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From Asheville, NC (approximately 1 hour)
Take I-40 west to exit 27 (Great Smoky Mountains Expressway). Continue west on U.S. 74 past Waynesville, Sylva, and Dillsboro to exit 74, Cherokee. U.S.Hwy 441 will take you into Cherokee.

From Knoxville, TN (approximately 2 hours)
Take I-40 east into North Carolina to exit 27 (Great Smoky Mountains Expressway). Continue west on U.S. 74 beyond Waynesville, Sylva, and Dillsboro to exit 74, Cherokee. U.S. Hwy 441 will take you into Cherokee.

From Atlanta, GA (approximately 2.5 hours)
Take I-85 north to I-985 which becomes U.S. 23 north, and eventually becomes U.S. 23/441 north. You will travel through the towns of Clayton, GA, Franklin, NC, and Dillsboro, NC. Just beyond Dillsboro, take U.S. 74 (Great Smoky Mountains Expressway) west to exit 74, Cherokee. U.S.Hwy 441 will take you into Cherokee.

Nearest Airports:
Asheville Regional Airport (AVL), Asheville, NC
McGhee Tyson Airport (TYS), Knoxville, TN

Other information:
Gatlinburg is located just 38 miles from Cherokee and a wonderfully scenic drive via the Great Smoky Mountains National Park via highway 441 South.