Gerhard Rödel - Mitochondrial biogenesis
Previous and current research
Mitochondria are essential organelles of eukaryotic cells. They are involved in a number of anabolic and catabolic
pathways and play a key role in cellular energy metabolism by oxidative generation of ATP. Biogenesis of mitochondria
involves a complex interplay between the genetic systems of the organelle and the nucleus. The few, mostly hydrophobic
proteins that are encoded by mitochondrial DNA and translated on mitochondrial ribosomes, constitute subunits of the
oxidative phosphorylation system (OXPHOS). The proteins encoded in the nuclear DNA are translated on cytosolic ribosomes
and imported into mitochondria. These proteins include structural proteins, enzymes or enzyme subunits, components of
the import-, replication-, transcription- and translation-machinery and chaperones. Many basic studies on mitochondrial
biogenesis employ yeast cells, because mutants with affected OXPHOS biogenesis can easily be isolated due to their
inability to grow on non-fermentable carbon sources like glycerol.
Future prospects and goalsFuture prospects aim at the detailed characterization of (i) the mitochondrial phosphoproteome, (ii) the mitochondrial copper metabolism in yeasts (S. cerevisiae and S. pombe) and human cell lines, and (iii) the impact of mitochondrial dysfunction on SC differentiation.
Selected publicationsOswald C, Krause-Buchholz U, Rödel G. (2009): Knockdown of human COX17 affects assembly and supramolecular organization of cytochrome c oxidase. J Mol Biology 389:470-479.
Mkandawire M, Pohl A, Gubarevich T, Lapina V, Appelhans D, Rödel G, Pompe W, Schreiber J, Opitz J (2009): Selective targeting of green fluorescent nanodiamond conjugates to mitochondria in HeLa cells. J Biophotonics 2(10):596-606.
Tauche A, Krause-Buchholz U, Rödel G. (2008) : Ubiquinone biosynthesis in Saccharomyces cerevisiae: Molecular organization of O-methylase Coq3p depends on Abc1p/Coq8p. FEMS Yeast Res. 8(8):1263-1275.
Gey U, Czupalla C, Hoflack B, Rödel G, Krause-Buchholz U (2008) : Yeast pyruvate dehydrogenase complex is regulated by a concerted activity of two kinases and two phosphatases. J Biol Chem. 283(15):9759-9767.
Khalimonchuk O, Rödel G (2005 ): Biogenesis of cytochrome c oxidase (Review). Mitochondrion 5:363-388.
1981: Dr. rer. nat. University of Munich
1981-1987: Group leader at the University of Munich
1987: Professor for Molecular Biology and Pathology, University of Ulm
1987-1994: Head of the Laboratory of Molecular Biology and Pathology, University of Ulm
1994: Professor for Genetics and Director of the Institute of Genetics, Dresden, University of Technology
2006: Speaker, Dresden International Graduate School for Biomedicine and Bioengineering (DIGS-BB)