Pyridoxamine
From Wikipedia, the free encyclopedia
| Pyridoxamine | |
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4-(aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol
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| Identifiers | |
| CAS number | 85-87-0  |
| PubChem | 1052 |
| ChemSpider | 1023 |
| SMILES |
Oc1c(CN)c(cnc1C)CO
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| Properties | |
| Molecular formula | C8H12N2O2 |
| Molar mass | 168.19 g mol−1 |
| (what is this?) (verify) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
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| Infobox references | |
Pyridoxamine is one of the compounds composing vitamin B6, along with pyridoxal and pyridoxine. Pyridoxamine is converted to the biologically active form, pyridoxal 5-phosphate, and inhibits formation of advanced glycation endproducts.
Pyridoxamine is based on a pyridine ring, with hydroxyl, methyl, aminomethyl, and hydroxymethyl substituents. It differs from pyridoxine by the subsitituent at the 4-position.
Pyridoxamine is used as a dietary supplement, often as the hydrochloride salt, pyridoxamine dihydrochloride. However, in the United States, the FDA ruled in January 2009 that pyridoxamine must be regulated as a pharmaceutical drug because it is the active ingredient in Pyridorin, a drug designed to prevent the progression of diabetic nephropathy.[1] As a consequence, pyridoxamine can no longer be marketed in the United States as a dietary supplement.
[edit] References
- ^ FDA finds vitamin B6 form not legal in supplements at newsfood.com
