist, R.E., O’Doherty, J.E., Santucci, D.M., Dimitrov, D.F., Patil, P.G., Henriquez, C.S., Nicolelis, M.A.L. (2003) Learning to control a brain-machine interface for reaching and grasping by primates.  PLoS Biology, 1: 193-208.
  12. Lebedev, M.A., Wise, S.P. (2002) Insights into seeing and grasping: distinguishing the neural correlates of perception and action. Behavioral and Cognitive Neuroscience Reviews, 1: 108-129.
  13. Erchova, I., Lebedev, M.A., Diamond, M.E. (2002) Somatosensory cortical neuronal population activity across states of anesthesia. Eur. J. Neurosci., 15: 744-752.
  14. Lebedev, M.A., Wise, S.P. (2001) Tuning for the orientation of spatial attention in dorsal premotor cortex.  Eur. J. Neurosci., 13: 1002-1008.
  15. Lebedev, M.A., Douglass, D.K., Moody, S.L., Wise, S.P. (2001) Prefrontal cortex neurons reflecting reports of a visual illusion. J. Neurophysiol., 85: 1395-1411.
  16. Nelson, R.J., Lebedev, M.A. (2001) Deciphering the code - dynamic modulation of neural activity during tactile behavior - chapter 10.  In: Nelson R.J. (Ed.) Somatosensory System: Deciphering the Brain's Own Body Image, CRC Press.
  17. Panzeri, S., Petersen, R.S., Schultz, S.R., Lebedev, M.A., Diamond, M.E. (2001) The role of spike timing in the coding of stimulus location in rat somatosensory cortex.  Neuron, 29: 769-777.
  18. Panzeri, S., Peterrsen, R.S., Schultz, S.R., Lebedev, M.A., Diamond, M.E. (2001) Coding of stimulus location by spike timing in rat somatosensory cortex.  Neurocomputing, 44: 573-578.
  19. Mitz, A.R., Boring, S.A., Wise, S.P., Lebedev, M.A. (2001) A novel food-delivery device for neurophysiological and neuropsychological studies in monkeys.  J. Neurosci. Methods, 109: 129-135.
  20. Lebedev, M.A., Mirabella, G., Erchova, I., Diamond, M.E. (2000) Experience-dependent plasticity of rat barrel cortex: redistribution of activity across barrel-columns.  Cerebral Cortex, 10: 23-31.
  21. Lebedev, M.A., Wise, S.P. (2000) Oscillations in the premotor cortex: single-unit activity from awake, behaving monkeys.  Exp. Brain Res., 130: 195-215.
  22. Lebedev, M.A., Nelson, R.J. (1999) Rhythmically firing neostriatal neurons in monkeys: activity patterns during reaction-time hand movements. J. Neurophysiol., 82: 1832-1842.
  23. Mirabella, G., Lebedev, M.A., Diamond, M.E. (1999) Integration and storage of sensory events in adult rat barrel cortex. In: M. Kossut (Ed.) Plasticity of Adult Rat Barrel Cortex, F.P. Graham, Johnson City, TN: 97-126.
  24. Lebedev, M.A., Nelson, R.J. (1996) High-frequency vibratory sensitive neurons in monkey primary somatosensory cortex: entrained and non-entrained responses to vibration during the performance of vibratory-cued hand movements. Exp. Brain Res. 111: 313-325.
  25. Lebedev, M.A., Nelson, R.J. (1995) Rhythmically firing (20-50 Hz) neurons in monkey primary somatosensory cortex: activity patterns during initiation of vibratory-cued hand movements. J. Comput. Neurosci. 2: 313-334.
  26. Lebedev, M.A., Denton, J.M., Nelson, R.J. (1994) Vibration-entrained and premovement activity in monkey primary somatosensory cortex. J. Neurophysiol. 72: 1654-1673.
  27. Lebedev, M.A. (1993) Further observations on ischemic suppression of motor units in human soleus muscle. A single case study. J. Electromyography and Kinesiology 3: 183-186.
  28. Gurfinkel, V.S., Lebedev, M.A., Levick, Yu.S. (1992) What about the so-called neck reflexes in humans? In: A. Bertoz, W. Graf, P. P. Vidal (Eds) The Head-Neck Sensory Motor System, New York, Oxford, Oxford University Press: 543-547.
  29. Gurfinkel, V.S., Lebedev, M.A., Levik, Yu.S. (1992) Effects of reversal in the human equilibrium regulation system. Neirofiziologiya (Kiev) 24: 462-470.  Translation into English: Neurophysiology 24: 297-304.
  30. Gurfinkel, V.S., Lebedev, M.A., Levik, Yu.S. (1992) The sensory effects caused by neck afferentation. Sensory Systems 6: 83-87.
  31. Lebedev, M.A., Polyakov, A.V. (1992) Analysis of surface EMG of human soleus muscle subjected to vibration. J. Electromyography and Kinesiology 2: 26-35.
  32. Gurfinkel, V.S., Levick, Yu.S. Lebedev, M.A. (1991) Body scheme concept and motor control. Body scheme in the postural automatisms regulation. In: Intellectual Processes and Their Modelling, Moscow, Nauka: 24-53.
  33. Lebedev, M.A. (1991) Impairment of human soleus motor units during ischemia. J. Electromyography and Kinesiology 1: 244-249.
  34. Lebedev, M.A., Polyakov, A.V. (1991) Analysis of the interference electromyogram of the human soleus muscle under vibrational stimulation. Neirofiziologiya (Kiev) 23: 57-65. Translation into English: Neurophysiology 23: 47-54.
  35. Lebedev, M.A., Polyakov, A.V. (1990) The analysis of surface EMG of human soleus muscle during vibration. In: Systems of Information Transmission and Processing. Institute for the Problems of Information Transmission, USSR Acad. Sci, Moscow: 34-38.
  36. Gurfinkel, V.S., Levik, Yu.S., Lebedev, M.A. (1989) Immediate and remote postactivation effects in the human motor system. Neirofiziologiya (Kiev) 21: 343-351. Translation into English: Neurophysiology 21: 247-253.
  37. Gurfinkel, V.S., Levik, Yu.S., Lebedev, M.A. (1989) The postural automatism revealed by the enhancement of tonic background. Postural automatisms revealed by tonic background activation. Doklady Akademii Nauk SSSR 305:1266-1269.
  38. Lebedev M.A., Polyakov A.V. (1989) Switched vibratory activation of muscle. 1. Spectral analysis of surface EMG. In: Systems of Information Transmission and Processing. Institute for the Problems of Information Transmission USSR Acad. Sci, Moscow: 54-58.
  39. Polyakov, A.V., Lebedev, M.A. (1989) Switched vibratory activation of muscle.  2. Motor unit firing. In: Systems of Information Transmission and Processing.  Institute for the Problems of Information Transmission, USSR Acad. Sci, Moscow: 59-61.
  40. Lebedev, M.A. (1988) Domination of peripheral visual field in human vertical posture control. In: Systems of Information Transmission and Processing. Part 1. Institute for the Problems of Information Transmission, USSR Acad. Sci, Moscow: 61-63.
  41. Lebedev, M.A. (1988) Research methods of basic postural control mechanisms.  In: Systems of Information Transmission and Processing. Part 2. Institute for the Problems of Information Transmission, USSR Acad. Sci, Moscow: 64-67.
1