Two first half goals from the hosts secured a 2-0 win for Huddersfield over Saints at the Galpharm Stadium.
An opening five minute barrage from the Terriers forced an early lead for Lee Clark's side as Anthony Pilkington became the third Town player to put in an effort on goal during a lightning opening spell from the home side. The midfielder slammed his shot in from eight yards out, and from there Huddersfield rarely looked back.
The first 45 minutes remained a competitive affair, but the killer second goal which arrived at the end of the half extinguished Saints' hopes of taking anything back to the south coast.
Nigel Adkins' side started the second half strongly, and were unfortunate not to get back into it as a series of stoppages, most notably a lengthy one for one of the referee's assistants who went off with blurred vision halted any momentum that the visitors tried to build as they left West Yorkshire defeated.
Huddersfield: Bennett, Peltier (Arfield 51), Gudjonsson, P. Clarke, Kay, Pilkington (Garner 59), Johnson, Ridehalgh, Carey, Novak, Lee (Rhodes 78). Subs (not used): Colgan, N. Clarke, McCombe, Atkinson.
Saints: Davis, Butterfield, Fonte, Seaborne, Harding, Puncheon (Schneiderlin 75), Hammond, Chaplow, Lallana, Guly (Barnard 67), Lambert (Bignall 70). Subs (not used): Bialkowski, Richardson, Jaidi, Chamberlain.
Referee: Mr. C. Webster (Tyne & Wear)
Attendance: 14, 792
Adkins stuck with the same team that beat Tranmere Rovers last time out.
Morgan Schneiderlin returned from international duty and took his place amongst the substitutes where he was joined by Frazer Richardson, who featured in a Saints squad for the first time.
Saints got the match under way in their black away strip defending the end housing the travelling support on an overcast afternoon.
It was the hosts who made the brighter start and Lee Clark' Terriers took the lead after peppering Kelvin Davis' goal inside the first five minutes. First up was a free-kick from the edge of the area which the 'keeper brilliantly palmed away, but from the resulting corner, Town made the breakthrough.
Joey Gudjonsson smashed a rising shot from the left which clattered the far post, and on the follow up midfielder Anthony PILKINGTON lashed home into the far right corner giving Davis absolutely no chance to make it 1-0.
Saints responded with José Fonte's low tenth minute strike which Town shot stopper Ian Bennett managed to push away to safety, but almost immediately afterwards Huddersfield ought to have extended their lead when striker Alan Lee found himself through on goal. Faced one on one with Davis, the Irishman tried to lob Saints' club captain from some distance, but fortunately his ambitious effort comfortably cleared the bar.
The visitors started to find their rhythm with some purposeful passing moves, but were unable to unlock a resolute looking Town defence inside the opening 20 minutes of action.
Davis was tested again when Graham Carey struck a low shot following a corner from the hosts, and the same man fired wide from distance as the half hour mark approached.
Defender Anthony Kay was the next to force Davis into a smart save as the Terriers made the most of another set piece, but Saints remained unruffled.
Adam Lallana and Jason Puncheon continued to switch flanks to good effect, and a jinking run from the former produced the visitors' best chance of an equaliser as Lallana's cross picked out Lambert who saw his header cleared off line by Damien Johnson, before Puncheon struck over from the rebound.
A booking for either side followed in separate incidents, as first, Town's goal scorer Pilkington received a caution for a late foul on Davis. That preceded Saints skipper Dean Hammond collecting his fifth yellow card of the campaign for a similar tackle inside his own half five minutes before the break.
Huddersfield captain Peter Clarke came close to doubling his side's advantage after arriving late to connect to a cross to the far post, but his effort squirmed wide of Davis' right post.
Seaborne joined Hammond in the book in the last minute of the half, but worse was to come as the resulting free-kick was cleared into the path of Joey GUDJONSSON who rifled home a fierce shot from the edge of the box into the far corner to make it 2-0.
Half Time: Huddersfield 2-0 Saints
With a flea in their ear from the interval, Saints burst forward inside the opening minute of the re-start with Puncheon forcing the ball across to Guly in the area, but the Brazilian saw his low goalbound shot blocked by a couple of blue and white shirts.
Huddersfield made their first change on 51 minutes which saw Lee Peltier replaced by Scottish midfielder Scott Arfield in a bid to open the game out even further.
Seaborne denied Lee Novak from bending a shot in at goal, but Saints continued to create at the other end with Lambert seeing a header saved at the near post by Bennett.
In going for the header Lambert clashed heads with Peter Clarke which required the forward to briefly leave the field of play and return with a bandage wrapped around his forehead.
During that time the hosts replaced Pilkington with Joe Garner as the game reached the hour mark.
In the 65th minute Danny Butterfield became the third Saint to receive a booking as he fouled Gudjonsson around 25 yards out from goal, but the resulting free-kick was charged down by Chaplow.
Saints swapped Guly for Lee Barnard in attack, and followed it up with Nicholas Bignall's introduction in place of Lambert as the visitors refreshed their forward line.
A switch too was made on the sidelines as one of the referee's assistants was unable to continue, leading to an introduction for Mr Tyas on the near touchline.
After a lengthy wait for the assistants to get themselves in order Saints made their third change with Morgan Schneiderlin coming on for Puncheon with around quarter of an hour still to play.
Bignall earned his new side a corner with his first touch in Saints colours, but the stoppages continued as Town made their final switch with Alan Lee replaced by Jordan Rhodes in the Terriers' attack.
The visitors forced a succession of corners but Town continued to frustrate Saints, as thy tried to get themselves back into the game.
The longer than anticipated stoppage for the injury to a match assistant gave a false look to the stopwatch as eleven minutes of additional time went up from the stand-in fourth official.
Bignall remained lively as he made an impact on his Saints bow, but the visitors were further disappointed when Fonte also went into the book late on for a foul on Gudjonsson.
The last of the action saw Bignall cushion a headed opportunity for Chaplow from close range, but the midfielder's effort couldn't find the target on a day when nothing clicked for Saints in attack.
Full Time: Huddersfield 2-0 Saints