'When we get together, bad things happen!': Wolf Pack terrorised in Tijuana by crime boss John Goodman in new Hangover Part III trailer

By Tess Eyrich

PUBLISHED: 18:02 EST, 11 April 2013 | UPDATED: 09:14 EST, 12 April 2013

They've tackled Las Vegas and Thailand, and now the Hangover boys are headed to Mexico.

A newly released trailer for the third installment of the franchise finds the gang in Tijuana after being pitted against a ruthless crime boss played by John Goodman.

Zach Galifianakis, Bradley Cooper, Ed Helms, Justin Bartha and Ken Jeong will reprise their original roles in the upcoming film, directed by Todd Phillips.

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Busted: The newest Hangover 3 trailer, released Thursday, pits the wolf pack against a vengeful crime boss played by John Goodman

Ambushed: Alan (Galifianakis) tries to evade one of crime boss Goodman's cronies

The saga promises to begin just as its two predecessors did: with a road trip.

Hijinks ensue when the guys attempt to bring Alan (Galifianakis) to a rehab facility in the wake of his father's death.

A crime boss (Goodman) thwarts the quartet in the midst of its journey, kidnapping Doug (Bartha) and threatening bodily harm unless the remaining men find Leslie Chow (Jeong), who's stolen $21 million from the thug. 

The Hangover Part III new trailer

Thwarted: The guys' attempt to bring Alan (Galifianakis) to rehab is stymied when they are ambushed by a thug (Goodman) who takes Doug (Bartha) hostage

Back for more: Ken Jeong returns to the franchise as Chinese gangster Leslie Chow

Revenge: Crime boss Goodman is hunting Leslie Chow (Jeong), who recently stole $21 million from him

The guys trek to Mexico in search of Chow, who has fled to Tijuana after a stint in prison.

Chow, now involved in a cockfighting operation, dons a sombrero to walk the crowded streets with the trio.

After recovering Chow, the gang treads familiar territory in Las Vegas, where Phil (Cooper) can be seen scaling the side of Caesars Palace using a twisted bed sheet. 

Southbound: The guys descend upon Mexico, where Chow (Jeong) has fled to Tijuana after a stint in prison

Wild nights: The gang prowls the streets of Tijuana

Fully loaded: Things turn violent when Chow (Jeong) brandishes a pistol

Later, Melissa McCarthy appears in a cameo role sporting a violet-tinged mullet.  

The Hangover Part III will arrive in theaters on May 24.

The first two installments of the franchise, released in 2009 and 2011, grossed a combined $1 billion.

Hanging by a thread: Phil (Cooper) can be seen scaling the side of Caesars Palace using only a bed sheet

Smile for the camera: Alan (Galifianakis) is eager to document Phil's (Cooper) rapelling skills

Old stomping grounds: The men tread familiar territory in Las Vegas

Usual suspect: Chow (Jeong) accompanies the guys on their return to Sin City