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Don't you look great! Drew Barrymore grins as she warmly hugs co-star Toni Collette at premiere of their film Miss You Already

Published: 18:23 EST, 12 September 2015 | Updated: 18:56 EST, 12 September 2015

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They play the best of friends, living life through thick and thin in their latest film.

And Miss You Already co-stars Drew Barrymore and Toni Collette could not wait to reunite off the set, as the pair demonstrated at the premiere of their film at the Toronto International Film Festival on Saturday.

The 40-year-old actress beamed in delight when she approached Toni, 42, before pulling her in for a warm and tight embrace.

Don't you look great! Drew Barrymore was grinning when she approached her co-star Toni Collette at the premiere of their film Miss You Already at the Toronto International Film Festival on Saturday

BFFs: Barrymore and Toni exchanged a warm and tight embrace

Drew and Toni looked equally fantastic in their mismatching garments.

True to her free-spirited form, Drew donned an exotic blue floral dress that had a cut-out along her low back and skimmed the red carpet with a modest, sheer train.

Her sandy blonde locks tumbled down in its usual wild and beachy hairdo, and her youthful complexion glowed with a rosy hue of blush and a flattering slick of jet black eyeliner.

Polar opposites! Barrymore caught the eye in an exotic floral blue dress, while Collette looked on the bright side with her mustard yellow skirt

Free-spirited: The 40-year-old walked an elegant line in her semi-sheer number

Toni was Drew's polar opposite with her chic mustard yellow skirt that draped on the floor and flattered her slender waistline.

The sun-kissed Australian actress swept her cropped pixie haircut across her forehead in a slightly edgy 'do, and she highlighted her healthy tan with bronze eye shadow and a matching shade of blush.

Large and ornate silver earrings glammed up her complexion, and she carried a marble inspired clutch.

Sunny side up! The sun-kissed In Her Shoes star was a sight to behold as she arrived to the event, waving to fans

Star treatment! An assistant hovered close by the star, carrying a large black umbrella for her

Once Drew and Toni joined Miss You Already director Catherine Hardwicke, the two stars erupted into laughter.

The co-stars fiercely squeezed each other once again, and Catherine stood beside the pair, smiling and appearing to clap.

In Miss You Already, Drew and Toni portray childhood friends, who remain attached at the hip even in their adult years.

Three's company! The co-stars howled in laughter beside Miss You Already director Catherine Hardwick

Just one more! The pair fiercly embraced, while their director grinned and appeared to be clapping nearby

However, Toni's free-spirited character Milly is abruptly faced with a cancer diagnosis, while Drew's character Jess finally finds herself pregnant after various attempts.

During an interview with Entertainment Tonight Canada at the premiere, Drew revealed she identified with the role of Milly.

'I was channelling all my friends who are much more of like, the mature rocks in my life, and I feel like I've always been almost more like Toni's character, just more, I don't know, tornado-ish,' Drew told the website.

'I really channelled the people that I've always looked up to and wanted to become like. And hopefully I am more like that person in my life now and so I pretended to be that person in this film,' she added.

Miss You Already will hit U.S. cinemas on November 6.

'Tornado-ish': Is the word the mother-of-two used when she revealed she identified with Toni's character Milly during an interview with Entertainment Tonight Canada