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Ann Thorac Surg 1996;61:1727-1733
© 1996 The Society of Thoracic Surgeons


Original Article: Cardiovascular

Heart Transplantation for Chronic Chagas' Heart Disease

Edimar A. Bocchi, MD, Giovanni Bellotti, MD, Amilcar O. Mocelin, MD, David Uip, MD, Fernando Bacal, MD, Maria L. Higuchi, MD, Vicente Amato-Neto, MD, Alfredo Fiorelli, MD, Noedir A. G. Stolf, MD, Adib D. Jatene, MD, Fulvio Pileggi, MD

Heart Institute, São Paulo University Medical School, São Paulo, Brazil

Accepted for publication February 6, 1996.

Background. Chagas' disease has been considered a contraindication to heart transplantation as Trypanosoma cruzi infection could recur after immunosuppression.

Methods. We report the follow-up of 22 patients who underwent orthotopic heart transplantation for treatment of end-stage chronic Chagas' heart disease, divided in two groups. Group 1 consisted of 9 patients operated on from September 1985 to June 1991, and group 2 patients underwent transplantation from July 1991 Aug 91 in text to June 1995. After our early experience with group 1, we attempted to use a lower cyclosporine dosage in group 2.

Results. Total actuarial survival at 24 months was 60%, and it was better for group 2 (33% for group 1, 80% for group 2, p = 0.008). Parasitemia occurred similarly in both groups, but Chagas' disease reactivation was seen in 5 group 1 patients and in 1 group 2 member (p < 0.002). Neoplasia developed in 5 group 1 patients and 1 group 2 patient, and contributed to death in 3 of them.

Conclusions. These data demonstrate satisfactory outcome of cardiac transplantation in patients with end-stage Chagas` heart disease in the second phase of our experience. Further progress is necessary to improve the results and evaluate its proper role in the management of this disease.




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