The new six-part show, described by Channel 4 as "no holds barred", will air on Friday nights at 11pm with regular standups including Rich Hall, Jack Whitehall, Andi Osho and Kevin Bridges.
Channel 4 has returned to the format, which has its roots in The 11 O'Clock Show which helped propel the careers of Sacha Baron Cohen and Ricky Gervais, following the surprise success of the broadcaster's comedy-themed alternative election night coverage in May.
The new series, which is being filmed at Koko in Camden, will look at the week's politics, sport and celebrity news with the first show to air on 25 June.
Channel 4 promises it will be a "late night, edgy and on the knuckle satirical take on the big stories and big themes of the week" and be "outrageously alternative".
Production company Open Mike is behind Live At The Apollo and Michael McIntrye's Comedy Roadshow.
Whitehall and Osho have previously featured in Tonightly while Hall appeared in Channel 4's alternative election night coverage.
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