MEF to Functional Neurons with Asc11, Brn2, and Myt11
Verbuchen, Ostermeier et al., Nature
Researchers identify three factors that, when expressed in combination, rapidly and efficiently convert mouse embryonic and postnatal fibroblasts into functional neurons in vitro. Asc11, Brn2, and Myt11 have shown to induce neuronal cells that express multiple neuron-specific proteins and form functional synapses. The authors write that their finding could have implications for studies of neural development and disease modeling as well as regenerative medicine.
BGI to Sequence Tiger, Lion, and Leopard Species This Year
The project, announced just before the start of the Chinese year of the tiger last weekend, is part of BGI's goal to sequence the genomes of 1,000 plant and animal reference species over the next two years.