Marbofloxacin
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| Systematic (IUPAC) name | |
| 9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyridol(3,2,1-ij)(4,2,1)benzoxadiazin-6 carboxylic acid | |
| Clinical data | |
| AHFS/Drugs.com | International Drug Names |
| Pregnancy cat. | ? |
| Legal status | veterinary prescription only |
| Routes | oral |
| Identifiers | |
| CAS number | 115550-35-1  |
| ATCvet code | QJ01MA93 |
| ChemSpider | 54663  |
| UNII | 8X09WU898T |
| ChEMBL | CHEMBL478120 |
| Chemical data | |
| Formula | C17H19FN4O4 |
| Mol. mass | 362.356 |
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Marbofloxacin is a potent antibiotic of the 3rd generation fluoroquinolone group. It is used in veterinary medicine under the trade names Marbocyl and Zeniquin. A formulation of marbofloxacin combined with clotrimazole and dexamethasone is available under the name Aurizon (CAS number 115550-35-1).
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Mechanism of action [edit]
Marbofloxacin is a quinolone, and acts by inhibiting bacterial DNA replication. It is effective against enterobacteria, Pasteurella, Pseudomonas and staphylococci.[1]
Application [edit]
Marbofloxacin can be used both orally and topically. It is particularly used for infections of the skin, respiratory system and mammary glands, as well as with urinary tract infections in dogs and cats. For dogs, a dose of approximately 2 mg/kg is used. The duration of treatment is usually at least five days, longer if there is a concurrent fungal or yeast infection.[2]
Contraindications and side effects [edit]
Marbofloxacin should usually be avoided in young animals, during pregnancy where central nervous system accumulation can occur, or when there is an existing kidney problem. Under certain conditions it can cause discomfort such as cramps, treatable with Valium. Other side effects are vomiting and anorexia.
See also [edit]
References [edit]
- ^ Le Carrou J, Laurentie M, Kobisch M, Gautier-Bouchardon AV (June 2006). "Persistence of Mycoplasma hyopneumoniae in experimentally infected pigs after marbofloxacin treatment and detection of mutations in the parC gene". Antimicrob. Agents Chemother. 50 (6): 1959–66. doi:10.1128/AAC.01527-05. PMC 1479153. PMID 16723552.
- ^ Rougier S, Borell D, Pheulpin S, Woehrlé F, Boisramé B (October 2005). "A comparative study of two antimicrobial/anti-inflammatory formulations in the treatment of canine otitis externa". Vet. Dermatol. 16 (5): 299–307. doi:10.1111/j.1365-3164.2005.00465.x. PMID 16238809.
External links [edit]
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