Can Mourinho end the Lyon jinx? Real Madrid boss Jose sets his sights on Champions League victory

Not them again: Jean II Makoun celebrates after scoring for Lyon against Real Madrid last season

Not them again: Jean II Makoun celebrates after scoring for Lyon against Real Madrid last season

Jose Mourinho will try to do what no other Real Madrid coach has managed by beating Lyon in the Champions League on Tuesday night.

Although Mourinho's ambition is to win the Champions League as coach of three different clubs, his immediate task is beating Lyon.

The seven-time French champions have proven to be a thorn in Madrid's side recently. Lyon is unbeaten in six matches against Madrid - winning all three of the home games - and eliminated the Spanish club from the last 16 last year.

'I am not losing sleep over Lyon or any other team,' Mourinho said after Madrid's 2-0 win over Levante on Saturday. 'Ever since we drew Lyon, we have been studying and learning about them.'

Mourinho knows he is under immense pressure to restore Madrid's European pedigree - a task he is not taking lightly despite the gulf between the sides. Lyon reached the semi-finals for the first time last season, while Madrid has won the competition a record nine times.

'It's been years since Madrid made it (to the quarter-finals), and it's because they have never beaten Lyon,' he said.

Last season, Lyon's late equalizer in Madrid eliminated the Spanish club, then coached by Manuel Pellegrini.

Lyon beat Madrid at home and drew away in the 2005-06 group stages and did so again the following season when Madrid was coached by Fabio Capello.

Mourinho won the Champions League for the first time with Porto in 2004, and again with Inter Milan last year. But the odds are against him matching the treble he achieved with Inter last season. Madrid are five points behind Barcelona in the title race and also play the league leaders in the Copa del Rey final in April.

For Lyon coach Claude Puel, even one trophy would be nice. Now in his third season, Puel has yet to win anything. He regularly feels the wrath of the club's fans and has twice needed the public backing of president Jean-Michel Aulas.

Puel has taken Lyon further in Europe than any other coach, but is likely to be replaced if he fails to win a trophy.

Lyon has scored eight goals in the last two games to move within four points of French leader Lille.

'We're coming into form at the right time,' Lyon defender Cris said.

The Real deal: Jose Mourinho in training ahead of the Champions League clash with Lyon

The Real deal: Jose Mourinho in training ahead of the Champions League clash with Lyon

Lyon had some bad luck when Argentina forward Lisandro Lopez injured his hamstring in training on Thursday, ruling him out of Tuesday's match. Puel quashed reports that Lopez injured himself kicking a ball in anger after learning he was rested for Friday's 4-0 win over Nancy.

'You have to respect the player,' Puel said. 'He is injured and it's a handicap for us.'

Puel will likely put Cesar Delgado wide left and play Bafetimbi Gomis in the lone striker's role with France playmaker Yoann Gourcuff just behind him. Gourcuff scored with a volley against Nancy, but is still short of his best form.

Madrid, meanwhile, is close to full strength. Mourinho rested midfielders Xabi Alonso and Mesut Oezil along with defender Pepe against Levante, and brought on striker Emmanuel Adebayor as a late substitute.

Mourinho must choose between Adebayor or former Lyon forward Karim Benzema as his main striker, with top scorer Cristiano Ronaldo and Argentina winger Angel Di Maria on either flank.

Benzema hopes his goal against Levante, and his excellent recent performance against Brazil where he scored France's winning goal, will be enough to persuade Mourinho.

'If I'm lucky enough to play I will do everything I can,' Benzema said. 'This match will be different to last year. Our team has changed... I think we are going to defeat Lyon and win the Champions League.'